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Cancer: Esophagus Cancer
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Total 344 results found since Jan 2013.
SLC7A9 as a Potential Biomarker for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma
CONCLUSIONS: SLC7A9 influences the malignant behavior of ESCC cells. Tumor SLC7A9 expression may serve as a novel biomarker for predicting lymph node metastasis and recurrence in ESCC patients.PMID:34773193 | DOI:10.1245/s10434-021-11001-1
Source: Ann Oncol - November 13, 2021 Category: Cancer & Oncology Authors: Hayato Baba Mitsuro Kanda Koichi Sawaki Shunsuke Nakamura Sei Ueda Dai Shimizu Masahiko Koike Yasuhiro Kodera Tsutomu Fujii Source Type: research
Relationship Between PTEN and Angiogenesis of Esophageal Squamous Cell Carcinoma and the Underlying Mechanism
Esophageal squamous cell carcinoma (ESCC) has high morbidity and mortality rates owing to its ability to infiltrate and metastasize. Microvessels formed in early-stage ESCC promote metastasis. Phosphatase and tensin homolog (PTEN) mediates macrophage polarization, but its effect and mechanism on early ESCC angiogenesis are unclear. To explore the molecular mechanism underlying early ESCC metastasis through blood vessels, we investigated the relationship between PTEN/phosphoinositide 3-kinase (PI3K)/p-AKT protein levels, number of infiltrated macrophages, and angiogenesis in ESCC and ESCC-adjacent normal esophageal mucosa t...
Source: Frontiers in Oncology - November 2, 2021 Category: Cancer & Oncology Source Type: research
Transgelin Inhibits the Malignant Progression of Esophageal Squamous Cell Carcinomas by Regulating Epithelial –Mesenchymal Transition
ConclusionTransgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT.
Source: Frontiers in Oncology - September 6, 2021 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 13, Pages 3165: The Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer
a
Mikihiro Fujiya
Previous investigations have indicated that RNA-binding proteins (RBPs) are key molecules for the development of organs, differentiation, cell growth and apoptosis in cancer cells as well as normal cells. A bioinformatics analysis based on the mRNA expression and a somatic mutational database revealed the association between aberrant expression/mutations of RBPs and cancer progression. However, this method failed to detect functional alterations in RBPs without changes in the expression, thus leading to false negatives. To identify major tumor-associated RBPs, we constructed an siRNA library based o...
Source: Cancers - June 24, 2021 Category: Cancer & Oncology Authors: Hiroaki Konishi Shin Kashima Takuma Goto Katsuyoshi Ando Aki Sakatani Hiroki Tanaka Nobuhiro Ueno Kentaro Moriichi Toshikatsu Okumura Mikihiro Fujiya Tags: Article Source Type: research
Trichostatin A promotes esophageal squamous cell carcinoma cell migration and EMT through BRD4/ERK1/2 ‐dependent pathway
ConclusionsOur data indicate the existence of at least two separable ERK1/2-dependent signaling pathways in TSA-mediated ESCC cell migration: an ERK1/2 –Slug branch and an ERK1/2-PAI-1 branch. Both branches of TSA-induced ESCC cell migration appear to favor the EMT process, while BRD4 is responsible for two separable ERK1/2-dependent signaling pathways in TSA-mediated ESCC cell migration.
Source: Cancer Medicine - June 23, 2021 Category: Cancer & Oncology Authors: Danhui Liu,
Yuzhen Liu,
Bo Qi,
Chengwei Gu,
Shuhua Huo,
Baosheng Zhao Tags: ORIGINAL RESEARCH Source Type: research
TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma
J Cell Mol Med. 2021 May 27. doi: 10.1111/jcmm.16652. Online ahead of print.ABSTRACTMounting data have shown that long non-coding RNAs (lncRNAs) widely participate in tumour initiation, development, progression and glycolysis in a variety of tumours. However, the clinical prognosis and molecular mechanisms of TMEM161B-AS1 in oesophageal squamous cell carcinoma (ESCC) remain still unknown. Here, TMEM161B-AS1 and HIF1AN were significantly lower in ESCC tissues than in normal samples, and their low expressions were both related to TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Functionally, TMEM161B-AS1...
