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Condition: Alcoholism

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Total 251 results found since Jan 2013.

Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway
Conclusion Suppression of the TXNIP–NLRP3 inflammasome pathway may partly contribute to the amelioration of hepatic injury during the progression of NASH by honey. Targeting hepatic TXNIP–NLRP3 inflammasome pathway is a potential therapeutic way for the prevention and treatment of NASH.
Source: European Journal of Nutrition - July 2, 2015 Category: Nutrition Source Type: research

Amelioration of Non-alcoholic Fatty Liver Disease by Hepatic Stimulator Substance via Preservation of Carnitine Palmitoyl Transferase-1 Activity.
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1. PMID: 26108664 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 24, 2015 Category: Cytology Authors: Xiao W, Ren M, Zhang C, Li S, An W Tags: Am J Physiol Cell Physiol Source Type: research

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Conclusions: RSV improved hepatic steatosis partially by inducing autophagy in vitro and in vivo, via the cAMP‐PRKA‐AMPK‐SIRT1 signaling pathway, which provides new evidence regarding RSV's effects on NAFLD treatmentThis article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - May 5, 2015 Category: Food Science Authors: Yong Zhang, Ming‐liang Chen, Yong Zhou, Long Yi, Yan‐xiang Gao, Li Ran, Shi‐hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun‐dong Zhu, Qian‐yong Zhang, Man‐tian Mi Tags: Research Article Source Type: research

Essential role of NRF2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.
In conclusion, our work has revealed that in hepatocytes, Nrf2 is an essential early player in the rescue of oxidative stress by LA leading to protection against PA-mediated lipoapoptosis. PMID: 25841776 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 1, 2015 Category: Biology Authors: Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Alfredo Martínez J, Valverde ÁM Tags: Free Radic Biol Med Source Type: research

Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers.
This study might provide a novel therapy for cancer with high-EGFR expression. PMID: 25755827 [PubMed]
Source: American Journal of Translational Research - March 12, 2015 Category: Research Tags: Am J Transl Res Source Type: research

Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease.
Abstract Macrophages play an important role in inflammation and liver injury. In ALD, activated macrophages, including M1 (proinflammatory) and M2 (anti-inflammatory) macrophages, are present in the liver. As KLF4 has been described as a regulator of macrophage polarization, we investigated its role in ALD. Chronic alcohol feeding in C57Bl/6 mice led to increased expression of M1 (TNF-α, MCP1, and IL-1β) and M2 (Arg1, Mrc1, and IL-10) genes and the frequency of CD206(+)CD163(+) M2 macrophages in the liver. KLF4 mRNA and protein levels were increased in the livers of EtFed compared with PF mice. In macrophages, i...
Source: Journal of Leukocyte Biology - March 4, 2015 Category: Hematology Authors: Saha B, Bala S, Hosseini N, Kodys K, Szabo G Tags: J Leukoc Biol Source Type: research

i-Fect Delivers siRNA in vitro and in vivo
In this study data suggest the protective effects of EPO on NUV injuries are highly associated with the increase of p-Cx43, which improves GJIC to reduce neurotoxic substances: Ziyi Zhoua, Xiaobai Weib, Jun Xiang, Junpeng Gao, Lixin Wang, Jinsong You, Yefeng Cai , Dingfang Caid. Protection of erythropoietin against ischemic neurovascular unit injuries through the effects of connexin43. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2015.02...The strands were incubated at 90°C for 5 min and then at 37°C for 1 h. SiRNA was prepared immediately before administration by mixing the RNA solution (1 μg...
Source: Neuromics - February 21, 2015 Category: Neuroscience Tags: Cerebral Ischemia Connexin 43 Delivering siRNA to the CNS EPO HDAC2 i-Fect Stroke Source Type: news

CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration.
We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that co-localize in neurons from the CeA and VTA. To examine the potential role of a TLR4/MCP-1 signal, we used Herpes Simplex Virus (HSV) vectors (amplicons) that retain in vivo neurotropism. Infusion of amplicons for TLR4 or MCP-1 siRNA into the CeA or VTA from the P rats inhibited target gene expression and blunted binge drinking. A similarly delivered amplicon for scrambled siRNA did not inhibit TLR4 or MCP-1 expression nor reduce binge drinking, identifying a neuronal TLR4/MC...
Source: Herpes - January 8, 2015 Category: Infectious Diseases Authors: June HL, Liu J, Warnock KT, Bell KA, Balan I, Bollino D, Puche A, Aurelian L Tags: Neuropsychopharmacology Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Publication date: 2014 Source:Redox Biology, Volume 3 Author(s): Christopher B. Forsyth , Robin M. Voigt , Ali. Keshavarzian Chronic alcohol use can result in many pathological effects including alcoholic liver disease (ALD). While alcohol is necessary for the development of ALD, only 20–30% of alcoholics develop alcoholic steatohepatitis (ASH) with progressive liver disease leading to cirrhosis and liver failure (ALD). This suggests that while chronic alcohol consumption is necessary it is not sufficient to induce clinically relevant liver damage in the absence of a secondary risk factor. Studies in rodent models and ...
Source: Redox Biology - December 14, 2014 Category: Biology Source Type: research

HDAC2 and Anxiety in Alcoholism
The Impact of HDAC2 Gene Expression on AnxietyOur i-Fect Transfection Kit continues to be a potent tool for testing the impact of altered gene expression on behavior. see: SACHIN MOONAT. The Role of Amygdaloid Chromatin and Synaptic Remodeling in Anxiety and Alcoholism. THESIS Submitted as partial fulfillment of the requirements for the degree of Doctor of Philosophy in Neuroscience in the Graduate College of the University of Illinois at Chicago, 2014.The author hypothesized that increased HDAC2 would have a positive impact on anxiety in alchohol preferring (P) rats. Specifically, HDAC2-induced histone modifications ...
Source: siRNA and DsiRNA Transfection Efficiency - November 24, 2014 Category: Neuroscience Tags: Alcoholism Anxiety BDNF Gene Expression Analysis Gene Silencing HDAC2 gene Learning Source Type: news

TGFβ1 Mediates Alcohol‐Induced Nrf2 Suppression in Lung Fibroblasts
ConclusionsAlcohol‐induced oxidative stress is mediated by TGFβ1, which suppresses Nrf2‐ARE‐dependent expression of antioxidant defenses and creates a vicious cycle that feeds back to further increase TGFβ1 expression. These effects of alcohol can be mitigated by activation of Nrf2, suggesting a potential therapy in individuals at risk for lung injury due to alcohol abuse.
Source: Alcoholism: Clinical and Experimental Research - November 24, 2014 Category: Addiction Authors: Viranuj Sueblinvong, Victor Tseng, Tierra Smith, Ramin Saghafi, Stephen T. Mills, David C. Neujahr, David M. Guidot Tags: Original Article Source Type: research

Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Abstract Emerging evidence has indicated that alcohol consumption is an established risk factor for breast cancer. Deregulation of RNA polymerase III (Pol III) transcription enhances cellular Pol III gene production, leading to an increase in translational capacity to promote cell transformation and tumor formation. We have reported that alcohol intake increases Pol III gene transcription to promote cell transformation and tumor formation in vitro and in vivo. Studies revealed that tumor suppressors, pRb, p53, PTEN and Maf1 repress the transcription of Pol III genes. BRCA1 is a tumor suppressor and its mutation is...
Source: Gene - November 8, 2014 Category: Genetics & Stem Cells Authors: Zhong Q, Shi G, Zhang Y, Lu L, Levy D, Zhong S Tags: Gene Source Type: research

Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells
ConclusionsThe results of this study suggest that PS exacerbates acute alcoholic hepatitis by inhibiting apoptosis of activated NKT cells.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2014 Category: Hematology Authors: Ayshwarya‐Lakshmi Chelakkot‐Govindalayathil, Rumi Mifuji‐Moroka, Corina N. D’ Alessandro‐Gabazza, Masaaki Toda, Yoshikazu Matsuda, Paloma Gil‐Bernabe, Ziaurahman Roeen, Taro Yasuma, Yutaka Yano, Esteban C Gabazza, Motoh Iwasa, Yoshiyuki Takei Tags: Original Article ‐ Vascular Biology Source Type: research

Valsartan Blocked Alcohol‐Induced, Toll‐Like Receptor 2 Signaling‐Mediated Inflammation in Human Vascular Endothelial Cells
ConclusionsTLR2 signaling‐mediated alcohol induced inflammatory response in human vascular epithelial cells in vitro, which was inhibited by valsartan.
Source: Alcoholism: Clinical and Experimental Research - October 23, 2014 Category: Addiction Authors: Yushu Wang, Yi Li, Qingyu Shen, Xiangpen Li, Juan Lu, Xiangping Li, Deling Yin, Ying Peng Tags: Original Article Source Type: research