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Condition: Diabetes Type 1

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Total 127 results found since Jan 2013.

Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats.
CONCLUSIONS Silencing of TRB3 has a significant ameliorative effect on diabetic nephropathy in rats. PMID: 28600485 [PubMed - in process]
Source: Medical Science Monitor - June 11, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation.
In conclusion, our present study demonstrates that endothelial mTORC1 deletion protects against hindlimb ischemic injury in diabetic mice possibly via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation. Therapeutics targeting mTORC1 may therefore represents a promising strategy to rescue limb ischemia in diabetes mellitus. PMID: 28473248 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 1, 2017 Category: Biology Authors: Fan W, Han D, Sun Z, Ma S, Gao L, Chen J, Li X, Li X, Fan M, Li C, Hu D, Wang Y, Cao F Tags: Free Radic Biol Med Source Type: research

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 11, 2017 Category: Endocrinology Source Type: research

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

Upregulated serum sclerostin level in the T2DM patients with femur fracture inhibits the expression of bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling.
CONCLUSIONS: Our study demonstrated that the upregulated serum sclerostin level in the T2DM patients with fracture inhibited the expression of the bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling. It suggests that sclerostin might be an effective target for T2DM-associated bone fracture and delayed fracture healing. PMID: 28239825 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 1, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22 RESEARCH ARTICLE
ABSTRACT Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus. Here, we provide structural and functional evidence for aberrant pre-mRNA splicing in a chronic type 1 model of experimental diabetic polyneuropathy (DPN). Cajal bodies (CBs), unique nuclear substructures involved in RNA splicing, increased in number in diabetic sensory neurons, but their expected colocalization with survival motor neuron (SMN) proteins was reduced – a mislocalization described in motor neurons of spinal muscular atro...
Source: DMM Disease Models and Mechanisms - February 28, 2017 Category: Biomedical Science Authors: Kobayashi, M., Chandrasekhar, A., Cheng, C., Martinez, J. A., Ng, H., de la Hoz, C., Zochodne, D. W. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research

G protein coupled kinase-2 upregulation causes κ-opioid receptor desensitization in diabetic heart.
In conclusion, these data for the first time demonstrate that GRK2 upregulation is largely responsible for cardiac KOR desensitization in diabetic individuals, which provides novel insights for the management of I/R injury in patients with diabetes. PMID: 27865836 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - November 15, 2016 Category: Biochemistry Authors: Chen X, Zhao S, Xia Y, Xiong Z, Li Y, Tao L, Zhang F, Wang X Tags: Biochem Biophys Res Commun Source Type: research

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3 β-PP2Ac-NF-κB Signaling Axis
by Xiao-min Ren, Guang-feng Zuo, Wen Wu, Jie Luo, Peng Ye, Shao-liang Chen, Zuo-ying Hu Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain unclear. Therefore, our study investigated the role of the glycogen s ynthase kinase (GSK)-3β-protein phosphatase 2A(PP2A)-NF-κB signaling pathway in the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in high glucose (HG) and in DCM. Our results showed that, in HG-cultured card...
Source: PLoS One - November 15, 2016 Category: Biomedical Science Authors: Xiao-min Ren Source Type: research

Interferon-alpha inhibits adipogenesis via regulation of JAK/STAT1 signaling
Conclusion We suggest that IFN-α inhibits adipocyte differentiation during the early stage of adipogenesis by regulating the expression of PPARγ and C/EBPα as well as the cell cycle through JAK/STAT1 signaling pathways. General significance Our study provides new insights into possible mechanisms of the anti-adipogenetic effects of IFN-α.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - August 30, 2016 Category: Biochemistry Source Type: research

Specific MAPK inhibitors prevent hyperglycemia-induced renal diseases in type 1 diabetic mouse model.
Abstract Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse model, and clarify the crosstalk among MAPK signaling. Type 1 diabetic mouse model was established in male C57BL/6 J mice, and treated with or without 10 mg/kg MAPK blockers, including ERK inhibitor PD98059, p38 inhibitor SB203850, and JNK inhibitor SP600125 for four weeks. Hyperglycemia i...
Source: Molecular and Cellular Biochemistry - July 6, 2016 Category: Biochemistry Authors: Hong Z, Hong Z, Wu D, Nie H Tags: Mol Cell Biochem Source Type: research

Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming
In this study, we examined mechanisms of pancreatic cold preservation and rewarming-induced injury by interrogating the proapoptotic gene BBC3/Bbc3, also known as Puma (p53 upregulated modulator of apoptosis), using three experimental models: 1) bioluminescence imaging of isolated luciferase-transgenic ("Firefly") Lewis rat islets, 2) cold preservation of en bloc-harvested pancreata from Bbc3-knockout (KO) mice, and 3) cold preservation and rewarming of human pancreata and isolated islets. Cold preservation-mediated islet injury occurred during rewarming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siRNA into i...
Source: AJP: Endocrinology and Metabolism - June 13, 2016 Category: Endocrinology Authors: Omori, K., Kobayashi, E., Komatsu, H., Rawson, J., Agrawal, G., Parimi, M., Oancea, A. R., Valiente, L., Ferreri, K., Al-Abdullah, I. H., Kandeel, F., Takahashi, M., Mullen, Y. Tags: Call for Papers Source Type: research

Involvement of a pro-apoptotic gene BBC3 in islet injury mediated by cold preservation and re-warming.
In this study, we examined mechanisms of pancreatic cold preservation and re-warming-induced injury by interrogating a pro-apoptotic gene BBC3/Bbc3, also known as Puma (p53 upregulated modulator of apoptosis), using three experimental models: 1) bioluminescence imaging of isolated luciferase-transgenic ("Firefly") Lewis rat islets, 2) cold preservation of en bloc-harvested pancreata from Bbc3 knockout (KO) mice, and 3) cold preservation and re-warming of human pancreata and isolated islets. Cold preservation-mediated islet injury occurred during re-warming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siRNA into...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 25, 2016 Category: Physiology Authors: Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y Tags: Am J Physiol Endocrinol Metab Source Type: research

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice
Conclusions/interpretation Epigenetic modification of DNA by methylation in response to immunological stressors may be a mechanism that affects insulin gene expression during the progression of type 1 diabetes.
Source: Diabetologia - April 9, 2016 Category: Endocrinology Source Type: research

Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation Vascular Medicine
Conclusions Our results show that hyperglycemia suppresses macrophage activation and aneurysmal degeneration through the activation of Nr1h2. Although further validation of the underlying pathway is necessary, targeting Nr1h2 is a potential therapeutic approach to treating aneurysm.
Source: JAHA:Journal of the American Heart Association - March 27, 2016 Category: Cardiology Authors: Tanaka, T., Takei, Y., Yamanouchi, D. Tags: Aneurysm Vascular Medicine Source Type: research

Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina.
Authors: Jiang Y, Zhang Q, Steinle JJ Abstract Vascular endothelial cell growth factor (VEGF) is increased in diabetic macular edema. Compound 49b, a novel β-adrenergic receptor agonist, is protective in a type 1 diabetic rat model. We questioned whether Compound 49b could decrease VEGF levels, suggesting that Compound 49b may be effective against edema. Two-month diabetic rats received topical Compound 49b for 7 days only and/or insulin-like growth factor binding protein 3 (IGFBP-3) siRNA. We also measured endothelial nitric oxide synthase (eNOS) and protein kinase C (PKC)ζ and PKCδ phosphorylation. Retinal end...
Source: Growth Factors - February 18, 2016 Category: Research Tags: Growth Factors Source Type: research