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Condition: Diabetes Type 1
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Total 127 results found since Jan 2013.
GSE85496 Microarray mRNA expression profiling in Stat5b knockdown pancreatic beta cell line
Contributors : Malini Laloraya ; Annu JosephSeries Type : Expression profiling by arrayOrganism : Mus musculusStat5b gene is located at IDD4 type 1 diabetes susceptibility interval, and is mutated in NOD mice. This mutation has been linked to diabetes with strong association with autoimmune aetiology. We have treated MIN6 pancreatic beta cell line with Stat5b siRNA and analyzed the differential expression profile in control siRNA treated versus Stat5b siRNA treated cells in an effort to understand the role of Stat5b in diabetes.
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GDF11 promotes wound healing in diabetic mice via stimulating HIF-1 ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization
Acta Pharmacol Sin. 2022 Nov 8. doi: 10.1038/s41401-022-01013-2. Online ahead of print.ABSTRACTNon-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db (T2DM) mice. In the present study, we elucidated the cellular and molecular mechanisms underlying the action of GDF11 on healing of small skin wound. Single round-shape full-thickness wound of 5-mm diameter with muscle and bone exposed was made o...
Source: Acta Pharmacologica Sinica - November 8, 2022 Category: Drugs & Pharmacology Authors: Ying Zhang Yi-Yuan Zhang Zhen-Wei Pan Qing-Qi Li Li-Hua Sun Xin Li Man-Yu Gong Xue-Wen Yang Yan-Ying Wang Hao-Dong Li Li-Na Xuan Ying-Chun Shao Meng-Meng Li Ming-Yu Zhang Qi Yu Zhange Li Xiao-Fang Zhang Dong-Hua Liu Yan-Meng Zhu Zhong-Yue Tan Yuan-Yuan Zh Source Type: research
Blockage of MyD88 in cardiomyocytes alleviates cardiac inflammation and cardiomyopathy in experimental diabetic mice
In this study, we first found that MyD88 expression was increased in cardiomyocytes of diabetic mouse hearts. In cultured cardiomyocytes, MyD88 inhibition either by siRNA or by small-molecular inhibitor LM8 markedly blocked TLR4-MyD88 complex formation, reduced pro-inflammatory mitogen-activated protein kinases/nuclear factor-κB (MAPKs/NF-κB) cascade activation and decreased pro-inflammatory cytokine expression under high glucose condition. Moreover, pharmacologic inhibition of MyD88 by LM8 showed significantly anti-inflammatory, anti-hypertrophic and anti-fibrotic effects in the hearts of both type 1 and type 2 diabetic...
Source: Biochemical Pharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Wu Luo Gaojun Wu Xiaojun Chen Qiuyan Zhang Chunpeng Zou Jun Wang Jun Liu Nipon Chattipakorn Yi Wang Guang Liang Source Type: research
TNFAIP3 is anti-inflammatory in the retinal vasculature
CONCLUSIONS: TNFAIP3 serves as an anti-inflammatory factor in the retinal vasculature. Epac1 regulates TNFAIP3. TNFAIP3 may offer a new mechanism for regulating inflammation and permeability in the retinal vasculature.PMID:36034737 | PMC:PMC9352365
Source: Molecular Vision - August 29, 2022 Category: Molecular Biology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
