Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling

CONCLUSIONS: CLIC1 expression increases during esophageal carcinogenesis and it may functionally contribute to the progression of ESCC through growth promotion effects by promoting the mTOR and downstream signaling pathway. CLIC1 therefore constitutes a candidate molecular biomarker of ESCC.PMID:36252281 | DOI:10.1016/j.tranon.2022.101560

Source: Translational Oncology - October 17, 2022 Category: Cancer & Oncology Authors: Huiwu Geng Cheng Feng Zhangran Sun Xu Fan Yiqing Xie Jinghua Gu Libin Fan Gang Liu Chao Li Rick F Thorne Xu Dong Zhang Xinying Li Xiaoying Liu Source Type: research