P2X7 blockade attenuates lupus nephritis by inhibiting NLRP3/ASC/caspase‐1 activation

Conclusion. Activation of the P2X7 signaling pathway accelerates murine LN by activating NLRP3/ASC/caspase‐1 inflammasome, resulting in increased IL‐1β and enhanced Th17 cell polarization. Thus, targeting the P2X7/NLRP3 pathway as a therapeutic strategy for lupus patients should be considered. © 2013 American College of Rheumatology.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fart.38174

Source: Arthritis and Rheumatism - September 10, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research