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Condition: Nephritis

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Total 28 results found since Jan 2013.

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
Discussion Dynamic changes in the functional phenotype of macrophages are associated with pathogenesis of inflammatory diseases (5–7). TonEBP primes macrophages toward an M1 phenotype, which has pro-inflammatory properties. TonEBP does this by promoting expression of pro-inflammatory genes via interaction with NF-κB (36) and by binding directly to the promoter (37, 64). In addition, TonEBP suppresses expression of the anti-inflammatory cytokine IL-10 by limiting chromatin access to the promoter (37). The pro-inflammatory function of TonEBP suggests that inhibiting its expression or activation could suppres...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Lupus Nephritis: Glycogen Synthase Kinase 3β Promotion of Renal Damage Through Activation of the NLRP3 Inflammasome in Lupus‐Prone Mice
ConclusionThese results show that GSK‐3β promotes lupus nephritis at least partly by activating the NLRP3/IL‐1β pathway. The linking of GSK‐3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK‐3β/NLRP3/IL‐1β pathway may be a potential therapeutic target for lupus in humans.
Source: Arthritis and Rheumatism - March 27, 2015 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
ConclusionActivation of the P2X7 signaling pathway accelerates murine LN by activating the NLRP3/ASC/caspase 1 inflammasome, resulting in increased IL‐1β production and enhanced Th17 cell polarization. Thus, targeting of the P2X7/NLRP3 pathway should be considered as a novel therapeutic strategy in patients with lupus.
Source: Arthritis and Rheumatism - November 27, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

Lupus nephritis: Glycogen synthase kinase 3β promotes renal damage through activation of NLRP3 inflammasome in lupus‐prone mice
Conclusion. These results show that GSK3β promotes LN, at least in part, by activating the NLRP3/IL‐1β pathway. The linking of GSK3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK3β/NLRP3/IL‐1β pathway may be potential therapeutic targets for human lupus. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 15, 2014 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research

Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis.
Abstract Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequently, we have studied the efficacy and mechanism of R428, a potent selective Axl inhibitor, in the prevention of experimental anti-GBM nephritis. Axl upregulation was investigated with Sp1/3 siRNA in the SV40-transformed mesangial cells. For Axl inhibition, a daily dose of R428 (125 mg/kg) or vehicle was administered orally. GN was induced with anti-GBM sera. R...
Source: Journal of Autoimmunity - June 9, 2018 Category: Allergy & Immunology Authors: Zhen Y, Lee IJ, Finkelman FD, Shao WH Tags: J Autoimmun Source Type: research

053 Molecular mechanism of miR-145/Smad3 pathway mediated by active vitamin D in Lupus Nephritis
To elucidate the roles of 1,25(OH)2D3 and VDR in the pathogenesis of Lupus Nephritis (LN) by regulating miR-145 expression through TGF- β1-dependent Smad3 signaling pathway.From January 1, 2012 to January 1, 2017, 49 children (11 males and 38 females) with LN and 50 healthy controls were selected in this study. CD4+Tcells treated with different concentrations of 1,25(OH)2D3(1×10-6mmol/L,1×10-7mmol/L,1×10-8mmol/L).VDR-siRNA inter ference vector and human VDR overexpression vector were constructed. CD4+T cells in logarithmic growth phase were divided into 6 groups: the normal control group, the normal negative control (N...
Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: Y. Ding, X. He Tags: Adaptive and Auto-Immunity Source Type: research

Pim ‐1 As a Therapeutic Target in Lupus Nephritis
ConclusionThese data identify Pim ‐1 as a critical regulator of LN pathogenesis in patients with SLE. Targeting of the Pim‐1/NFATc1/NLRP3 pathway might therefore have therapeutic potential in human LN.
Source: Arthritis and Rheumatology - July 1, 2019 Category: Rheumatology Authors: Rong Fu, Yong Xia, Meirong Li, Renxiang Mao, Chaohuan Guo, Mianjing Zhou, Hechang Tan, Meiling Liu, Shuang Wang, Niansheng Yang, Jijun Zhao Tags: Original Article Source Type: research

