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Condition: Heart Disease

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Total 126 results found since Jan 2013.

TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload
Conclusion: TMEM16A contributes insignificantly in myocardium remodeling during pressure-overload. TMEM16A is a positive regulator of migration and angiogenesis under normal condition or simulated stress. TMEM16A may become a new target for upregulation of angiogenesis in ischemic disorders like ischemic heart disease.
Source: Frontiers in Physiology - May 31, 2022 Category: Physiology Source Type: research

LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide
AbstractMyocardial fibrosis confers an almost threefold mortality risk in heart disease. There are no prognostic therapies and novel therapeutic targets are needed. Many thousands of unannotated small open reading frames (smORFs) have been identified across the genome with potential to produce micropeptides (< 100 amino acids). We sought to investigate the role of smORFs in myocardial fibroblast activation.Analysis of human cardiac atrial fibroblasts (HCFs) stimulated with profibrotic TGF β1 using RNA sequencing (RNA-Seq) and ribosome profiling (Ribo-Seq) identified long intergenic non-coding RNA LINC01013 as TGFβ1...
Source: Journal of Cardiovascular Translational Research - June 27, 2022 Category: Cardiology Source Type: research

MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1)
Toxicology. 2022 Jul 2:153252. doi: 10.1016/j.tox.2022.153252. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common heart disease in patients with diabetes mellitus (DM), and is sometimes its main cause of death. Among all the causes of DCM, myocardial cell death is considered to be the most basic pathological change. Furthermore, studies have shown that pyroptosis, the pro-inflammatory programmed cell death, contributes to the progress of DCM. MicroRNAs (miRNAs) also have been proved to take part in the formation of DCM. However, it is not clear whether and how miRNAs regulate myocardial cell pyroptosis...
Source: Toxicology - July 6, 2022 Category: Toxicology Authors: Simin Zhao Yao Tan Jianning Qin Haiqiang Xu Lingyun Liu Hengquan Wan Chi Zhang Wenjing Fan Shunlin Qu Source Type: research

GSE207658 Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Contributors : Georg Vogler ; Alexandre R ColasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identified. Postulating that impaired cardiomyocyte proliferation as a likely important contributing mechanism to HLHS pathogenesis, and we conducted a genome-wide siRNA screen to identify genes affecting proliferation of human iPSC-derived cardiomyocy...
Source: GEO: Gene Expression Omnibus - July 14, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Penehyclidine hydrochloride protects Rat cardiomyocytes from ischemia-reperfusion injury by platelet-derived growth factor-B
CONCLUSION: PHC pretreatment can protect cardiomyocytes from the decrease of cell activity and the increase of apoptosis caused by reperfusion through up-regulating PDGF-B to activate PI3K pathway. Our study indicates that PHC is a potential drug to protect cells from reperfusion injury and PDGF-B is a potential target for preventing MI-R injury.PMID:35838232 | DOI:10.2174/1386207325666220715090505
Source: Combinatorial Chemistry and High Throughput Screening - July 15, 2022 Category: Chemistry Authors: Yan Lu Congna Zi Liang Zhang Boqun Cui Ling Li Jun Ma Source Type: research

HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R
Cell Stress Chaperones. 2022 Jul 16. doi: 10.1007/s12192-022-01290-0. Online ahead of print.ABSTRACTHypoxia/reoxygenation (H/R) is used as an in vivo model of ischemia/reperfusion injury, and myocardial ischemia can lead to heart disease. Calcium overload is an important factor in myocardial ischemia-reperfusion injury and can lead to apoptosis of myocardial cells. Therefore, it is of great clinical importance to find ways to regulate calcium overload and reduce apoptosis of myocardial cells, and thus alleviate myocardial ischemia-reperfusion injury. There is evidence that heat shock protein 70 (HSP70) has a protective eff...
Source: Cell Stress and Chaperones - July 16, 2022 Category: Cytology Authors: TianYu Liu Zhaodong Juan Bin Xia GuanHua Ren Zhen Xi JunWen Hao ZhongDong Sun Source Type: research

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