Source: J Cell Mol Med - May 28, 2021 Category: Molecular Biology Authors: Zuxuan Shi Guanghui Li Zhen Li Junhao Liu Yu Tang Source Type: research
Novel small molecule inhibitor of Kpn β1 induces cell cycle arrest and apoptosis in cancer cells
This study investigated the effect of a novel small molecule, Inhibitor of Nuclear Import-60 (INI-60), on cancer cell biology, as well as nuclear import activities associated with Kpnβ1, and cancer progression in vivo using cervical and oesophageal cancer cell lines. INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis. Non-cancer cells were minimally affected by INI-60 at concentrations that inhibited cancer cells. INI-60 treatment altered the localisation of Kpnβ1 and its carg...
Source: Experimental Cell Research - May 21, 2021 Category: Cytology Authors: Aderonke Ajayi-Smith Pauline van der Watt Nonkululeko Mkwanazi Sarah Carden John O Trent Virna D Leaner Source Type: research
Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229
Accumulating evidence has demonstrated that circular RNAs (circRNAs) are involved in the pathogenesis of cancer, including that of esophageal squamous cell carcinoma (ESCC). The current study aimed to investigate the role of hsa_circ_0000700 in ESCC. hsa_circ_0000700, miR-1229, and related functional gene expression was measured by RT-qPCR. To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination. Cell Counting Kit-8 (CCK8), colony formation, EdU, flow cytometry, and Transwell assays were employed...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun Fang, Wen Hao Ji, Fang Zheng Wang, Tie Ming Xie, Lei Wang, Zhen Fu Fu, Zhun Wang, Feng Qin Yan, Qi Liang Shen, Zhi Min Ye Tags: Research Paper Source Type: research
Demethylated miR-216a Regulates High Mobility Group Box 3 Promoting Growth of Esophageal Cancer Cells Through Wnt/ β-Catenin Pathway
ConclusionsHypermethylation in the promoter of miR-216a upregulated HMGB3 and the Wnt/β-catenin pathway, resulting in enhanced EC progression.
Source: Frontiers in Oncology - March 23, 2021 Category: Cancer & Oncology Source Type: research
LncRNA CASC9 promotes proliferation, migration and apoptosis of hepatocellular carcinoma cells by down-regulating miR-424-5p.
CONCLUSION: CASC9 reduced proliferation, invasion and migration and induced apoptosis in HCC cells by inhibiting miR-424-5p. LncRNAs, long non-coding RNAs; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; CASC9, cancer sensitivity 9; ESCC, esophageal squamous cell carcinoma; qRT-PCR, quantitative reverse transcription polymerase chain reaction; ATCC, American Type Culture Collection; DMEM, Dulbecco's Modified Eagle Medium; CCK-8, cell counting kit-8; RIPA, radio-immunoprecipitation assay; SDS-PAGE, sodium dodecylsulphate polyacrylamide gel electrophoresis; PVDF, polyvinylidene fluoride; GAPDH, glyceraldehyde-3-phosph...
Source: Annals of Hepatology - December 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research
GPR120 promotes radiation resistance in esophageal cancer via regulating AKT and apoptosis pathway
The aim of the study is to investigate the role of GPR120 on the biological behavior of esophageal cancer cells in the setting of radiation and explore the mechanism. GPR120 knockdown was fulfilled by siRNA-mediated effects in two esophageal cancer cell lines Eca109 and EC9706. Colony formation, survival fraction calculation, viable cell evaluation by cell counting kit-8 assay and cell apoptosis analysis by phycoerythrin annexin V and 7-amino-actinomycin (7-AAD) staining and the flow cytometry examination was evaluated in Eca109 and EC9706 under the treatment of different radiation dosage. The mechanisms were explored by t...
Source: Anti-Cancer Drugs - December 23, 2020 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata
Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects of the crude extract of a South African medicinal plant, Cotyledon orbiculata, on cell survival of colon (HCT116) and esophageal (OE33 and KYSE70) cancer cell lines. Using RNASeq, we discovered that the extract interfered with mRNA regulatory pathways. The extract caused hnRNPA2B1 to splice from the hnRNPB1 to the hnRNPA2 isoform, resulting in a switch in the BCL2L1 gene from Bcl-xL to Bcl-xS causing acti...
Source: Frontiers in Oncology - October 8, 2020 Category: Cancer & Oncology Source Type: research
