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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

TMF protects chondrocytes from ER stress-induced apoptosis by down-regulating GSK-3 β.
TMF protects chondrocytes from ER stress-induced apoptosis by down-regulating GSK-3β. Biomed Pharmacother. 2017 Mar 17;89:1262-1268 Authors: Yuan X, Li L, Shi W, Liu H, Huang X, Liu Z, Wu L Abstract Endoplasmic reticulum (ER) stress-induced chondrocyte apoptosis plays a critical role in osteoarthritis cartilage degeneration. Previous studies showed that 5,7,3',4'-tetramethoxyflavone (TMF) exhibited chondroprotective activity through inhibiting PGE2-induced ER stress and down regulating the expression of GSK-3β. To further investigate the role of GSK-3β in ER stress-induced chondrocytes apoptosis an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 17, 2017 Category: Drugs & Pharmacology Authors: Yuan X, Li L, Shi W, Liu H, Huang X, Liu Z, Wu L Tags: Biomed Pharmacother Source Type: research

SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1 β-Stimulated Human Osteoarthritic Chondrocytes.
In conclusion, IL-4 signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of OA. PMID: 28373981 [PubMed - in process]
Source: Biomed Res - April 5, 2017 Category: Research Authors: He Q, Sun C, Lei W, Ma J Tags: Biomed Res Int Source Type: research

Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway.
Authors: Xue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H Abstract Pterostilbene has been reported as a potential drug to inhibit oxidative stress and inflammation. However, the effect of pterostilbene on chondrocytes and osteoarthritis remains to be elucidated. We sought to investigate whether pterostilbene could protect chondrocytes from inflammation and ROS production through factor erythroid 2-related factor 2 (Nrf2) activation. The pterostilbene toxicity on chondrocytes collected from cartilages of Sprague-Dawley rats was assessed by CCK-8 test. Immunofluorescence and Western blotting explored the nucl...
Source: Oncotarget - April 16, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Transient Receptor Potential Vanilloid 5 Mediates Ca < sup > 2+ < /sup > Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model
Conclusion: Up-regulated TRPV5 as an initiating factor inhibited chondrocyte autophagy via the mediation of Ca2+ influx.Cell Physiol Biochem 2017;42:319 –332
Source: Cellular Physiology and Biochemistry - May 23, 2017 Category: Cytology Source Type: research

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis
This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration and matrix synthesis of the chondrocytes. The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via PERK‐regulated UPR and suggest a potential therapeutic application of MGF for OA treatment. This article is protected by copyright. All rights reserved.
Source: Journal of Tissue Engineering and Regenerative Medicine - June 9, 2017 Category: Biotechnology Authors: Yang Song, Kang Xu, Can Yu, Lili Dong, Peixing Chen, Yonggang Lv, Martin Y.M. Chiang, Linhao Li, Wanqian Liu, Li Yang Tags: RESEARCH ARTICLE Source Type: research

LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes Research
In this study, we assessed the role of SIRT1 in LEF1-mediated MMP13 gene expression in human OA chondrocytes. Results showed that MMP13 protein levels and enzymatic activity decreased significantly during SIRT1 overexpression or activation by resveratrol. Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor. Chondrocytes challenged with IL-1β, a cytokine involved in OA pathogenesis, enhanced LEF1 protein levels and gene expression, resulting in increased MMP13 gene expression; however, overexpression of SIRT1 during IL-1&beta...
Source: FASEB Journal - June 29, 2017 Category: Biology Authors: Elayyan, J., Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. Tags: Research Source Type: research

Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R
AbstractIn recent years, some studies have been made on the effects of circular RNA (circRNA) in osteoarthritis (OA) and so on; however, its mechanisms remain to be further explored. Studies have shown that tumor necrosis factor-alpha can inhibit hsa_circ_0045714 expression in chondrocytes so as to upregulate miR-193b expression. Dual-luciferase reporter assay showed that insulin-like growth factor 1 receptor (IGF1R) is a key target gene of miR-193b. Hsa_circ_0045714 over-expression does not influence miR-193b expression, but can inhibit its transcriptional activity, thereby upregulating IGF1R expression. Hsa_circ_0045714 ...
Source: Human Cell - August 9, 2017 Category: Cytology Source Type: research

Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Publication date: Available online 10 August 2017 Source:Steroids Author(s): Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes ind...
Source: Steroids - August 10, 2017 Category: Drugs & Pharmacology Source Type: research

MiR-337-3p promotes chondrocytes proliferation and inhibits apoptosis by regulating PTEN/AKT axis in osteoarthritis.
CONCLUSION: MiR-337-3p regulated OA chondrocytes proliferation through PTEN/AKT axis and thus involved in OA. PMID: 28931211 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2017 Category: Drugs & Pharmacology Authors: Huang Z, Zhang N, Ma W, Dai X, Liu J Tags: Biomed Pharmacother Source Type: research

Oxidized low density lipoprotein facilitates tumor necrosis factor ‑α mediated chondrocyte death via autophagy pathway.
Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway. Mol Med Rep. 2017 Oct 13;: Authors: Shen P, Zhu Y, Zhu L, Weng F, Li X, Xu Y Abstract We aimed to investigate the role of oxidized low density lipoprotein (ox‑LDL) in tumor necrosis factor‑α (TNF‑α) mediated chondrocyte death and explore the mechanisms. Ten osteoarthritis (OA) and normal control cartilage tissue and synovial fluid (SF) samples were collected, and the expression of lectin‑like ox‑LDL receptor‑1 (LOX‑1) and ox‑LDL level was examined by real time quan...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Anti-Inflammatory Effects of Licochalcone A on IL-1 β-Stimulated Human Osteoarthritis Chondrocytes
In conclusion, our re sults suggested that Lico A showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.
Source: Inflammation - October 25, 2017 Category: Allergy & Immunology Source Type: research

PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis.
Abstract 3-Phosphoinositide dependent protein kinase-1 (PDK1), a serine threonine kinase, belongs to the AGC kinase family and is associated with apoptosis. The aim of this study was to investigate the expression of PDK1 (3-Phosphoinositide dependent protein kinase-1) in articular cartilage with osteoarthritis (OA) and to analyze the relationship between PDK1 and chondrocyte apoptosis. Immunohistochemistry and RT-PCR analysis showed that the expression of PDK1 in articular cartilage of OA patients and healthy controls. IL-1β-stimulated SW1353 cells were used to imitate the OA-like chondrocyte injury in vitro, and...
Source: Tissue and Cell - October 18, 2017 Category: Cytology Authors: Ge Q, Wang H, Xu X, Xu L, Zhai L, Tao R Tags: Tissue Cell Source Type: research

Saikosaponin A inhibits IL-1 β-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRα.
In conclusion, our results demonstrated that SSa inhibited inflammatory responses in human chondrocytes in vitro. SSa might be a potential therapeutic drug for osteoarthritis. PMID: 29179489 [PubMed]
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
Abstract Aging is closely associated with osteoarthritis (OA). Although its underlying mechanisms remain unknown, cellular senescence in chondrocytes has become an important therapeutic target for the treatment of OA. Cysteinyl leukotriene receptors (cysLTRs) mediate the pathobiological function of cysteinyl leukotrienes (cysLTs). However, the roles of cysLTRs in the pathogenesis of OA have not been reported before. In the current study, we found that cysLTR1 but not cysLTR2 is expressed in human primary chondrocytes. In addition, stimulation with tumor necrosis factor α (TNF-α) resulted in a significant increas...
Source: Cytokine - January 10, 2018 Category: Molecular Biology Authors: Song W, Zhang Y, Wang J, Ma T, Hao L, Wang K Tags: Cytokine Source Type: research

Role of IFT88 in icariin ‑regulated maintenance of the chondrocyte phenotype.
Role of IFT88 in icariin‑regulated maintenance of the chondrocyte phenotype. Mol Med Rep. 2018 Jan 25;: Authors: Xiang W, Zhang J, Wang R, Wang L, Wang S, Wu Y, Dong Y, Guo F, Xu T Abstract Maintenance of the chondrocyte phenotype is crucial for cartilage repair during tissue engineering. Intraflagellar transport protein 88 (IFT88) is an essential component of primary cilia, shuttling signals along the axoneme. The hypothesis of the present study was that IFT88 could exert an important role in icariin‑regulated maintenance of the chondrocyte phenotype. To this end, the effects of icariin on prolife...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research