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Condition: Chronic Obstructive Pulmonary

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Total 173 results found since Jan 2013.

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.
Abstract Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase rele...
Source: International Journal of Molecular Medicine - December 5, 2017 Category: Molecular Biology Authors: Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL Tags: Int J Mol Med Source Type: research

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism.
Abstract Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation. We investigated the effect of IL-22 on the expression in airway epithelial ce...
Source: Biochemical and Biophysical Research communications - November 30, 2017 Category: Biochemistry Authors: Seki N, Kan-O K, Matsumoto K, Fukuyama S, Hamano S, Tonai K, Ota K, Inoue H, Nakanishi Y Tags: Biochem Biophys Res Commun Source Type: research

HMGB1 mediates Aspergillus fumigatus-induced inflammatory response in alveolar macrophages of COPD mice via activating MyD88/NF- κB and syk/PI3K signalings.
In conclusion, HMGB1 is responsible for A. fumigatus-induced inflammatory response in COPD alveolar macrophage via Dectin-1 and TLR2/4 receptor through activating MyD88/NF-κB and syk/PI3K signalings. PMID: 29078091 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - October 24, 2017 Category: Allergy & Immunology Authors: Zhang P, Xin X, Fang L, Jiang H, Xu X, Su X, Shi Y Tags: Int Immunopharmacol Source Type: research

IL-1 β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma.
IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma. Immunol Lett. 2017 Oct 12;192:20-26 Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Abstract The manifest and important feature in respiratory diseases, including asthma and COPD (chronic obstructive pulmonary disease), is the increased numbers and hypersecretion of goblet cells and overexpression of mucins, especially Muc5ac. Many proinflammatory cytokines play important roles in goblet cell metaplasia and overproduction of Muc5ac. However, the effect of IL-1β on Muc5ac expression in asthma remains unknown. Here, we detected ...
Source: Immunology Letters - October 12, 2017 Category: Allergy & Immunology Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Tags: Immunol Lett Source Type: research

Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease
Conclusion: Overexpression of TRPC1 in COPD promoted EMT process and TRPC1 may be a new and interesting focus for COPD new treatment in the future.
Source: Medicine - October 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Anti-inflammatory effect of anti-tnf- α cationic phosphorous dendrimers nanocomplexes administered intranasally in a murine acute lung injury model.
ANTI-INFLAMMATORY EFFECT OF ANTI-TNF-α CATIONIC PHOSPHOROUS DENDRIMERS NANOCOMPLEXES ADMINISTERED INTRANASALLY IN A MURINE ACUTE LUNG INJURY MODEL. Biomacromolecules. 2017 Jun 22;: Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Abstract Inflammation is an essential component of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD) or acute lung injury. Our purpose was to design efficient carriers for lung delivery of small interfering RNA (siRNA) targeting tumor necrosis factor (TNF-α) in an...
Source: Biomacromolecules - June 22, 2017 Category: Biochemistry Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Tags: Biomacromolecules Source Type: research

Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by unresolved neutrophilic airway inflammation, and is caused by chronic exposure to toxic gases, such as cigarette smoke (CS), in genetically susceptible individuals. Recent data indicate a role for Damage Associated Molecular Patterns (DAMPs) in COPD. Here, we investigated the genetics of CS-induced DAMP release in 28 inbred mouse strains. Subsequently, in lung tissue from a subset of strains the expression of the identified candidate genes was analyzed. We tested whether siRNA-dependent knockdown of candidate genes altered the susceptibility...
Source: Am J Physiol Lung Ce... - June 8, 2017 Category: Respiratory Medicine Authors: Pouwels SD, Faiz A, den Boef LE, Gras R, van den Berge M, Boezen HM, Korstanje R, Ten Hacken NHT, van Oosterhout AJM, Heijink IH, Nawijn MC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

