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Condition: Diabetes Type 1
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Total 127 results found since Jan 2013.
Repurposed major urinary protein pheromones and adult sensory neurons: Roles in neuron plasticity and experimental diabetes
Am J Physiol Endocrinol Metab. 2022 May 30. doi: 10.1152/ajpendo.00001.2022. Online ahead of print.ABSTRACTMajor urinary proteins (MUPs), members of the broader lipocalin protein family, are classified as pheromones that are excreted in male rodent urine to define conspecific territoriality. In screening for differentially regulated mRNA transcripts in a mouse model of type 1 experimental diabetes mellitus (DM), we identified an unexpected upregulation of several closely related MUP transcripts within diabetic sensory dorsal root ganglia (DRGs). Both sexes expressed overall MUP protein content as identified by an antibody ...
Source: Am J Physiol Endocri... - May 31, 2022 Category: Endocrinology Authors: Trevor Poitras Vandana Singh Ramanaguru Piragasam Xiuling Wang Atef Mahmoud Mannaa Ambika Chandrasekhar Jose Martinez Richard Fahlman Douglas W Zochodne Source Type: research
Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
J Biomed Res. 2022 May 15:1-14. doi: 10.7555/JBR.36.20210198. Online ahead of print.ABSTRACTThe present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Furthermore, GA obviously reduced the...
Source: Cell Research - May 17, 2022 Category: Cytology Authors: Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han Source Type: research
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
CONCLUSIONS: Urine cathepsin D is associated with rapid eGFR decline in T1D and reflects kidney tubulointerstitial injury.PMID:35377940 | DOI:10.2337/dc21-2204
Source: Cancer Control - April 4, 2022 Category: Cancer & Oncology Authors: Christine P Limonte Erkka Valo Viktor Drel Loki Natarajan Manjula Darshi Carol Forsblom Clark M Henderson Andrew N Hoofnagle Wenjun Ju Matthias Kretzler Daniel Montemayor Viji Nair Robert G Nelson John F O'Toole Robert D Toto Sylvia E Rosas John Ruzinski Source Type: research
Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T PTPN22 Variant for Immunotherapy in Endocrine Autoimmunity
The C1858T variant of the protein tyrosine phosphatase N22 (PTPN22) gene is associated with pathophysiological phenotypes in several autoimmune conditions, namely, Type 1 diabetes and autoimmune thyroiditis. The R620W variant protein, encoded by C1858T, leads to a gain of function mutation with paradoxical reduced T cell activation. We previously exploited a novel personalized immunotherapeutic approach based on siRNA delivered by liposomes (lipoplexes, LiposiRNA) that selectively inhibit variant allele expression. In this manuscript, we functionalize lipoplexes carrying siRNA for variant C1858T with a high affinity ligand...
Source: Frontiers in Immunology - March 9, 2022 Category: Allergy & Immunology Source Type: research
Transforming growth factor- β1/Thrombospondin-1/CD47 axis mediates dysfunction in CD34 < sup > + < /sup > cells derived from diabetic older adults
This study tested the hypothesis that transforming growth factor- β1 (TGF-β1) is upregulated in diabetic CD34+ cells and impairs NO generation via thrombospondin-1 (TSP-1)/CD47/NO pathway. CD34+ cells from nondiabetic (ND) (n=58) or diabetic older adults (DB) (both type 1 and type 2) (n=62) were isolated from peripheral blood. TGF-β1 was silenced by using an antisense delivered as phosphorodiamidate morpholino oligomer (PMO-TGF-β1). Migration and proliferation in response to stromal-derived factor-1α (SDF-1α) were evaluated. NO generation and eNOS phosphorylation were determined by flow cytometry. CD34+ cells from ol...
Source: European Journal of Pharmacology - February 26, 2022 Category: Drugs & Pharmacology Authors: Jesmin Jahan Ildamaris Monte de Oca Brian Meissner Shrinidh Joshi Ahmad Maghrabi Julio Quiroz-Olvera Chrisitne Lopez-Yang Stephen H Bartelmez Charles Garcia Yagna P Jarajapu Source Type: research
Enhanced Store-Operated Ca2+ Signal of Small Intestinal Smooth Muscle Cells Accelerates Small Bowel Transit Speed in Type 1 Diabetic Mouse
Conclusion: We concluded that the increased SOCE caused by excessive STIM1 and Orai1 expression and decreased Orai1-BKCa interaction augmented small intestinal smooth muscle contraction and accelerated small bowel transit speed in diabetic mice. This finding demonstrates a pathological role for SOCE in diabetic enteropathy and provides a potential therapeutic target for diabetic enteropathy.
Source: Frontiers in Physiology - October 20, 2021 Category: Physiology Source Type: research
NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes
The rs540467 SNP in the NDUFB6 gene, encoding a mitochondrial complex I subunit, has been shown to modulate adaptations to exercise training. Interaction effects with diabetes mellitus remain unclear. We assessed associations of habitual physical activity (PA) levels with metabolic variables and examined a possible modifying effect of the rs540467 SNP. Volunteers with type 2 (n=242), type 1 diabetes (n=250) or normal glucose tolerance (control; n=139) were studied at diagnosis and subgroups with type 1 (n=96) and type 2 diabetes (n=95) after 5 years. Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamps, o...
Source: Frontiers in Endocrinology - September 24, 2021 Category: Endocrinology Source Type: research
