Distribution and clinical significance of HPV16 variants in head and neck squamous cell carcinomas: data from a Portuguese cohort and systematic review
Conclusion: These results provide a comprehensive genomic map of HPV16 in HSNCC, highlighting tissue-specific characteristics which will help design tailored therapies for cancer patients. (Source: Pathobiology)
Source: Pathobiology - April 11, 2023 Category: Pathology Source Type: research
Disruptive and truncating TP53 mutations are associated with African-ancestry and worse prognosis in Brazilian patients with lung adenocarcinoma
CONCLUSION: TP53 mutations are common in Brazilian lung adenocarcinomas, and their biological characterization as disruptive and truncating mutations is associated with African ancestry and shorter overall survival. (Source: Pathobiology)
Source: Pathobiology - April 8, 2023 Category: Pathology Source Type: research
High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer
Conclusion: High INCENP expression is a poor prognostic biomarker in BC with potential therapeutic benefits. (Source: Pathobiology)
Source: Pathobiology - April 7, 2023 Category: Pathology Source Type: research
High Inner Centromere Protein (INCENP) expression correlates with aggressive features and predicts poor prognosis in patients with invasive breast cancer
This study aims to evaluate the clinical and prognostic significance of INCENP in invasive breast cancer (BC).
Material and Methods: INCENP protein expression was evaluated on a tissue microarray of a large BC cohort (n=1295) using immunohistochemistry. At the mRNA level, INCENP expression was assessed using the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (n=1980) and Cancer Genome Atlas (TCGA) BC cohorts (n=854). The correlations between INCENP expression, clinicopathological parameters and patient outcome were investigated.
Results: INCENP protein expression was detected in the nucleus and c...
Source: Pathobiology - April 7, 2023 Category: Pathology Source Type: research
Senescent Tumor Cells Are Frequently Present at the Invasion Front: Implications for Improving Disease Control in Patients with Locally Advanced Prostate Cancer
Conclusion: This proof-of-concept study shows that invading prostate cancer cells frequently show signs of cellular senescence. This finding may open new avenues for neoadjuvant and adjuvant treatment concepts in men with locally advanced prostate cancer. (Source: Pathobiology)
Source: Pathobiology - March 31, 2023 Category: Pathology Source Type: research
Senescent tumor cells are frequently present at the invasion front - implications for improving disease control in patients with locally advanced prostate cancer
Conclusion: This proof-of-concept study shows that invading prostate cancer cells frequently show signs of cellular senescence. This finding may open new avenues for neoadjuvant and adjuvant treatment concepts in men with locally advanced prostate cancer. (Source: Pathobiology)
Source: Pathobiology - March 31, 2023 Category: Pathology Source Type: research
Myeloid proliferations associated with Down syndrome: clinicopathologic characteristics of forty cases from five large academic institutions
Objectives: The incidence of myelodysplastic syndrome and acute myeloid leukemia is significantly increased in children with Down syndrome (DS). Within the revised 2016 WHO edition, these entities are jointly classified as myeloid leukemia associated with DS (ML-DS). Additionally, infants with DS may develop transient abnormal myelopoiesis (TAM) which is histomorphologically identical to ML-DS. While TAM is self-limiting, it is associated with an increased risk of subsequently developing ML-DS. Differentiating TAM and ML-DS is challenging but clinically critical.
Methods: We performed a retrospective review of ML-DS and ...
Source: Pathobiology - March 30, 2023 Category: Pathology Source Type: research
Primary Effusion Lymphoma in an HIV-Negative Patient with Chronic Myeloid Leukemia Treated with Dasatinib
We report a case of PEL in a young, relatively immunocompetent patient with no history of organ transplant receiving dasatinib for CML, BCR::ABL1-positive.
