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Source: Experimental Cell Research
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Total 221 results found since Jan 2013.
Interleukin-35 inhibits lipopolysaccharide-induced endothelial cell activation by downregulating inflammation and apoptosis
This study indicated that IL-35 exerts anti-inflammatory and antiapoptotic effects on LPS-induced EC activation by activating the STAT1 and STAT4 signaling pathways.PMID:34508746 | DOI:10.1016/j.yexcr.2021.112784
Source: Experimental Cell Research - September 11, 2021 Category: Cytology Authors: Meng Li Yue Liu Yang Fu Ren Gong Huasong Xia Xiao Huang Yanqing Wu Source Type: research
EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling
Exp Cell Res. 2021 Sep 7:112825. doi: 10.1016/j.yexcr.2021.112825. Online ahead of print.ABSTRACTPodocyte injury is the hallmark of proteinuric glomerular diseases. Notch3 is neo-activated simultaneously in damaged podocytes and podocyte's progenitor cells of FSGS, indicating a unique role of Notch3. We previously showed that activation of cAMP-PKA pathway alleviated podocyte injury possibly via inhibiting Notch3 expression. However, the mechanisms are unknown. In the present study, Notch3 signaling was significantly activated in ADR-induced podocytes in vitro and in PAN nephrosis rats and patients with idiopathic FSGS in ...
Source: Experimental Cell Research - September 10, 2021 Category: Cytology Authors: Kaili Chang Ruqun Xue Minglai Zhao Yuqing Zhao Weien Yu Zhonghua Zhao Xueguang Liu Source Type: research
Dual role of Fam208a during zygotic cleavage and early embryonic development
Exp Cell Res. 2021 Jun 30:112723. doi: 10.1016/j.yexcr.2021.112723. Online ahead of print.ABSTRACTMaintenance of genome stability is essential for every living cell as genetic information is repeatedly challenged during DNA replication in each cell division event. Errors, defects, delays, and mistakes that arise during mitosis or meiosis lead to an activation of DNA repair processes and in case of their failure, programmed cell death, i.e. apoptosis, could be initiated. Fam208a is a protein whose importance in heterochromatin maintenance has been described recently. In this work, we describe the crucial role of Fam208a in ...
Source: Experimental Cell Research - July 3, 2021 Category: Cytology Authors: Veronika Gresakova Vendula Novosadova Michaela Prochazkova Jan Prochazka Radislav Sedlacek Source Type: research
Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/ β-catenin pathway
Exp Cell Res. 2021 Jun 25:112713. doi: 10.1016/j.yexcr.2021.112713. Online ahead of print.ABSTRACTObesity, a global epidemic, is one of the critical causes of chronic kidney disease (CKD). R-spondin1 (RSPO1) possessing the potential to activate Wnt/β-catenin pathway was reported to be elevated in circulation of obesity objects. However, the function of RSPO1 and the latent mechanism in obesity-related CKD are still left to be revealed. In the present study, renal RSPO1 expression was increased in mice fed on high-fat diet (HFD) for 12 weeks. Lentivirus-mediated RSPO1 knockdown partly recovered obesity-related metabolic sy...
Source: Experimental Cell Research - June 28, 2021 Category: Cytology Authors: Xuesong Su Guangyu Zhou Mi Tian Si Wu Yanqiu Wang Source Type: research
Novel small molecule inhibitor of Kpn β1 induces cell cycle arrest and apoptosis in cancer cells
This study investigated the effect of a novel small molecule, Inhibitor of Nuclear Import-60 (INI-60), on cancer cell biology, as well as nuclear import activities associated with Kpnβ1, and cancer progression in vivo using cervical and oesophageal cancer cell lines. INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis. Non-cancer cells were minimally affected by INI-60 at concentrations that inhibited cancer cells. INI-60 treatment altered the localisation of Kpnβ1 and its carg...
Source: Experimental Cell Research - May 21, 2021 Category: Cytology Authors: Aderonke Ajayi-Smith Pauline van der Watt Nonkululeko Mkwanazi Sarah Carden John O Trent Virna D Leaner Source Type: research
Role of NLR Family Pyrin Domain-Containing 3 Inflammasome in the Activation of Pancreatic Stellate Cells
This study revealed that the NLRP3 inflammasome is directly involved in the activation of PSCs in vivo and in vitro. Inhibiting NLRP3 suppresses the activation of PSCs through the TGF-β1/Smad3 pathway.PMID:34004193 | DOI:10.1016/j.yexcr.2021.112634
Source: Experimental Cell Research - May 18, 2021 Category: Cytology Authors: Cai-Xia Li Li-Hua Cui Lan-Qiu Zhang Lei Yang Yu-Zhen Zhuo Nai-Qiang Cui Shu-Kun Zhang Source Type: research
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch
Exp Cell Res. 2021 Apr 15:112598. doi: 10.1016/j.yexcr.2021.112598. Online ahead of print.ABSTRACTDuring orthodontic treatment, mechanical stretch serves a crucial function in osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Up-regulated reactive oxygen species (ROS) level is a result of cyclic mechanical stretch in many cell types. Nuclear factor erythroid-2-related factor-2 (Nrf2) is a master regulator in various antioxidants expression. However, it is not known whether cyclic mechanical stretch could induce the ROS generation in PDLSCs and whether Nrf2 participated in this process. The present stu...
Source: Experimental Cell Research - April 18, 2021 Category: Cytology Authors: Xun Xi Yi Zhao Hong Liu Zixuan Li Shuai Chen Dongxu Liu Source Type: research
