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Condition: Heart Disease
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Total 126 results found since Jan 2013.
Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease.
CONCLUSIONS: We demonstrated RSV had anti-inflammatory effects on HCAECs via induction of autophagy. Our results suggest that resveratrol may modulate the inflammatory response of coronary artery in KD and explore the role of autophagy in the pathogenesis and alternative therapy of coronary arterial lesions in KD.
PMID: 28069066 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - January 13, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Conclusion: VPA could inhibit Hdac1/2/3, Vangl2/Scrib, or total Hdac activity both in vitro and in vivo and Hdac3 might participate in the process of VPA-induced cardiac developmental anomalies.
PMID: 30127218 [PubMed - in process]
Source: Chinese Medical Journal - August 23, 2018 Category: General Medicine Authors: Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C Tags: Chin Med J (Engl) Source Type: research
Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research
miR-17 regulates the proliferation and apoptosis of endothelial cells in coronary heart disease via targeting insulin-like-growth factor 1
Publication date: Available online 20 June 2019Source: Pathology - Research and PracticeAuthor(s): Zhongpu Chen, Xiaodong Pan, Zulong Sheng, Gaoliang Yan, Long Chen, Genshan MaAbstractCoronary heart disease (CHD) is one of the main risks of death, which is mainly caused by coronary arteries arteriosclerosis. The present study aims to investigate the potential roles of miR-17 in CHD. In the present study, Human umbilical vascular endothelial cells (HUVECs) were treated with oxidized low density lipoprotein (ox-LDL). qRT-PCR and western blot were used to examine the mRNA and protein levels, respectively. CCK-8 and flow cytom...
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research
Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission
In this study, we established a myocardial ischemia/reperfusion (I/R) rat model. Rat hearts exposed to Sal with or without compound C were then subjected to I/R. Further, H9c2 cardiomyocytes were subjected to simulated ischemia/reperfusion (SIR) by hypoxia-reoxygenation. The rats and cardiomyocytes were pretreated with Sal, followed by Compound C and AMPK-siRNA to block AMPK activity. We found that Sal significantly ameliorated cardiac function, mitigated infarct size and serum content of lactate dehydrogenase and creatine kinase, improved mitochondrial function, and reduced mitochondrial fission and apoptosis. Furthermore...
Source: Toxicology and Applied Pharmacology - June 6, 2022 Category: Toxicology Authors: Xin Tian Ye Huang Xiaofeng Zhang Rong Fang Yi Feng Wanfang Zhang Ling Li Tian Li Source Type: research
MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration
Highlights: ► miR-21 expression was upregulated by rapamycin treatment. ► miR-21 deletion abolished rapamycin-induced inhibition on endothelial growth and mobility. ► RhoB was a direct target gene of miR-21. ► Knock-down of Raptor mimicked the augmentation of miR-21 induced by rapamycin.Abstract: Rapamycin suppresses endothelial proliferation and migration, which leads to delayed re-endothelialization in the rapamycin-eluted stents that are used in coronary heart disease patients. Because microRNAs (miRs) play important roles in endothelial angiogenesis, we tested the hypothesis that rapamycin induces endothelial s...
Source: FEBS Letters - January 9, 2013 Category: Biochemistry Authors: Chongying Jin, Yanbo Zhao, Lu Yu, Shengjie Xu, Guosheng Fu Tags: Research Letters Source Type: research
Far-infrared radiation acutely increases nitric oxide production by increasing Ca(2+) mobilization and Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphorylation of endothelial nitric oxide synthase at serine 1179.
This study suggests that FIR radiation increases NO production via increasing CaMKII-mediated eNOS-Ser(1179) phosphorylation but TRPV channels may not be involved in this pathway. Our results may provide the molecular mechanism by which FIR radiation improves endothelial function.
PMID: 23756809 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 8, 2013 Category: Biochemistry Authors: Park JH, Lee S, Cho DH, Kang DH, Jo I Tags: Biochem Biophys Res Commun Source Type: research
Transcription factor Kruppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation
Conclusion
Up-regulation of KLF2 by AMPK activation constitutes a novel mechanism of ECFC differentiation, and may have therapeutic value in the treatment of ischaemic heart disease.