p300 and C/EBP β-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells
In this study, we aimed to investigate the roles of p300 and C/EBPβ-reliant IKKβ expression in thrombin-induced IL-8/CXCL8 expression. Thrombin-induced increases in IL-8/CXCL8-luciferase activity and IL-8/CXCL8 release were inhibited by p300 small interfering (siRNA). Thrombin-caused histone H3 acetylation was attenuated by p300 siRNA. Stimulation of cells with thrombin for 12h resulted in increases in IKKβ expression and phosphorylation in human lung epithelial cells. However, thrombin did not affect p65 expression. Moreover, 12h of thrombin stimulation produced increases in IKKβ expression and phosphorylation, and IÎ...
Source: Pharmacological Research - April 26, 2017 Category: Drugs & Pharmacology Source Type: research

Klotho Regulates Cigarette Smoke-Induced Autophagy: Implication in Pathogenesis of COPD
ConclusionsThese data suggest that Klotho plays a critical role in the regulation of CS-induced autophagy and have important implications in understanding the mechanisms of CS-induced cell death and senescence.
Source: Lung - March 28, 2017 Category: Respiratory Medicine Source Type: research

Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells
In conclusion, these data suggest that dexamethasone increases MKP-1 expression and th is results in the suppression of p38 MAPK signaling leading to the inhibition of cytokine production in human bronchial epithelial cells. These results point to the role of MKP-1 as an important factor in the therapeutic effects of glucocorticoids in the treatment of inflammatory lung diseases.
Source: Inflammation Research - March 14, 2017 Category: Research Source Type: research

Molecules, Vol. 22, Pages 139: Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases
Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic pulmonary fibrosis (IPF). The advantage of direct accessibility for oligonucleotide molecules to the lung target sites, bypassing systemic administration, makes this therapeutic approach promising with minimized potential systemic side effects. Asthma, COPD, and IPF are common chronic respiratory diseases, characterized by persistent airway inflammation and dysregulated tissue re...
Source: Molecules - January 16, 2017 Category: Chemistry Authors: Wupeng Liao Jinrui Dong Hong Peh Lay Tan Kah Lim Li Li Wai-Shiu Wong Tags: Review Source Type: research

NDP52 inhibition rescues cigarette smoke mediated impairment of autophagy in macrophages
Conclusion: Cigarette smoke increases expression of autophagic markers and impairs autophagic flux in macrophages and may be the cause of the increased NDP52 expression observed in COPD patient lungs. Knockdown of NDP52 restored the flux in CSE exposed macrophages and resulted in a reduction of autophagic makers to basal levels.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Kono, Y., Mercado, N., Ito, K., Barnes, P., Colley, T. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Targeting ASK1 in preventing airway smooth muscle growth: Implications for airway remodeling in COPD
In this study we aimed to determine the effects of ASK1 inhibition on ASM growth and pro-mitogenic signaling. We found expression of ASK1 on human lung tissue and primary human ASM cells. Pre-treatment of human ASM cells with potent and orally available ASK1 inhibitor, TCASK10 resulted in a dose-dependent reduction in mitogen (FBS, PDGF and EGF)-induced ASM growth as measured by CyQuant assay. Furthermore, the effectiveness of this pharmacological inhibition was established and replicated in gene silencing experiments where ASK1 siRNA inhibited mitogen-induced human ASM cell growth. Immunoblotting revealed that the anti-mi...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Xenaki, D., Deshpande, D., Oliver, B., Sharma, P. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

MUC1-CT mediates corticosteroid responses in COPD
Conclusions: MUC1-CT mediates the anti-inflammatory properties of corticosteroids and the lack of its expression in COPD increases resistance to corticosteroids.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Diaz, L., Milara, J., Morcillo, E., Serrano, A., Guijarro, R., Sanz, C., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

LATE-BREAKING ABSTRACT: MUC1 downregulation induces corticosteroid resistance in asthma's in vitro and in vivo models
Conclusion: MUC1 downregulation may lack the anti-inflammatory effects of corticosteroids in Asthma.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Morell, A., Bel, E., Milara, J., Morcillo, E., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research