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Condition: Alcoholism
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Total 251 results found since Jan 2013.
Patchouli alcohol improves wound healing in high fat diet-fed mice through AMPK-mediated suppression of inflammation and TGFb1 signaling
Biochem Biophys Res Commun. 2021 May 20;561:136-142. doi: 10.1016/j.bbrc.2021.05.036. Online ahead of print.ABSTRACTObesity impairs wound healing with substantial alterations in skin inflammation. Patchouli alcohol (PA), extracted from patchouli, has been reported to ameliorate inflammation in various cell types. However, the effects of PA on inflammation and wound healing have not been reported to date. In the present study, we examined whether PA affects cutaneous wound healing in high fat diet (HFD)-fed mice and explored PA-mediated molecular mechanisms through in vitro experiments. We found that PA administration accel...
Source: Biochemical and Biophysical Research communications - May 23, 2021 Category: Biochemistry Authors: Tae Jin Kim Do Hyeon Pyun Seung Yeon Park Hyun Jung Lee A M Abd El-Aty Jin-Ho Song Yong Kyoo Shin Ji Hoon Jeong Tae Woo Jung Source Type: research
KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of VTA neurons by ethanol
CONCLUSIONS: KCNK13 plays an important role in ethanol stimulation of rat VTA neurons, and KCNK13 is dynamically regulated by cell damage, by ethanol exposure, and during withdrawal. KCNK13 is a novel alcohol-sensitive protein and further investigation of this channel may offer new avenues for the development of agents useful in altering the rewarding effect of alcohol.PMID:33960499 | DOI:10.1111/acer.14630
Source: Alcoholism, Clinical and Experimental Research - May 7, 2021 Category: Addiction Authors: Chang You Bertha J Vandegrift Mark S Brodie Source Type: research
Cancers, Vol. 13, Pages 1216: Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis
Hideki Wanibuchi
In the present study, potential molecular biomarkers of NASH hepatocarcinogenesis were investigated using the STAM mice NASH model, characterized by impaired insulin secretion and development of insulin resistance. In this model, 2-days-old C57BL/6N mice were subjected to a single subcutaneous (s.c.) injection of 200 μg streptozotocin (STZ) to induce diabetes mellitus (DM). Four weeks later, mice were administered high-fat diet (HFD) HFD-60 for 14 weeks (STAM group), or fed control diet (STZ group). Eighteen-week-old mice were euthanized to allow macroscopic, microscopic, histopathological, immun...
Source: Cancers - March 10, 2021 Category: Cancer & Oncology Authors: Anna Kakehashi Arpamas Chariyakornkul Shugo Suzuki Napaporn Khuanphram Kumiko Tatsumi Shotaro Yamano Masaki Fujioka Min Gi Rawiwan Wongpoomchai Hideki Wanibuchi Tags: Article Source Type: research
MANF Protects Pancreatic Acinar Cells Against Alcohol ‐induced Endoplasmic Reticulum Stress and Cellular injury
ConclusionsMANF was protective against alcohol ‐induced ER stress and cellular injury in pancreatic acinar cells. The findings suggest a potential therapeutic value of MANF for alcoholic pancreatitis.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - March 1, 2021 Category: Gastroenterology Authors: Huaxun Wu,
Hui Li,
Wen Wen,
Yongchao Wang,
Hong Xu,
Mei Xu,
Jacqueline A. Frank,
Wei Wei,
Jia Luo Tags: ORIGINAL ARTICLE Source Type: research
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Abstract
The aim of this study was to investigate how mesenchymal stromal cells (MSCs) modulate metabolic balance and attenuate hepatic lipotoxicity in the context of non-alcoholic fatty liver disease (NAFLD). In vivo, male SD rats were fed with high-fat diet (HFD) to develop NAFLD; then, they were treated twice by intravenous injections of rat bone marrow MSCs. In vitro, HepG2 cells were cocultured with MSCs by transwell and exposed to palmitic acid (PA) for 24 hours. The endoplasmic reticulum (ER) stressor thapsigargin and sarco/ER Ca2+ -ATPase (SERCA2)-specific siRNA were used to explore the regulation of ER s...
Source: J Cell Mol Med - February 16, 2021 Category: Molecular Biology Authors: Li L, Zeng X, Liu Z, Chen X, Li L, Luo R, Liu X, Zhang J, Liu J, Lu Y, Cheng J, Chen Y Tags: J Cell Mol Med Source Type: research
Coordinated regulation of miR-27 by insulin/CREB/Hippo contributes to insulin resistance.