(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/ β-catenin pathways in glomerulonephritis.
(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/β-catenin pathways in glomerulonephritis. Am J Physiol Renal Physiol. 2020 Aug 24;: Authors: Urushihara M, Kondo S, Kinoshita Y, Ozaki N, Jamba A, Nagai T, Fujioka K, Hattori T, Kagami S Abstract (Pro)renin receptor ((P)RR) has multiple functions, but its regulation and role in the pathogenesis in glomerulonephritis (GN) are poorly defined. The aims of this study were to determine the effects of direct renin inhibition (DRI) and demonstrate the role of (P)RR on the progression of crescentic GN. Anti-glomerular basement membrane (G...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Urushihara M, Kondo S, Kinoshita Y, Ozaki N, Jamba A, Nagai T, Fujioka K, Hattori T, Kagami S Tags: Am J Physiol Renal Physiol Source Type: research

Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice.
In conclusion, our research demonstrated that the upregulation of FoxO3a expression through inhibiting PI3K/Akt pathway attenuates murine lupus nephritis (LN). Thus, our results suggest that targeting of FoxO3a can be considered as a novel strategy for the treatment of LN. PMID: 33039957 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - October 8, 2020 Category: Allergy & Immunology Authors: Zhao C, Gu Y, Chen L, Su X Tags: Int Immunopharmacol Source Type: research

YAP1 Overexpression Is Associated with Kidney Dysfunction in Lupus Nephritis
Conclusion: YAP1 expression in the kidney tissues of LN mice was higher than that observed in normal mice, indicating that YAP1 may play an important role in the occurrence and development of LN.Pathobiology
Source: Pathobiology - August 3, 2021 Category: Pathology Source Type: research

CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis
This study provides insights into the pathogenic mechanisms of LN and that CRAC channel could serve as a potential therapeutic target for LN.
Source: Frontiers in Immunology - October 22, 2021 Category: Allergy & Immunology Source Type: research

P2X7 blockade attenuates lupus nephritis by inhibiting NLRP3/ASC/caspase‐1 activation
Conclusion. Activation of the P2X7 signaling pathway accelerates murine LN by activating NLRP3/ASC/caspase‐1 inflammasome, resulting in increased IL‐1β and enhanced Th17 cell polarization. Thus, targeting the P2X7/NLRP3 pathway as a therapeutic strategy for lupus patients should be considered. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 10, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research

A critical role for SOCS3 in promoting M1 macrophage activation and function in vitro and in vivo.
This article is protected by copyright. All rights reserved. PMID: 24088176 [PubMed - as supplied by publisher]
Source: Immunology - September 21, 2013 Category: Allergy & Immunology Authors: Arnold CE, Whyte CS, Gordon P, Barker RN, Rees AJ, Wilson HM Tags: Immunology Source Type: research

The PTEN/PI3K/Akt signalling pathway mediates HMGB1-induced cell proliferation by regulating the NF-κB/cyclin D1 pathway in mouse mesangial cells.
Abstract Our previous experiment confirmed that high mobility group box chromosomal protein 1 ( HMGB1 ) was involved in the pathogenesis of Lupus nephritis ( LN ) by up-regulating the proliferation of mouse mesangial cells ( MMC ) through the cyclin D1/CDK4/p16 system, but the precise mechanism is still unknown. Thereforein the present study, we demonstrated that HMGB1 induced the proliferation of MMC in time- and concentration-dependent manner, down-regulated phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) expression, increased the level of Akt serine 473 phosphorylation, and induced p65 subunit...
Source: American Journal of Physiology. Cell Physiology - April 23, 2014 Category: Cytology Authors: Feng XJ, Liu SX, Wu C, Kang PP, Liu Q, Hao J, Li HB, Li F, Zhang Y, Fu XH, Zhang SB, Zuo LF Tags: Am J Physiol Cell Physiol Source Type: research

Experimental acute kidney injury
Conclusions: WNT10A expression may promote fibrotic progression and kidney dysfunction in AIN. Blockade of WNT10A expression may be a feasible therapeutic strategy against kidney fibrosis.
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Kuma, A., Yamada, S., Miyamoto, T., Serino, R., Tamura, M., Otsuji, Y., Kohno, K., Cho, W. Y., Kim, M.-G., Jo, S.-K., Kim, H. K., Jado, J. C., Humanes, B., Lopez-Parra, V., Camano, S., Lara, J. M., Cercenado, E., Tejedor, A., Lazaro, A., Jansen, M., Caste Tags: Sunday, June 1st, 2014: Posters Source Type: research