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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1
CONCLUSION: We propose a novel regulatory mechanism underlying mechanical stress-mediated apoptosis of chondrocyte and elucidate the potential application value of GPER as therapy targets for OA.PMID:34454425 | DOI:10.1186/s10020-021-00360-w
Source: Molecular Medicine - August 29, 2021 Category: Molecular Biology Authors: Yi Sun Ping Leng Pengcheng Guo Huanshen Gao Yikai Liu Chenkai Li Zhenghui Li Haining Zhang Source Type: research

Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF- κB p65
CONCLUSION: A20 was reduced in OA cartilage samples, and its overexpression, by suppressing the activity of NF-κB p65, could improve IL-1β-induced chondrocyte degradation and apoptosis in vitro, as well as mitigate the inflammation in OA mice.PMID:34463587 | DOI:10.1080/08923973.2021.1970764
Source: Immunopharmacology and Immunotoxicology - August 31, 2021 Category: Allergy & Immunology Authors: Shu-Bei Cui Tao-Xia Wang Zhen-Wu Liu Ji-Ying Yan Kai Zhang Source Type: research

Platelet-rich plasma attenuates interleukin-1 β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α
Tissue Cell. 2021 Sep 8;73:101646. doi: 10.1016/j.tice.2021.101646. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a prevailing chronic disease in Orthopedics that characterized with severely damaged cartilage and subchondral bone, thus leading to profound disorders of synovial joints. Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from interleukin-1β (IL-1β)-induced apoptosis in vitro. However, the underlying mechanism behind the treatment remains unclear. The current study...
Source: Tissue and Cell - September 18, 2021 Category: Cytology Authors: Jinjiang Yang Ai Guo Qiang Li Jie Wu Source Type: research

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression
Conclusions Our study revealed the important role of FLS senescence in OA progression. Targeted METTL3 inhibition could alleviate the senescence of FLS and limit OA development in experimental animal models, providing a potential strategy for OA therapy.
Source: Annals of the Rheumatic Diseases - January 4, 2022 Category: Rheumatology Authors: Chen, X., Gong, W., Shao, X., Shi, T., Zhang, L., Dong, J., Shi, Y., Shen, S., Qin, J., Jiang, Q., Guo, B. Tags: ARD, Osteoarthritis Source Type: research

Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPK α-SIRT1-PGC-1α Pathway
Conclusion: Taken together, AGEs reduced the AMPK α/SIRT1/PGC-1α signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress, inflammation, and apoptosis. These results indicated that target AMPK may be as a novel therapeutic strategy for AGEs-related OA prevention.Pharmacology
Source: Pharmacology - March 3, 2022 Category: Drugs & Pharmacology Source Type: research

Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress
This study investigated the effects of VAL on lipid accumulation and lipogenesis in human primary hepatocytes. Treatment with VAL suppressed lipid accumulation and expressions of lipogenic genes, such as processed sterol regulatory element binding proteins (SREBP1) and stearoyl-CoA desaturase-1 (SCD1) in palmitate-treated hepatocytes. Furthermore, VAL ameliorated dose-dependently palmitate-induced ER stress markers. Treatment of hepatocytes with VAL increased AMPK phosphorylation and SIRT6 expression. siRNA-mediated suppression of AMPK or SIRT6 abolished the effects of VAL on lipid accumulation, lipogenesis, and endoplasmi...
Source: Biochemical Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Authors: Seung Yeon Park Wonjun Cho A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Tae Woo Jung Source Type: research

Indirubin relieves inflammatory injury of chondrocytes in a mouse model of osteoarthritis
CONCLUSION: Indirubin has a protective effect on osteoarthritis tissue and alleviates inflammation and damage of osteoarthritis chondrocytes possibly through NPAS2.PMID:36210712 | DOI:10.12122/j.issn.1673-4254.2022.09.15
Source: Journal of Southern Medical University - October 10, 2022 Category: Universities & Medical Training Authors: X Chen X Qi Y Cao Y Li H Li Q Wang J Ai Source Type: research

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
CONCLUSION: CAT-1 is upregulated and promotes FLS proliferation by taking up L-arginine, thereby promoting RA progression.PMID:36253807 | DOI:10.1186/s13075-022-02921-8
Source: Cell Research - October 17, 2022 Category: Cytology Authors: Ying Lu Chongbo Hao Shanshan Yu Zuan Ma Xuelian Fu Mingqing Qin Menglei Ding Zengguang Xu Lieying Fan Source Type: research