Source: Cardiovascular Research - July 22, 2013 Category: Cardiology Authors: Song, Y., Li, X., Wang, D., Fu, C., Zhu, Z., Zou, M.-H., Zhu, Y. Tags: Vascular biology Source Type: research
GRK5 Regulation of NF-{kappa}B Signaling Signal Transduction
G protein-coupled receptor kinase 5 GRK5 plays a key role in regulating cardiac signaling and its expression is increased in heart failure. GRK5 activity in the nucleus of myocytes has been shown to be detrimental in the setting of pressure-overload hypertrophy. The ubiquitous nuclear transcription factor κB (NF-κB) is involved in the regulation of numerous genes in various tissues, and activation of NF-κB has been shown to be associated with heart disease. Herein, we investigated whether GRK5 can specifically regulate the NF-κB signaling pathway in myocytes. We found that overexpression of GRK5 increased the levels of...
Source: Journal of Biological Chemistry - December 13, 2013 Category: Chemistry Authors: Islam, K. N., Bae, J.-W., Gao, E., Koch, W. J. Tags: Gene Regulation Source Type: research
Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance.
CONCLUSIONS: A mutual enhancement between DRP1 and ROS could promote mitochondrial dysfunction and inhibition of insulin signal transduction. However, other mechanisms, including lipid metabolite-induced mitochondrial dysfunction, may be involved in palmitate-induced insulin resistance.
PMID: 24631294 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - March 11, 2014 Category: Cytology Authors: Watanabe T, Saotome M, Nobuhara M, Sakamoto A, Urushida T, Katoh H, Satoh H, Funaki M, Hayashi H Tags: Exp Cell Res Source Type: research
Bone Morphogenetic Protein‐10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein‐10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. After stimulation with the recombinant BMP10, an obvious dose‐dependent cardiomyocyte proliferation and reentry of differentiated mammalian cardiomyocytes into the cell cycle was observed. Furthermore, BMP10 stimulation strikingly enhanced Tbx20 expression. Fu...
Source: Journal of Cellular Biochemistry - June 6, 2014 Category: Biochemistry Authors: Lijun Sun, Jing Yu, Shun Qi, Yuewen Hao, Ying Liu, Zhenwu Li Tags: Article Source Type: research
Vasonatrin peptide attenuates myocardial ischemia/reperfusion injury in diabetic rats and underlying mechanisms.
Conclusions: VNP protects diabetic heart against ischemia/reperfusion injury by inhibiting ER stress via cGMP-PKG signaling pathway. These results suggest that VNP may have potential therapeutic value for the diabetic patients with ischemic heart disease.
PMID: 25485902 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 5, 2014 Category: Physiology Authors: Shi Z, Fu F, Yu L, Xing W, Ji L, Tie R, Liang X, Zhu M, Yu J, Zhang H Tags: Am J Physiol Heart Circ Physiol Source Type: research
Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function Coronary Heart Disease
Conclusions
Our data implicate that heparan sulfate elongation genes EXT1 and EXT2 are involved in maintaining endothelial homeostasis, presumably via increased nitric oxide bioavailability.
Source: JAHA:Journal of the American Heart Association - December 2, 2014 Category: Cardiology Authors: Mooij, H. L., Cabrales, P., Bernelot Moens, S. J., Xu, D., Udayappan, S. D., Tsai, A. G., van der Sande, M. A. J., de Groot, E., Intaglietta, M., Kastelein, J. J. P., Dallinga-Thie, G. M., Esko, J. D., Stroes, E. S., Nieuwdorp, M. Tags: Coronary Heart Disease Source Type: research
Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms
This study was designed to investigate the effects of VNP on ischemia-reperfusion injury in diabetic rats and to further elucidate its mechanisms. The high-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats were subjected to ischemia-reperfusion operation. VNP treatment (100 μg/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Moreover, VNP inhib...
Source: AJP: Heart and Circulatory Physiology - February 15, 2015 Category: Cardiology Authors: Shi, Z., Fu, F., Yu, L., Xing, W., Su, F., Liang, X., Tie, R., Ji, L., Zhu, M., Yu, J., Zhang, H. Tags: CALL FOR PAPERS Source Type: research
IDHP Attenuates β‐Adrenergic Receptor Mediated Cardiac Fibrosis depending on NOX2/ROS/p38 Pathway
CONCLUSIONS AND IMPLICATIONSIDHP attenuates cardiac fibrosis induced by isoproterenol through NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis.
Source: British Journal of Pharmacology - March 13, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed issue Source Type: research
