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Cancer: Esophagus Cancer
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Total 344 results found since Jan 2013.
GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Autocrine motility factor receptor promotes the malignancy of glioblastoma by regulating cell migration and invasion
CONCLUSION: This study suggests that AMFR could be used as a therapeutic strategy for the clinical treatment of glioblastoma.PMID:37703903 | DOI:10.1080/01616412.2023.2257463
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Yao Zhang Xiuping Wang Guanghui Chen Yajing Lu Qiang Chen Source Type: research
RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signalling
AbstractChemo-resistance has been identified as a crucial factor contributing to tumor recurrence and a leading cause of worse prognosis in patients with ESCC. Therefore, unravel the critical regulators and effective strategies to overcome drug resistance will have a significant clinical impact on the disease. In our study we found that RNF149 was upregulated in ESCC and high RNF149 expression was associated with poor prognosis with ESCC patients. Functionally, we have demonstrated that overexpression of RNF149 confers CDDP resistance to ESCC; however, inhibition of RNF149 reversed this phenomenon both in vitro and in vivo...
Source: Medical Oncology - September 2, 2023 Category: Cancer & Oncology Source Type: research
Knockdown of ACC1 promotes migration of esophageal cancer cell
Conclusion: Knockdown of ACC1 promotes the migration of KYSE-450 cell by up-regulating HSP27 and increasing histone acetylation.PMID:37355466 | DOI:10.3760/cma.j.cn112152-20210517-00383
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: H Qian C W Gu Y Z Liu B S Zhao Source Type: research
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway
Conclusion: The findings of this study reveal that Carbon ion knockdown was shown to downregulate LIF in ESCC cells. LIF is involved in ESCC proliferation and inhibited the ESCC cell proliferation by activating the STAT3 signaling pathways.PMID:37057285 | PMC:PMC10088534 | DOI:10.7150/jca.81222
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Hongtao Luo Zhen Yang Qiuning Zhang Tingdong Li Ruifeng Liu Shuangwu Feng Zhiqiang Liu Shilong Sun Junru Chen Xiaohu Wang Xiaoling Xie Source Type: research
CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
CONCLUSION: CCT6A facilitates ESCC malignant activities by activating the TGF-β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.PMID:37017854 | DOI:10.1007/s11845-023-03357-y
Source: Cancer Control - April 5, 2023 Category: Cancer & Oncology Authors: Xiuli Xia Shushan Zhao Wenting Chen Chao Xu Dongqiang Zhao Source Type: research
Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/ < em > β < /em > -Catenin Signaling Pathway
CONCLUSIONS: The data showed that Rab8A was transcriptionally regulated by PEA3 and promoted the malignant behaviors of esophagus cancer cells by activating the Wnt/β-catenin pathway. The above results indicated that Rab8A may be considered as a promising biomarker for diagnosis and precision treatment in esophagus cancer.PMID:36815135 | PMC:PMC9940983 | DOI:10.1155/2023/8143581
Source: Disease Markers - February 23, 2023 Category: Laboratory Medicine Authors: Shusheng Cai Xiumei Liu Weiran Gao Lianhua Ye Qiming Zhong Xin Zhang Source Type: research
ANXA2 as a novel substrate of FBXW7 promoting esophageal squamous cell carcinoma via ERK phosphorylation
In conclusion, this study provided evidence that FBXW7 loss of function could promote esophageal cancer through ANXA2 overexpression, and this novel regulation pathway may be used as an efficient target for ESCC treatment.PMID:36758484 | DOI:10.1016/j.bbrc.2023.01.082
Source: Biochemical and Biophysical Research communications - February 9, 2023 Category: Biochemistry Authors: Zongfei Li Yunzhi Pan Jiayi Yao Yingyin Gao Yulan Qian Minxue Zheng Sai Ma Source Type: research
RNF6 activates TGF- β1/c-Myb pathway to promote EMT in esophageal squamous cell carcinoma
ConclusionRNF6 promotes the proliferation, invasion, and migration of ESCC cells possibly by activating the TGF-β1/c-Myb pathway and affects the progression of ESCC.
Source: Frontiers in Oncology - February 9, 2023 Category: Cancer & Oncology Source Type: research
Correlation of 3'-Phosphoadenosine-5'-Phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous carcinoma
CONCLUSIONS: PAPSS1 may be an ESCC suppressor gene, and its specific molecular mechanism in ESCC needs to be further studied.PMID:36734141 | DOI:10.14670/HH-18-590
Source: Histology and Histopathology - February 3, 2023 Category: Cytology Authors: Xuyou Zhu Peipei Zhu Xue Chen Long Zhang Caixia Wu Haoyang Zhang Xiaoying Shen Yao Qi Mingmin Chen Shunli Wang Xianghua Yi Source Type: research