Discussion: We hypothesize that the loss of T-cell function secondary to TKI therapy (dasatinib) may have resulted in the unchecked cellular proliferation of KSHV-infected cells, leading to the emergence of a PEL. We recommend cytologic investigation and KSHV testing in patients being treated with dasatinib for CML who present with persistent or recurrent effusions. (Source: Pathobiology)
Source: Pathobiology - March 30, 2023 Category: Pathology Source Type: research
< i > NPM1 < /i > -Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions
Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype AMLs. Earlier World Health Organization (WHO) classification schema recognizedNPM1-mutated AMLs as a unique subtype of AML, while the latest WHO and International Consensus Classification (ICC) now considerNPM1 mutations as AML-defining, albeit at different blast count thresholds.NPM1 mutational load correlates closely with disease status, particularly in the post-therapy setting, and therefore high sensitivity-based methods for detection of the mutant allel...
Source: Pathobiology - March 21, 2023 Category: Pathology Source Type: research
NPM1-mutated acute myeloid leukemia: recent developments and open questions
Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de novo acute myeloid leukemias (AML), and are relatively enriched in normal karyotype (NK) AMLs. Earlier World Health Organization (WHO) classification schema recognized NPM1-mutated AMLs as a unique subtype of AML, while the latest WHO and International Consensus Classification (ICC) now consider NPM1 mutations as AML-defining, albeit at different blast count thresholds. NPM1 mutational load correlates closely with disease status, particularly in the post-therapy setting, and therefore high sensitivity-based methods for detection of the muta...
Source: Pathobiology - March 21, 2023 Category: Pathology Source Type: research
Artificial intelligence in bone marrow histological diagnostics: potential applications and challenges
The expanding digitalization of routine diagnostic histological slides holds a potential to apply artificial intelligence (AI) to pathology, including bone marrow (BM) histology. In this perspective we describe potential tasks in diagnostics that can be supported, investigations that can be guided and questions that can be answered by the future application of AI on whole slide images of BM biopsies. These range from characterization of cell lineages and quantification of cells and stromal structures to disease prediction. First glimpses show an exciting potential to detect subtle phenotypic changes with AI that are due to...
Source: Pathobiology - February 15, 2023 Category: Pathology Source Type: research
Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine
This article is aimed to share the information for the proper handling of cytological specimens in practice for genomic medicine based on the findings established in “Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine (in Japanese)” published by the Japanese Society of Clinical Cytology in 2021. The three-part practical guidelines are based on empirical data analyses; Part 1 describes general remarks on the use of cytological specime ns in cancer genomic medicine, then Part 2 describes proper handling of cytological specimens, and Part 3 describes the empirical data related to handling of cytol...
Source: Pathobiology - February 8, 2023 Category: Pathology Source Type: research
Blood Liquid Biopsy in an Advanced Medullary Thyroid Carcinoma: A Case Study with Rearranged during Transfection Heterogeneity
Conclusion: Liquid biopsy makes it possible to analyze different genetic alterations that may have implications as predictive factors. It also reveals tumor heterogeneity and its implications for prognostic factors.Pathobiology (Source: Pathobiology)
Source: Pathobiology - February 2, 2023 Category: Pathology Source Type: research
Clinical and Prognostic Impact of the Warburg Effect in Esophageal Carcinoma: Monocarboxylate Transporters as Candidates for Therapeutic Targeting
Conclusion: Elevated glycolytic rates correlate with a poor clinicopathological profile in EC patients. MCT4 and CAIX positivity independently predict a worse prognosis. Due to the lack of information on treatment modalities, we could not further infer the role of these biomarkers in predicting response to therapy, which needs to be assessed in future studies. In addition, MCT1/4 targeting should be performed both “in vitro” and “in vivo” to further explore its impact on tumor growth and response to classical therapies. HKII expression and function, particularly in the tumor stroma, should be investigated.Pathobiol...
Source: Pathobiology - February 1, 2023 Category: Pathology Source Type: research
Clinical Value of Platelets and Coagulation Parameters in Predicting the Severity of Delta Variant SARS-CoV-2
Conclusion: Low platelet may be a marker of disease severity in Delta variant SARS-CoV-2 and may contribute to determine the severity of patients infected with Delta.Pathobiology (Source: Pathobiology)
Source: Pathobiology - February 1, 2023 Category: Pathology Source Type: research
