Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice.

In conclusion, our research demonstrated that the upregulation of FoxO3a expression through inhibiting PI3K/Akt pathway attenuates murine lupus nephritis (LN). Thus, our results suggest that targeting of FoxO3a can be considered as a novel strategy for the treatment of LN. PMID: 33039957 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33039957?dopt=Abstract

Source: International Immunopharmacology - October 8, 2020 Category: Allergy & Immunology Authors: Zhao C, Gu Y, Chen L, Su X Tags: Int Immunopharmacol Source Type: research