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Cancer: Esophagus Cancer

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Total 344 results found since Jan 2013.

GSE82108 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (III)
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - June 3, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
CONCLUSION: The PI3K/AKT pathway and HIF-1α are both involved in the process of glycolysis in esophageal cancer cells. PMID: 27239113 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 27, 2016 Category: Gastroenterology Authors: Zeng L, Zhou HY, Tang NN, Zhang WF, He GJ, Hao B, Feng YD, Zhu H Tags: World J Gastroenterol Source Type: research

The PI3K/AKT/c ‐MYC Axis Promotes the Acquisition of Cancer Stem‐Like Features in Esophageal Squamous Cell Carcinoma
In conclusion, we have described a novel intratumoral heterogeneity in ESCC. The identification of the PI3K/AKT/c‐MYC axis as a driver of CSC‐like features carries therapeutic implications. Stem Cells 2016;34:2040–2051 Oxidative stress induced by H2O2 promotes RU/RR conversion and the acquisition of CSC‐like properties. (A) Reactive oxygen species (ROS) induced by H2O2 (500 μM for 24 hours) was measured by flow cytometry. (B) H2O2‐induced RU/RR conversion in KYSE150‐RU cells, as indicated by the increase of GFP‐positive cells and luciferase activity. Representative flow cytometry data at Day 4 was shown in...
Source: Stem Cells - May 22, 2016 Category: Stem Cells Authors: Hai ‐Feng Zhang, Chengsheng Wu, Abdulraheem Alshareef, Nidhi Gupta, Qing Zhao, Xiu‐E Xu, Ji‐Wei Jiao, En‐Min Li, Li‐Yan Xu, Raymond Lai Tags: Cancer Stem Cells Source Type: research

Effects of siRNA-Mediated Knockdown of HDAC1 on the Biological Behavior of Esophageal Carcinoma Cell Lines.
CONCLUSIONS The siRNA-mediated HDAC1 knockdown significantly inhibited the proliferation, migration and invasion of TE-1 cells probably by regulating the expression of cell cycle- and EMT-related proteins. PMID: 27086779 [PubMed - in process]
Source: Medical Science Monitor - April 20, 2016 Category: Research Tags: Med Sci Monit Source Type: research

GSE77790 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines II
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Kpn{beta}1 as an Anticancer Target
This study aimed to identify novel small molecule inhibitors of Kpnβ1, and determine their anticancer activity. An in silico screen identified molecules that potentially bind Kpnβ1 and Inhibitor of Nuclear Import-43, INI-43 (3-(1H-benzimidazol-2-yl)-1-(3-dimethylaminopropyl)pyrrolo[5,4-b]quinoxalin-2-amine) was investigated further as it interfered with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes NFAT, NFB, AP-1, and NFY and inhibited the proliferation of cancer cells of different tissue origins. Minimum effect on the proliferation of noncancer cells was observed at the concentration of IN...
Source: Molecular Cancer Therapeutics - April 4, 2016 Category: Cancer & Oncology Authors: van der Watt, P. J., Chi, A., Stelma, T., Stowell, C., Strydom, E., Carden, S., Angus, L., Hadley, K., Lang, D., Wei, W., Birrer, M. J., Trent, J. O., Leaner, V. D. Tags: Small Molecule Therapeutics Source Type: research

The PI3K/AKT/c‐MYC axis promotes the acquisition of cancer stem‐like features in esophageal squamous cell carcinoma
In conclusion, we have described a novel intra‐tumoral heterogeneity in ESCC. The identification of the PI3K/AKT/c‐MYC axis as a driver of CSC‐like features carries therapeutic implications. This article is protected by copyright. All rights reserved. Oxidative stress induced by H2O2 promotes RU/RR conversion and the acquisition of CSC‐like properties. (A) Reactive oxygen species (ROS) induced by H2O2 (500μM for 24h) was measured by flow cytometry. (B) H2O2‐induced RU/RR conversion in KYSE150‐RU cells, as indicated by the increase of GFP‐positive cells and luciferase activity. Representative flow cytometry ...
Source: Stem Cells - March 31, 2016 Category: Stem Cells Authors: Hai‐Feng Zhang, Chengsheng Wu, Abdulraheem Alshareef, Nidhi Gupta, Qing Zhao, Xiu‐E Xu, Ji‐Wei Jiao, En‐Min Li, Li‐Yan Xu, Raymond Lai Tags: Cancer Stem Cells Source Type: research