In this study, we attempted to identify the mechanism by which miR-27 was regulated in the context of insulin resistance, a predisposed metabolic disorder in NAFLD. With cell culture experiments and animal studies, our results showed that miR-27 was coordinately regulated by insulin, CREB, and Hippo signalings. First, miR-27 was upregulated in palmitate-treated cells and high fat diet-fed mouse livers, both of which exhibited insulin resistance and increased CREB expression. Second, miR-27 was peaked in mouse liver at post-absorptive phase when CREB activity was increased. Also, miR-27 was increased rapidly in insulin-trea...
Source: Cellular Signalling - January 27, 2021 Category: Cytology Authors: Chen YJ, Chueh LY, Lee SY, Ma PF, Chen PC, Hsu SH Tags: Cell Signal Source Type: research
Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway
Conclusion: These results highlight that NOX4 is a critical mediator of ROS and elaborate the role of the NOX4/ROS axis in the effect of schisandrin B on autophagy and autophagy-mediated apoptosis in acute ethanol exposure, which suggests a therapeutic strategy for acute alcoholic cardiomyopathy.Pharmacology
Source: Pharmacology - January 22, 2021 Category: Drugs & Pharmacology Source Type: research
The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice.
Abstract
Heterologous sensitization of adenylyl cyclase (AC) is defined by an enhanced cAMP response following persistent activation of Gαi/o-coupled receptors. This phenomenon was first observed in cellular models, and later reported in animal models of inflammatory pain or following chronic exposure to drugs of abuse including opioids and cocaine. Recently, we used genome-wide siRNA screening to identify Cullin3 signaling as a mediator of AC sensitization in cellular models. We also showed that pharmacological inhibition of Cullin3 with the neddylation inhibitor, MLN4924, abolished heterologous sensitization of...
Source: Behavioural Brain Research - December 3, 2020 Category: Neurology Authors: Ding Z, Knipp GT, van Rijn RM, Chester JA, Watts VJ Tags: Behav Brain Res Source Type: research
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
CONCLUSIONS: Our results support the existence of a link between the liver cell mitochondria and miR-34a/SIRT1 signaling. Potential endogenous modulators of NAFLD pathogenesis may ultimately provide new tools for therapeutic intervention.
PMID: 33098868 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - October 21, 2020 Category: Biochemistry Authors: Wang L, Sun M, Cao Y, Ma L, Shen Y, Velikanova AA, Li X, Sun C, Zhao Y Tags: Arch Biochem Biophys Source Type: research
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes.
In conclusion, hesperetin protected against palmitate-induced hepatic cell death via activation of the sXBP1/GRP78 signaling pathway, thus inhibiting palmitate-induced ER stress. Moreover, high concentrations of hesperetin induce ER stress and subsequently cause cell death in hepatocytes.
PMID: 32763355 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - August 4, 2020 Category: Toxicology Authors: Geng Y, Wu Z, Buist-Homan M, Blokzijl H, Moshage H Tags: Toxicol Appl Pharmacol Source Type: research
Ethanol antagonizes P2X4 receptors in ventral tegmental area neurons
P2X4 receptors are found throughout the central nervous system, and studies have shown that these purinergic receptors are important regulators of alcohol intake. The ventral tegmental area (VTA) is an important region for the rewarding and reinforcing properties of alcohol, but the role of P2X4 receptors in this region is unknown. Using both immunohistochemical and electrophysiological methods, we examined the interaction between P2X4 receptors and alcohol on VTA neurons. Incubation of brain slices containing the VTA for 2 h with siRNA targeting P2X4 receptors resulted in about a 25% reduction in P2X4 immunoreactivity i...
Source: NeuroReport - July 30, 2020 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Abstract
Alcoholic liver disease (ALD) is the major cause of chronic liver disease and a global health concern. ALD pathogenesis is initiated with liver steatosis, and ALD can progress to steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma. Salvianic acid A (SAA) is a phenolic acid component of Danshen, a Chinese herbal medicine with possible hepatoprotective properties. The purpose of this study was to investigate the effect of SAA on chronic alcoholic liver injury and its molecular mechanism. We found that SAA significantly inhibited alcohol-induced liver injury and ameliorated ethanol-induced...
Source: J Cell Mol Med - June 28, 2020 Category: Molecular Biology Authors: Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, Zhao Y, Wang Z, Zhang N, Yao J Tags: J Cell Mol Med Source Type: research
TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease
ConclusionsAll in all, these experimental outcomes indicated that TMEM88 had an indispensable impact on EtOH-induced secretion of inflammatory cytokines (IL-6 and IL-1 β) in RAW264.7 cells through YAP signaling pathway.
Source: Inflammation Research - May 24, 2020 Category: Research Source Type: research
