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Cancer: Esophagus Cancer

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Total 344 results found since Jan 2013.

PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKC α/NF-κB Pathway.
CONCLUSION: PLCE1 activated NF-κB signaling by up-regulating PKCα, which could promote invasion and migration of esophageal cancer cells. PMID: 30450849 [PubMed - in process]
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Li Y, Luan C Tags: Yonsei Med J Source Type: research

Proliferation Potential-Related Protein Promotes the Esophageal Cancer Cell Proliferation, Migration and Suppresses Apoptosis by Mediating the Expression of p53 and Interleukin-17
Conclusion: Our data suggest that PP-RP promotes esophageal cancer cell proliferation and migration, and suppresses apoptosis by mediating the expression of p53 and IL-17.Pathobiology
Source: Pathobiology - September 17, 2018 Category: Pathology Source Type: research

Long non-coding RNA FAL1 regulated cell proliferation through Akt pathway via targeting PDK1 in esophageal cancer cells.
CONCLUSIONS: FAL1 regulated cell proliferation through Akt pathway via targeting PDK1 in EC cells. These findings revealed that FAL1 exhibited oncogenic activity in EC, and inhibiting FAL1 might be useful for preventing the progression of EC. PMID: 30178844 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

GSE118966 Differentially expressed genes after siRNA transfection in human cancer cell lines TE8, 786-O, A498 and PANC1
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (siRNAs and miRNAs) in human cancer, several cell lines (esophagus cancer, renal cell carcinoma and pancreatic cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - August 24, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE118642 ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma
Contributors : Himiko Kodaira ; Hiroshi YokozakiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTumor-associated macrophages (TAMs) have important roles in the progression, angiogenesis and motility of various cancers. To study the effects of TAMs on the tumor microenvironment of ESCCs, we constructed an in vitro system for the differentiation of peripheral blood monocyte (PBMo)-derived macrophages into TAM-like PBMo-derived macrophages.We established a co-culture assay using a human ESCC cell line and TAM-like PBMo-derived macrophages and we performed a cDNA microarray analysis between monocultured and c...
Source: GEO: Gene Expression Omnibus - August 17, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

SLC1A5 Silencing Inhibits Esophageal Cancer Growth via Cell Cycle Arrest and Apoptosis
Conclusion: Our data indicate that SLC1A5 plays an important role in esophageal cancer bothin vivo andin vitro. The inhibition of esophageal cancer growth by targeting SLC1A5 could, therefore, be used as a preoperative therapy for esophageal cancer.Cell Physiol Biochem 2018;48:397 –397
Source: Cellular Physiology and Biochemistry - August 2, 2018 Category: Cytology Source Type: research

Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma.
In conclusion, the results of the present study suggested that the cytoplasm dominant expression of AQP1 is related to a poor prognosis in patients with ESCC, and that it activates tumor progression by affecting Death receptor signaling pathway. These results provide insights into the role of AQP1 as a mediator of and/or a biomarker for ESCC. PMID: 30042826 [PubMed]
Source: Oncotarget - July 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
Authors: Zhu X, Wang J, Li L, Deng L, Wang J, Liu L, Zeng R, Wang Q, Zheng Y Abstract Although an increasing number of findings have proven that glutathione peroxidase 3 (GPX3) is methylated and down-regulated in various cancers, the underlying mechanism of its occurrence in esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, we found that the methylation rate in advanced cancers was significantly higher than that in early stage cancers by a methylation-specific polymerase chain reaction. Furthermore, the proliferation and migration capacities of KYSE-510 cells were inhibited after up-r...
Source: American Journal of Translational Research - July 19, 2018 Category: Research Tags: Am J Transl Res Source Type: research

Long non-coding RNA DANCR promotes cell proliferation, migration, invasion and resistance to apoptosis in esophageal cancer.
Conclusions: According to our research, the expression of DANCR was up-regulated in human ESCC tissues, and the important role that DANCR played in ESCC cells was similar to an oncogene. Therefore, silencing of lncRNA DANCR could have potentially beneficial effects on the prognostic and therapy for ESCC in the future. PMID: 29997918 [PubMed]
Source: Journal of Thoracic Disease - July 14, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Co-targeting PLK1 and mTOR induces synergistic inhibitory effects against esophageal squamous cell carcinoma
In this study, we found that suppression of PLK1 by specific siRNA or inhibitor attenuated mTOR activity in ESCC cells. Phosphorylated S6, a downstream effector of mTOR signaling, was significantly correlated with overexpression of PLK1 in a subset of ESCC. These data suggest that PLK1 activates mTOR signaling in vitro and in vivo. More importantly, the mTOR inhibitor rapamycin synergized with PLK1 inhibitor BI 2536 to inhibit ESCC cell proliferation in culture and in mice. Notably, combined treatment with BI 2536 and rapamycin produced more potent inhibitory effects on the activation of S6 and AKT than either alone. Furth...
Source: Journal of Molecular Medicine - June 29, 2018 Category: Molecular Biology Source Type: research

Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma.
Conclusions: The results of the present study suggest that reductions in AE2 in ESCC enhance cellular movement by activating MMP signaling pathways and are related to a poor prognosis in patients with ESCC. Methods: In human ESCC cell lines, knockdown experiments were conducted using AE2 siRNA, and the effects on cellular movement and survival were analyzed. The gene expression profiles of cells were examined using a microarray analysis. An immunohistochemical analysis was performed on 61 primary tumor samples obtained from ESCC patients who underwent esophagectomy. PMID: 29899837 [PubMed]
Source: Oncotarget - June 15, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Osteopontin Expression Is Associated with the Poor Prognosis in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiotherapy.
Conclusions: Our results suggest that osteopontin may be a potential therapeutic target for patients with ESCC treated with preoperative chemoradiotherapy. PMID: 29854808 [PubMed - in process]
Source: Biomed Res - June 3, 2018 Category: Research Authors: Chiu TJ, Lu HI, Chen CH, Huang WT, Wang YM, Lin WC, Li SH Tags: Biomed Res Int Source Type: research

Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma.
Conclusions: The present results suggest that the very strong expression of CLIC1 enhances tumor survival, while its very weak expression promotes cellular movement. The present study provides an insight into the role of CLIC1 as a switch among tumor behaviors in ESCC. PMID: 29796185 [PubMed]
Source: Oncotarget - May 31, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Disturbed alternative splicing of FIR (PUF60) directed cyclin E overexpression in esophageal cancers.
In conclusion, elevated cyclin E expression was, in part, induced owing to potential FIR/FIRΔexon2-FBW7 interaction in ESCC. PMID: 29796163 [PubMed]
Source: Oncotarget - May 31, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF- β1.
RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-β1. Biochem Biophys Res Commun. 2018 May 28;: Authors: Wang DG, Li TM, Liu X Abstract Cervical cancer is the second commonest cancer among women in the worldwide, and the majority cause of death in various countries, highlighting the importance of investigating new therapeutic targets. Rh family, C glycoprotein (RHCG) belongs to the Rhesus (Rh) family and was first identified as Rh blood group antigens. It has been confirmed to function in cancer progression, including prostate cancer and ...
Source: Biochemical and Biophysical Research communications - May 28, 2018 Category: Biochemistry Authors: Wang DG, Li TM, Liu X Tags: Biochem Biophys Res Commun Source Type: research