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Condition: Chronic Obstructive Pulmonary
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Total 173 results found since Jan 2013.
Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats
CONCLUSION: These results suggest that AITC improves COPD by promoting RCT process and reducing inflammatory response via activating LXR pathways.PMID:34802946 | DOI:10.1016/j.intimp.2021.108373
Source: International Immunopharmacology - November 22, 2021 Category: Allergy & Immunology Authors: Wen-Tao Zhu Chen-Hui Li Ting-Ting Dai Fu-Lin Tao Meng-Wen Wang Chong-Yang Wang Zhi-Li Han Nian-Xia Sun Ya-Nan Zhao Dian-Lei Wang Source Type: research
Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis
In conclusion, our study demonstrates that CSE-induced ROS production may increase the expression of STIM1 in macrophages, which further promotes the release of IL-8 by regulating Ca2+ entry. These data suggest that STIM1 may play a crucial role in CSE-induced ROS production and inflammation, and participate in the pathogenesis of COPD.
Source: Frontiers in Physiology - October 8, 2021 Category: Physiology Source Type: research
LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE
Am J Physiol Lung Cell Mol Physiol. 2021 Aug 18. doi: 10.1152/ajplung.00138.2021. Online ahead of print.ABSTRACTThe receptor for advanced glycation end-products (RAGE) has been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, it is still unknown whether RAGE directly contributes to alveolar epithelial damage and abnormal repair responses. We hypothesize that RAGE activation not only induces lung tissue damage but also hampers alveolar epithelial repair responses. The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild...
Source: Am J Physiol Lung Ce... - August 18, 2021 Category: Respiratory Medicine Authors: Simon D Pouwels Laura Hesse Xinhui Wu Venkata Sita Rama Raju Allam Daan van Oldeniel Linsey J Bhiekharie Simon Phipps Brian G G Oliver Reinoud Gosens Maria Sukkar Irene H Heijink Source Type: research
Therapeutic Approaches Targeting Molecular Signaling Pathways Common to Diabetes and Lung Diseases and Cancer
Adv Drug Deliv Rev. 2021 Aug 7:113918. doi: 10.1016/j.addr.2021.113918. Online ahead of print.ABSTRACTDiabetes mellitus (DM), is the most common metabolic disease and is characterized by sustained hyperglycemia. Accumulating evidences supports a strong association between DM and numerous lung diseases including chronic obstructive pulmonary disease (COPD), fibrosis, and lung cancer (LC). The global incidence of DM-associated lung disorders is rising and several ongoing studies, including clinical trials, aim to elucidate the molecular mechanisms linking DM with lung disorders, in particular LC. Several potential mechanisms...
Source: Advanced Drug Delivery Reviews - August 10, 2021 Category: Drugs & Pharmacology Authors: Rajeswari Raguraman Akhil Srivastava Anupama Munshi Rajagopal Ramesh Source Type: research
