Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.

Conclusion: VPA could inhibit Hdac1/2/3, Vangl2/Scrib, or total Hdac activity both in vitro and in vivo and Hdac3 might participate in the process of VPA-induced cardiac developmental anomalies.
PMID: 30127218 [PubMed - in process]

Source: Chinese Medical Journal - August 23, 2018 Category: General Medicine Authors: Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C Tags: Chin Med J (Engl) Source Type: research