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Cancer: Skin Cancer

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Total 2013 results found since Jan 2013.

Silencing of SiX-4 enhances the chemosensitivity of melanoma cells to Cisplatin
In this study, we investigated whether silencing of SIX4 in a melanoma cell line (A375 cells) in combination with Cisplatin can affect the apoptosis and suppression of cell cycle progression, migration of the melanoma cells. MTT test and colony formation assay was applied to determine the IC50 of Cisplatin and the combined effect of SIX4 siRNA and Cisplatin on the viability and clonogenesis of the A-375 cells. qRT-PCR was performed to determine the c-myc, BCL-2, BAX, MMP-9, CXCR4, and Rock genes expression. Furthermore, flow cytometry was applied to evaluate apoptosis, autophagy, and the cell cycle status in different grou...
Source: Pathology, Research and Practice - November 12, 2022 Category: Pathology Authors: Aysan Fallah Vazirabad Saeed Noorolyai Elham Baghbani Soltanali Mahboob Felor Zargari Shima Rahmani Amin Sorkhabi Nooshin Montazami Pouriya Sameti Behzad Baradaran Source Type: research

GSE161226 HEDGEHOG/GLI Modulates The PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Contributors : Yiyun Sun ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter, and this gene pair synergistically promoted the development of non-small-cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remain obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from the...
Source: GEO: Gene Expression Omnibus - November 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
Chem Biol Interact. 2022 Nov 4:110254. doi: 10.1016/j.cbi.2022.110254. Online ahead of print.ABSTRACTIt is widely accepted that siRNA transfection can promote some off-target effects in the genome; however, little is known about how the cells can respond to the presence of non-viral dsRNA. In the present study, non-targeting control siRNA (NTC-siRNA) was used to evaluate its effects on the activity of pathogen and host-derived nucleic acid-associated signaling pathways such as cGAS-STING, RIG-I, MDA5 and NF-κB in A431 skin cancer cells and BJ fibroblasts. NTC-siRNA treatment promoted cytotoxicity in cancer cells. Furtherm...
Source: Chemico-Biological Interactions - November 7, 2022 Category: Molecular Biology Authors: Gabriela Betlej Dominika B łoniarz Anna Lewi ńska Maciej Wnuk Source Type: research

Cancers, Vol. 14, Pages 5363: Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination
i Marco Benazzo Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Silvia Pisani Giulia Bertino Adriele Prina-Mello Laura Deborah Locati Simone Mauramati Ida Genta Rossella Dorati Bice Conti Marco Benazzo Tags: Review Source Type: research

Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling
CONCLUSIONS: CLIC1 expression increases during esophageal carcinogenesis and it may functionally contribute to the progression of ESCC through growth promotion effects by promoting the mTOR and downstream signaling pathway. CLIC1 therefore constitutes a candidate molecular biomarker of ESCC.PMID:36252281 | DOI:10.1016/j.tranon.2022.101560
Source: Translational Oncology - October 17, 2022 Category: Cancer & Oncology Authors: Huiwu Geng Cheng Feng Zhangran Sun Xu Fan Yiqing Xie Jinghua Gu Libin Fan Gang Liu Chao Li Rick F Thorne Xu Dong Zhang Xinying Li Xiaoying Liu Source Type: research

GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Cancers, Vol. 14, Pages 4776: Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia
Conclusion: Our results suggest that CAXII and the Hh pathway are relevant in melanoma invasion and may be novel and promising therapeutical targets for melanoma clinical management.
Source: Cancers - September 29, 2022 Category: Cancer & Oncology Authors: Gaia Giuntini Federica Coppola Alessandro Falsini Irene Filippi Sara Monaci Antonella Naldini Fabio Carraro Tags: Article Source Type: research

APOBEC3B is overexpressed in cervical cancer and promotes the proliferation of cervical cancer cells through apoptosis, cell cycle, and p53 pathway
ConclusionsTaken together, our study implies that A3B promotes cell proliferation, migration, and cell cycle and inhibits cancer cell apoptosis through the p53-mediated signaling pathway. Moreover, A3B could also contribute to chemoresistance in cervical cancer cells. It may be a potential diagnostic biomarker and therapeutic target for chemoresistant cervical cancers.
Source: Frontiers in Oncology - September 29, 2022 Category: Cancer & Oncology Source Type: research

The paranuclear dot in Merkel cell carcinoma, how does it form and what does it do?
Background and aims: Staining for Cytokeratin 20 (CK20) and other intermediate filaments in a paranuclear dot pattern is a histological feature used to diagnose the neuroendocrine skin cancer Merkel cell carcinoma (MCC). The functional significance of these paranuclear protein aggregates is unknown. Therefore, we sought to investigate the structure and function of the paranuclear dot in MCC. Methods: In native tumors and MCC cell lines we used: immunostaning, microscopy, chemical inhibition, siRNA knockdown, and cell death modulators to study the paranuclear dot.
Source: Journal of Investigative Dermatology - September 21, 2022 Category: Dermatology Authors: Natasha T. Hill, Loren Collado, Tyler Kellenberger, Kunio Nagashima, Serena Vilasi, Paul W. Harms, Isaac Brownell Source Type: research

WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis
Conclusion: WZB117 enhanced the anti-tumor effect of apatinib against melanoma via modulating glycolysis by blocking the STAT3/PKM2 axis, which suggested the combination of apatinib with WZB117 could be a potential therapeutic candidate for melanoma.
Source: Frontiers in Pharmacology - September 16, 2022 Category: Drugs & Pharmacology Source Type: research

MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma
This study aimed to elucidate its expression pattern and functional roles as well as clinical significance in HNSCC. The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and immunohistochemistry (IHC) were utilized to determine the MMP1 expression pattern and the associations between its expression and patients' outcome in HNSCC. Mice tongue squamous cell carcinoma model induced by 4-nitroquinoline 1-oxide (4NQO) and siRNA-mediated cellular assay in vitro were utilized to evaluate the oncogenic role of MMP1. The biological functions and cancer-related pathways involved in MMP1-related genes were found through bio...
Source: Computational and Mathematical Methods in Medicine - September 15, 2022 Category: Statistics Authors: Wei Zhang Xinghong Huang Rong Huang Hong Zhu Pu Ye Xuyang Lin Shuangyue Zhang Meng Wu Feng Jiang Source Type: research

Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1 α-EphA2-Laminin-5γ2 network in human oral cancer
J Cell Commun Signal. 2022 Sep 5. doi: 10.1007/s12079-022-00693-z. Online ahead of print.ABSTRACTVasculogenic mimicry (VM), defined as an endothelial cell independent alternative mechanism of blood and nutrient supply by dysregulated tumor cells, is associated with poor prognosis in oral squamous cell carcinoma (OSCC). Here we aim to investigate the underlying molecular mechanism of the synergistic effect of phytochemical Lupeol and standard microtubule inhibitor Paclitaxel in reversing the hypoxia induced VM formation in OSCC. The results demonstrated that the hypoxia induced upregulation of HIF-1α led to augmentation of...
Source: Journal of Cell Communication and Signaling - September 5, 2022 Category: Molecular Biology Authors: Depanwita Saha Debarpan Mitra Neyaz Alam Sagar Sen Saunak Mitra Mustafi Pradip K Majumder Biswanath Majumder Nabendu Murmu Source Type: research