Podoplanin-mediated TGF-β-induced epithelial-mesenchymal transition and its correlation with bHLH transcription factor DEC in TE-11 cells.
In this study, we investigated the correlation between podoplanin and EMT-related markers in esophageal squamous cell carcinoma (ESCC), and evaluated its linkage with the basic helix-loop-helix (bHLH) transcription factor differentiated embryonic chondrocyte (DEC) 1 and DEC2. Three ESCC cell lines and human squamous cell carcinoma A431 cells were subjected to western blot analyses for podoplanin and EMT markers, as well as the expression of DEC1 and DEC2. By RT-qPCR and western blotting, we found that TGF-β increased the expression of podoplanin and mensenchymal markers (e.g., N-cadherin and vimentin), while decreased th...
Source: International Journal of Oncology - March 17, 2016 Category: Cancer & Oncology Authors: Wu Y, Liu Q, Yan X, Kato Y, Tanaka M, Inokuchi S, Yoshizawa T, Morohashi S, Kijima H Tags: Int J Oncol Source Type: research

Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress
Conclusions: Overall, the results indicate that PTE is a potent anti-cancer pharmaceutical against human esophageal cancer, and the possible mechanism involves the activation of ERS signaling pathways.Cell Physiol Biochem 2016;38:1226-1244
Source: Cellular Physiology and Biochemistry - March 16, 2016 Category: Cytology Source Type: research

Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells.
CONCLUSION: Our findings highlight a critical role of ATF4-CHOP-DR5 axis-mediated extrinsic apoptosis in neddylation-targeted cancer therapy and support the clinical investigation of neddylation inhibitors (e.g. MLN4924) for the treatment of ESCC, a currently treatment-resistant disease with neddylation hyperactivation. PMID: 26983464 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - March 16, 2016 Category: Cancer & Oncology Authors: Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, Qi H, Yang M, Hoffman RM, Dong Z, Jia L Tags: Clin Cancer Res Source Type: research

B7-H3 expression associates with tumor invasion and patient's poor survival in human esophageal cancer.
Authors: Chen L, Chen J, Xu B, Wang Q, Zhou W, Zhang G, Sun J, Shi L, Pei H, Wu C, Jiang J Abstract B7-H3, a member from B7-family co-stimulatory ligands, plays an important role in adaptive immune responses. In addition, recent studies also demonstrated that B7-H3 could be highly expressed in various types of human cancers, and its expression level was significantly associated with cancer patients' clinicopathological parameters and postoperative prognoses. As of now, the exact role of B7-H3 expression in human esophageal cancer still remains elusive. In the present study, we characterized the B7-H3 expression in ...
Source: American Journal of Translational Research - February 19, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Long noncoding RNA, tissue differentiation ‐inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the major causes of cancer death worldwide, especially in Eastern Asia. Due to the poor prognosis, it is necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recently, studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Increasing evidence indicates that some lncRNAs are widely involved in the development and progression of ESCC, such as HOTAIR, SPRY4‐IT1 and POU3F3. An emerging lncRNA, tissue differentiation‐inducing nonprotein coding RNA (TINC...
Source: Diseases of the Esophagus - February 1, 2016 Category: Gastroenterology Authors: Y. Xu, M. Qiu, Y. Chen, J. Wang, W. Xia, Q. Mao, L. Yang, M. Li, F. Jiang, L. Xu, R. Yin Tags: Original Article Source Type: research

Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer.
CONCLUSIONS: The results suggest that BST-2 is involved in tumor progression and serves as an independent prognostic classifier for patients with GC. Because BST-2 is expressed on the cell membrane, BST-2 could be a therapeutic target for GC, CRC, and ESCC. PMID: 26832883 [PubMed - as supplied by publisher]
Source: Ann Oncol - February 1, 2016 Category: Cancer & Oncology Authors: Mukai S, Oue N, Oshima T, Mukai R, Tatsumoto Y, Sakamoto N, Sentani K, Tanabe K, Egi H, Hinoi T, Ohdan H, Yasui W Tags: Ann Surg Oncol Source Type: research

Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer
Conclusions The results suggest that BST-2 is involved in tumor progression and serves as an independent prognostic classifier for patients with GC. Because BST-2 is expressed on the cell membrane, BST-2 could be a therapeutic target for GC, CRC, and ESCC.
Source: Annals of Surgical Oncology - February 1, 2016 Category: Cancer & Oncology Source Type: research

RPA1 expression in esophageal carcinoma and its influence on radiosensitivity of esophageal carcinoma TE-1 cells.
CONCLUSION: The over-expression of RPA1 in esophageal carcinoma was related with progression and metastasis. Moreover, radiation induced the excessive expression RPA1 in TE-1 cells, and the radiosensitivity of TE-1R cells was less than that of TE-1 cells. Furthermore, inhibiting RPA1 expression could increase radiosensitivity of TE-1 cells. Overall, RPA1 could influence radiosensitivity and might be one important mechanism of radiation resistance in TE-1 cells. PMID: 26824734 [PubMed - as supplied by publisher]
Source: Panminerva Medica - January 31, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research