GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma

Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell function experiment, we found that knockdown of HDAC9 would inhibit proliferation, migration and invasion of TE-1/CDDP cells. In addition, knockdown of HDAC9 could inhibit the expression of PAI-1, AKT, and ERK. Taken together, the findings of the present study indicated that the crucial role of HDAC9 in cisplatin resistance of esophageal cancer and related to PAI, AKT and ERK protein expression. This suggest that HDAC9 is a potential target gene for treatment of cisplatin resistance in esophageal cancer.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research