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Cancer: Skin Cancer
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Total 2013 results found since Jan 2013.
LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
CONCLUSIONS: LAMC2 interacts with autophagy to regulate OSCC metastasis, invasion, and proliferation via the PI3K/AKT/mTOR pathway. LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration, invasion, and proliferation.PMID:37415741 | PMC:PMC10319602 | DOI:10.32604/or.2023.029064
Source: Oncology Research - July 7, 2023 Category: Cancer & Oncology Authors: Fayu Shan Lanlan Liang Chong Feng Hongbao Xu Zirou Wang Weili Liu Lingling Pu Zhaoli Chen Gang Chen Xinxing Wang Source Type: research
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth
ConclusionCollectively, these results indicate that PFKP expression in melanoma cells increases proliferation and glycolytic activity in vitro and promotes tumorigenesis in vivo, suggesting that suppression of PKFP and inhibition of glycolysis may potently suppress melanoma progression.
Source: Clinical and Translational Oncology - June 25, 2023 Category: Cancer & Oncology Source Type: research
Knockdown of ACC1 promotes migration of esophageal cancer cell
Conclusion: Knockdown of ACC1 promotes the migration of KYSE-450 cell by up-regulating HSP27 and increasing histone acetylation.PMID:37355466 | DOI:10.3760/cma.j.cn112152-20210517-00383
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: H Qian C W Gu Y Z Liu B S Zhao Source Type: research
Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors
Corona Virus Disease 2019 (COVID-19) continues to be a burden for human health since its outbreak in Wuhan, China in December 2019. Recently, the emergence of new variants of concerns (VOCs) is challenging for vaccines and drugs efficiency. In severe cases, SARS-CoV-2 provokes inappropriate hyperinflammatory immune responses leading to acute respiratory distress syndrome (ARDS) and even death. This process is regulated by inflammasomes which are activated after binding of the viral spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2) receptor and triggers innate immune responses. Therefore, the formation of...
Source: Frontiers in cellular and infection microbiology - June 9, 2023 Category: Microbiology Source Type: research
Advances in chitosan-based drug delivery systems in melanoma: A narrative review
Curr Med Chem. 2023 May 18. doi: 10.2174/0929867330666230518143654. Online ahead of print.ABSTRACTMelanoma accounts for the minority of skin cancer cases. However, it has the highest mortality rate among the subtypes of skin cancer. At the early stages of the disease, patients show a good prognosis after the surgery, but developing metastases leads to a remarkable drop in patients' 5-year survival rate. Despite the advances made in the therapeutic approaches to this disease, melanoma treatment is still facing several obstacles. Systemic toxicity, water insolubility, instability, lack of proper biodistribution, inadequate c...
Source: Current Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Parisa Maleki Dana Jamal Hallajzadeh Zatollah Asemi Mohammad Ali Mansournia Bahman Yousefi Source Type: research
