Filtered By:
Cancer: Skin Cancer
This page shows you your search results in order of date. This is page number 11.
Order by Relevance | Date
Total 2013 results found since Jan 2013.
Ru(II)-modified TiO < sub > 2 < /sub > nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma
Biomaterials. 2022 Aug 24;289:121757. doi: 10.1016/j.biomaterials.2022.121757. Online ahead of print.ABSTRACTThe alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@Ru@siRNA is constructed from a ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA of hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, TiO2@Ru@siRNA can elicit both Type I and Type II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, and O...
Source: Biomaterials - September 4, 2022 Category: Materials Science Authors: Jia-Ying Zhou Wen-Jin Wang Chen-Yu Zhang Yu-Yi Ling Xiao-Jing Hong Qiao Su Wu-Guo Li Zong-Wan Mao Bin Cheng Cai-Ping Tan Tong Wu Source Type: research
GSE205981 RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of lncRNA LINC00094 (SERLOC)
Contributors : Minna Piipponen ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long non-coding RNAs (lncRNAs) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n=8) and normal human epidermal keratinocytes (NHEKs, n=4) revealed overexpression of long intergenic ncRNA (LINC00094) in cSCC cells (GSE66412). We wanted...
Source: GEO: Gene Expression Omnibus - August 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway
In this study, 4-phenylbutyric acid (4PBA, a chemical chaperone) and small interference RNA (siRNA) knockdown of C/EBP Homologous Protein (CHOP)/growth arrest- and DNA damage-inducible gene 153(GAD153) blocked NPC-402-mediated autophagy induction, thus confirming the role of ER stress and autophagy in melanoma cell death. NPC-402 induced oxidative stress and apoptosis in melanoma cells, which were effectively mitigated by treatment with N-acetylcysteine (NAC). In vivo studies showed that intraperitoneal (i.p.) injection of NPC-402 at 10 mg/kg (5 days in 1 week) significantly retarded angiogenesis in the Matrigel plug assay...
Source: Frontiers in Oncology - August 2, 2022 Category: Cancer & Oncology Source Type: research
CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19 & amp;21 in oral squamous cell carcinoma
ConclusionCCR7 in OSCC cells promoted recruitment and M2-polarization of THP-1 derived macrophages in vitro by regulating production of CCL19 and CCL21.
Source: Hormones and Cancer - July 29, 2022 Category: Cancer & Oncology Source Type: research
652 EPAC-mTORC1 signaling regulates proliferation of primary melanoma cells and loss of dependence on EPAC signaling correlates with melanoma progression
In this study, we show that pharmacological inhibition or siRNA-mediated knockdown of EPAC selectively inhibits the growth and survival of primary melanoma cells by downregulation of cell cycle proteins and inhibiting the cell cycle progression independent of ERK1/2 phosphorylation.
Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: M.K. Singh, A. Krishnan, A.I. Bhasker, C.I. Rodriguez, E. Castro-Perez, M. Ndiaye, N. Ahmad, H. Khan, S.M. Schieke, V. Setaluri Source Type: research
EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
This study establishes loss of dependency on EPAC-mTORC1 signaling as hallmark of primary melanoma evolution and targeting this escape mechanism is a promising strategy for metastatic melanoma.PMID:35834616 | DOI:10.1158/1541-7786.MCR-22-0026
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Aishwarya Krishnan Aishwarya I Bhasker Mithalesh K Singh Carlos I Rodriguez Edgardo Castro-Perez Sarah Altameemi Marcos Lares Hamidullah Khan Mary Ndiaye Nihal Ahmad Stefan M Schieke Vijayasaradhi Setaluri Source Type: research
The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC
In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of NQO1 significantly decreased the levels of the cyclin E-CDK2 complex, inhibiting the G0/G1 to S phase cell cycle progression and tr...
Source: Cell Research - July 9, 2022 Category: Cytology Authors: Qianlei Yang Rui Yan Yuemei Mo Haixuan Xia Hanyi Deng Xiaojuan Wang Chunchun Li Koichi Kato Hengdong Zhang Tingxu Jin Jie Zhang Yan An Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
