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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
IJERPH, Vol. 19, Pages 8118: The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC
In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of NQO1 significantly decreased the levels of the cyclin E-CDK2 complex, inhibiting the G0/G1 to S phase cell cycle progression and tr...
Source: International Journal of Environmental Research and Public Health - July 1, 2022 Category: Environmental Health Authors: Qianlei Yang Rui Yan Yuemei Mo Haixuan Xia Hanyi Deng Xiaojuan Wang Chunchun Li Koichi Kato Hengdong Zhang Tingxu Jin Jie Zhang Yan An Tags: Article Source Type: research
Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration
In conclusion, this is the first to report the potential function of FAT4 in NSCLC. Hence, FAT4 could be used as a promising prognostic and immunological biomarker for NSCLC.
Source: Cancer Medicine - June 30, 2022 Category: Cancer & Oncology Authors: Yue Ning,
Yang Yang,
Hongmei Zheng,
Yuting Zhan,
Hongjing Zang,
Qiuyuan Wen,
Jinwu Peng,
Songqing Fan Tags: RESEARCH ARTICLE Source Type: research
LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription
Exp Mol Med. 2022 Jun 27. doi: 10.1038/s12276-022-00791-3. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and tumor progression. However, the roles and mechanisms of lncRNAs in ESCC require further exploration. Here, in combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS and Transwell assays to screen functional lncRNAs that were overexpressed in ESCC. TMPO-AS1 expressi...
Source: Molecular Medicine - June 27, 2022 Category: Molecular Biology Authors: Xiao-Jing Luo Ming-Ming He Jia Liu Jia-Bo Zheng Qi-Nian Wu Yan-Xing Chen Qi Meng Kong-Jia Luo Dong-Liang Chen Rui-Hua Xu Zhao-Lei Zeng Ze-Xian Liu Hui-Yan Luo Source Type: research
Cancers, Vol. 14, Pages 3122: Cordycepin (3 & prime;-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers, Vol. 14, Pages 3122: Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers doi: 10.3390/cancers14133122
Authors:
Su-Chan Lee
Lujain Alaali
HyukJean Kwon
Mohammed Rigi
Charles G. Eberhart
Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3&prime;-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of sever...
Source: Cancers - June 25, 2022 Category: Cancer & Oncology Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Tags: Article Source Type: research
Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry
ConclusionsCD146 is a novel mediator of both angiogenesis and vasculogenic mimicry in uveal melanoma. Its antibody AA98 has the potency to be developed as a new antibody drug for treating uveal melanoma. Our results warrant further assessment of CD146 as a potential target to improve therapeutic management of uveal melanoma in a clinical setting.
Source: Cellular Oncology - June 18, 2022 Category: Cancer & Oncology Source Type: research
Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/ β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6
ConclusionSOST silencing may facilitate the malignant progression of UM cells through activating Wnt/β-catenin signaling. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
Source: Frontiers in Oncology - June 17, 2022 Category: Cancer & Oncology Source Type: research
Dual inhibition of autophagy and PI3K/mTOR pathway as a potential therapeutic strategy against laryngeal squamous cell carcinoma
CONCLUSIONS: NVP-BEZ235 exerted potent antitumor effects on LSCC, especially when combined with the autophagy inhibitor both in vitro and vivo, providing convincing experimental data for new molecular targeted therapy for LSCC.PMID:35706786 | PMC:PMC9189222 | DOI:10.21037/tcr-21-2325
Source: Cell Research - June 16, 2022 Category: Cytology Authors: Hui-Ying Huang Ke-Nan Li Hui-Ching Lau Chi-Yao Hsueh Ning Cong Ming Zhang Source Type: research
CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling
In this study, we aimed to investigate the engagement of CD44, a cancer stemness marker functioning in the control of cell growth and motility, in OSCC malignancy under the influence of MRE11. We found that overexpression of MRE11 enhanced CD44 expression and tumorsphere formation in OSCC cells, whereas knockdown of MRE11 reduced these phenomena. In addition, the MRE11-promoted tumorsphere formation or cell migration ability was compromised in OSCC cells carrying siRNA that targets CD44, as was the MRE11-promoted AKT phosphorylation. These were further supported by analyzing clinical samples, where higher CD44 expression w...
Source: Cancer Control - May 28, 2022 Category: Cancer & Oncology Authors: Shyng-Shiou F Yuan Amos C Hung Ching-Wei Hsu Ting-Hsun Lan Chang-Wei Su Tsung-Chen Chi Yu-Chiuan Chang Yuk-Kwan Chen Yen-Yun Wang Source Type: research
Metabolism-Related Bioinformatics Analysis Reveals That HPRT1 Facilitates the Progression of Oral Squamous Cell Carcinoma In Vitro
CONCLUSIONS: MRGs play an important role in the development of OSCC. Furthermore, HPRT1 might be an independent biomarker of OSCC and enhance OSCC proliferation, migration, and invasion in vitro; these results emphasize the potential utility of HPRT1 in OSCC therapy.PMID:35586208 | PMC:PMC9110220 | DOI:10.1155/2022/7453185
Source: Journal of Oncology - May 19, 2022 Category: Cancer & Oncology Authors: Hengyu Ye Zenan Zheng Yuxing Song Guangzhao Huang Qingqing Wu Yilong Ai Xiaozhi Lv Source Type: research
