Filtered By:
Condition: Chronic Obstructive Pulmonary
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 173 results found since Jan 2013.
Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both caspase-1/IL-1 β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells
In this study, biofuel PM2.5 extracted from wood smoke (WSPM2.5) was used according to our previous publication. A 16-HBE cell line was used as the cell model. Results showed that: Firstly, WSPM2.5 induced significant pyroptosis in 16-HBE cells, reflected by the typical changes including elevated release of lactate dehydrogenase release (LDH) and activated activity and expression of Caspase-1/IL-1β/IL-18 signaling pathway. Then, specific inhibitors for both Caspases (Z-VAD-FMK) and Caspase-1 (VX-765), as well as specific siRNA knockdown of IL-1β all effectively attenuated the WSPM2.5-induced upregulation of downstream in...
Source: Chemosphere - July 19, 2022 Category: Chemistry Authors: Xin Fu Wei Hong Shuyi Li Zhi Chen Wenqu Zhou Jianwei Dai Xiaoliang Deng Hongbin Zhou Bing Li Pixin Ran Source Type: research
PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy
Toxicology. 2022 Jul 1:153251. doi: 10.1016/j.tox.2022.153251. Online ahead of print.ABSTRACTCigarette smoke (CS) mediates inflammation and epithelial-mesenchymal transition (EMT) in bronchial epithelial cells, contributing to airway remodeling in chronic obstructive pulmonary disease (COPD). Cross-talk between metabolic pathways and cell signaling has emerged as an important focus of research in the field of inflammation. Here, we established in vitro and in vivo models of CS-induced COPD to elucidate the role of pyruvate kinase M2 (PKM2), a glycolytic enzyme, in CS-induced airway remodeling. Exposure to CS significantly ...
Source: Toxicology - July 5, 2022 Category: Toxicology Authors: Diandian Li Cheng Shen Lian Liu Jun Hu Jiangyue Qin Luqi Dai Lijuan Gao Mengxin Cheng Dingran Wang Rong Bao Bo Wang Source Type: research
Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease
Biomed Pharmacother. 2022 Jun 7;152:113244. doi: 10.1016/j.biopha.2022.113244. Online ahead of print.ABSTRACTAirway mucus hypersecretion is a vital pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients in which airflow limitation result, and it is key to strategizing in the management of COPD. To investigate the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated, human organoid model of trachea was established and all trea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2022 Category: Drugs & Pharmacology Authors: Yuan-Yuan Wei Da-Wei Zhang Jing-Jing Ye Qing-Xia Lan Shuang Ji Li Sun Fang Li Guang-He Fei Source Type: research
The role of retinoid-related orphan receptor- α in cigarette smoke-induced autophagic response
CONCLUSIONS: Our findings suggest that RORα promotes autophagy and contributes to COPD pathogenesis via regulation of the RORα-p53-DRAM pathway.PMID:35509068 | DOI:10.1186/s12931-022-02034-5
Source: Cell Research - May 5, 2022 Category: Cytology Authors: Hak-Su Kim Chang Hyeok An Danielle Teller Su-Jin Moon Gi Won Hwang Jin Woo Song Source Type: research
Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis
CONCLUSION: This research suggested that H2S alleviated PM-induced emphysema and airway inflammation via restoring redox balance and inhibiting ferroptosis through regulating Nrf2-PPAR-ferritinophagy signaling pathway.PMID:35490984 | DOI:10.1016/j.freeradbiomed.2022.04.014
Source: Free Radical Biology and Medicine - May 1, 2022 Category: Biology Authors: Ying Wang Sha Liao Zihan Pan Simin Jiang Jing Fan Siwang Yu Lixiang Xue Jianling Yang Shaohua Ma Tong Liu Jing Zhang Yahong Chen Source Type: research
Involvement of < em > NEAT1 < /em > /PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM < sub > 2.5 < /sub >
CONCLUSIONS: Our results suggest that CS and PM2.5 exposure induce mitochondrial dysfunction, and the NEAT1/PINK1 pathway plays a critical role in the occurrence and development of COPD by regulating mitophagy.PMID:35433942 | PMC:PMC9011272 | DOI:10.21037/atm-22-542
Source: Cancer Control - April 18, 2022 Category: Cancer & Oncology Authors: Qi Lin Chao-Feng Zhang Jin-Ling Guo Jian-Lin Su Zhen-Kun Guo Huang-Yuan Li Source Type: research
