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Cancer: Esophagus Cancer
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Total 344 results found since Jan 2013.
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression
Int J Biochem Cell Biol. 2022 Feb 24;145:106188. doi: 10.1016/j.biocel.2022.106188. Online ahead of print.ABSTRACTFascin is the main actin-bundling protein in filopodia and is highly expressed in metastatic tumor cells. The overexpression of Fascin has been associated with poor clinical prognosis and metastatic progression. Post-translational modifications of Fascin, such as phosphorylation, can affect the proliferation and invasion of tumor cells by regulating the actin-bundling activity of Fascin. However, the phosphorylation sites of Fascin and their corresponding kinases require further exploration. In the current stud...
Source: The International Journal of Biochemistry and Cell Biology - February 27, 2022 Category: Biochemistry Authors: Zhi-Da Zhang Bing Wen Da-Jia Li Dan-Xia Deng Xiao-Dong Wu Yin-Wei Cheng Lian-Di Liao Lin Long Geng Dong Li-Yan Xu En-Min Li Source Type: research
AKT Serine/Threonine Kinase 2-mediated phosphorylation of Fascin Threonine 403 regulates esophageal cancer progression
Int J Biochem Cell Biol. 2022 Feb 24:106188. doi: 10.1016/j.biocel.2022.106188. Online ahead of print.ABSTRACTFascin is the main actin-bundling protein in filopodia and is highly expressed in metastatic tumor cells. The overexpression of Fascin has been associated with poor clinical prognosis and metastatic progression. Post-translational modifications of Fascin, such as phosphorylation, can affect the proliferation and invasion of tumor cells by regulating the actin-bundling activity of Fascin. However, the phosphorylation sites of Fascin and their corresponding kinases require further exploration. In the current study, w...
Source: The International Journal of Biochemistry and Cell Biology - February 27, 2022 Category: Biochemistry Authors: Zhi-Da Zhang Bing Wen Da-Jia Li Dan-Xia Deng Xiao-Dong Wu Yin-Wei Cheng Lian-Di Liao Lin Long Geng Dong Li-Yan Xu En-Min Li Source Type: research
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression
Int J Biochem Cell Biol. 2022 Feb 24;145:106188. doi: 10.1016/j.biocel.2022.106188. Online ahead of print.ABSTRACTFascin is the main actin-bundling protein in filopodia and is highly expressed in metastatic tumor cells. The overexpression of Fascin has been associated with poor clinical prognosis and metastatic progression. Post-translational modifications of Fascin, such as phosphorylation, can affect the proliferation and invasion of tumor cells by regulating the actin-bundling activity of Fascin. However, the phosphorylation sites of Fascin and their corresponding kinases require further exploration. In the current stud...
Source: The International Journal of Biochemistry and Cell Biology - February 27, 2022 Category: Biochemistry Authors: Zhi-Da Zhang Bing Wen Da-Jia Li Dan-Xia Deng Xiao-Dong Wu Yin-Wei Cheng Lian-Di Liao Lin Long Geng Dong Li-Yan Xu En-Min Li Source Type: research
Dexmedetomidine inhibits the growth and metastasis of esophageal cancer cells by down-regulation of lncRNA MALAT1
This study aims to evaluate the effect of dexmedetomidine (DEX)-on esophageal cancer (EC) via regulating long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The effect of DEX on MALAT1 expression and EC cell viability was detected. EC cells were divided into Blank, DEX, scrambled/MALAT1 siRNA, and DEX + control/MALAT1 groups, followed by a series of experiments including quantitative reverse-transcription polymerase chain reaction (qRT-PCR), western blotting, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT), Annexin V-FITC/PI staining, wound healing, and Transwell...
Source: Cancer Control - February 24, 2022 Category: Cancer & Oncology Authors: Wei Zhang Li Zhang Xiao-Jun Cai Dong Li Feng-Jun Cao Zhi-Gang Zuo Ying Song Xiong-Jie Yu Shan Liu Source Type: research
Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma < em > via < /em > the PI3K/AKT pathway
CONCLUSION: Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway; thus, DDX51 might be a therapeutic target for ESCC.PMID:35125830 | PMC:PMC8790558 | DOI:10.3748/wjg.v28.i4.464
Source: World Journal of Gastroenterology - February 7, 2022 Category: Gastroenterology Authors: Dong-Xin Hu Qi-Feng Sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Source Type: research
