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Cancer: Bile Duct Cancer
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Total 113 results found since Jan 2013.
Annexin A1 Is a Potential Prognostic Marker for, and Enhances the Metastasis of, Cholangiocarcinoma
CONCLUSION: These findings strongly imply that ANXA1 contributes to the progression of CCA. ANXA1 can serve as a potential prognostic marker for CCA. Ablation of ANXA1 action may be an alternative strategy to prevent metastasis of CCA.PMID:35225485 | DOI:10.31557/APJCP.2022.23.2.715
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2022 Category: Cancer & Oncology Authors: Kwuntida U Kotepui Sumalee Obchoei Kulthida Vaeteewoottacharn Seiji Okada Sopit Wongkham Kanlayanee Sawanyawisuth Source Type: research
CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
CONCLUSIONS: iCCA patients with higher NOTCH1/HES1/THY1 expression have the worst prognosis, but they are more likely to benefit from Notch signaling inhibition. These findings represent the scientific rationale for testing NOTCH1 inhibitors in clinical trials, taking the first step toward precision medicine for iCCA.PMID:35172861 | DOI:10.1186/s13046-022-02283-8
Source: Cell Research - February 17, 2022 Category: Cytology Authors: Serena Mancarella Grazia Serino Isabella Gigante Antonio Cigliano Silvia Ribback Paola Sanese Valentina Grossi Cristiano Simone Raffaele Armentano Matthias Evert Diego F Calvisi Gianluigi Giannelli Source Type: research
Exosomal p38 Mitogen-activated Protein Kinase Promotes Tumour Repopulation in < em > TP53 < /em > -mutated Bile Duct Cancer Cells
CONCLUSION: Exosomal p38 MAPK plays a pivotal role in tumour repopulation in a TP53-independent manner.PMID:35093873 | DOI:10.21873/anticanres.15533
Source: Cell Research - January 30, 2022 Category: Cytology Authors: Mami Osawa Yasunobu Matsuda Jun Sakata Toshifumi Wakai Source Type: research
Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA
ConclusionHigh ACYP1 expression could influence the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro ACYP1 expression influences the tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins.
Source: Digestive Diseases and Sciences - October 9, 2021 Category: Gastroenterology Source Type: research
High BLM Expression Predicts Poor Clinical Outcome and Contributes to Malignant Progression in Human Cholangiocarcinoma
Molecular mechanisms underlying the tumorigenesis of a highly malignant cancer, cholangiocarcinoma (CCA), are still obscure. In our study, the CCA expression profile data were acquired from The Cancer Genome Atlas (TCGA) database, and differentially expressed genes (DEGs) in the TCGA-Cholangiocarcinoma (TCGA-CHOL) data set were utilized to construct a co-expression network via weighted gene co-expression network analysis (WGCNA). The blue gene module associated with the histopathologic grade of CCA was screened. Then, five candidate hub genes were screened by combining the co-expression network with protein–protein inter...
Source: Frontiers in Oncology - March 22, 2021 Category: Cancer & Oncology Source Type: research
Aberrant GLUT1 Expression Is Associated With Carcinogenesis and Progression of Liver Fluke-associated Cholangiocarcinoma
Conclusion: GLUT1 plays important roles in carcinogenesis and progression of liver fluke-associated CCA. Targeting GLUT1 may be a strategy for treatment of metastasis in liver fluke-associated CCA.
Source: In Vivo - January 5, 2021 Category: Research Authors: THAMRONGWARANGGOON, U., SANGKHAMANON, S., SEUBWAI, W., SARANARUK, P., CHAON, U., WONGKHAM, S. Tags: Experimental Studies Source Type: research
Targeted Modulation of FAK/PI3K/PDK1/AKT and FAK/p53 Pathways by Cucurbitacin B for the Antiproliferation Effect Against Human Cholangiocarcinoma Cells.
This study aimed to investigate the antiproliferative property of cucurbitacin B on KKU-100 CCA cells. The determination of underlying molecular mechanisms was also carried out. The results revealed that cucurbitacin B suppressed growth and replicative ability to form colonies of CCA cells, suggesting the antiproliferative effect of this compound against the cells. Flow cytometry analysis demonstrated that the interfering effect of cucurbitacin B on the CCA cell cycle at the G2/M phase was accountable for its antiproliferation property. Accompanied with cell cycle disruption, cucurbitacin B altered the expression of protei...
Source: The American Journal of Chinese Medicine - September 8, 2020 Category: Complementary Medicine Authors: Klungsaeng S, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L Tags: Am J Chin Med Source Type: research
Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma
Conclusions: Highly expressed AURKA confers poor outcomes in cholangiocarcinoma and may represent a rational therapeutic target.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiwei Ding, Tianlu Huang, Chunyan Peng, Keun Soo Ahn, Jesper B Andersen, Monika Lewinska, Yu Cao, Guifang Xu, Gang Chen, Bo Kong, Helmut Friess, Shanshan Shen, Lewis R Roberts, Lei Wang, Xiaoping Zou Tags: Research Paper Source Type: research
GSE140498 Hepatocytic c-Jun N-terminal kinases (JNK)-1/2 function determines cell fate during carcinogenesis
Contributors : F J Cubero ; M R Mohamed ; M V Boekschoten ; C TrautweinSeries Type : Expression profiling by arrayOrganism : Mus musculusAberrant biliary hyperproliferation resulting from lack of differentiating signals favoring the maintenance of an immature and proliferative phenotype by biliary epithelial cells are ultimately responsible for ducto/cystogenesis and intrahepatic cholangiocarcinoma (CCA) formation. Mitogen-activated protein kinase (MAPK) signaling is pivotal for CCA-related tumorigenesis. In particular, targeted inhibition of JNK signaling has shown therapeutic potential. However, the cell-type specific ro...
Source: GEO: Gene Expression Omnibus - June 8, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma.
Conclusion: Our results indicate that MELK is ubiquitously overexpressed in iCCA, where it may represent a prognostic indicator and a therapeutic target. In particular, the combination of OTSSP167 (or other, more specific MELK inhibitors) with DNA-damaging agents might be a potentially effective therapy for human iCCA.
PMID: 31861475 [PubMed - in process]
Source: Medicina (Kaunas) - December 17, 2019 Category: Universities & Medical Training Authors: Cigliano A, Pilo MG, Mela M, Ribback S, Dombrowski F, Pes GM, Cossu A, Evert M, Calvisi DF, Utpatel K Tags: Medicina (Kaunas) Source Type: research
Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
ConclusionsOverall, our study elucidated a mechanistic framework for the anti ‐CCA effects of celastrol via PTEN/PI3K/Akt pathway.
Source: Cancer Medicine - November 25, 2019 Category: Cancer & Oncology Authors: Biqiang Zhu,
Yunwei Wei Tags: ORIGINAL RESEARCH Source Type: research
CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF- κB pathway promotes cholangiocarcinoma migration and invasion
ConclusionOur data indicate that CD147 promotes the malignant progression of CCA cells by activating the Akt-FoxO3-NF- κB-MCT-1/4 axis. As such, CD147 may serve as a possible target for advanced CCA treatment.
Source: Cellular Oncology - November 14, 2019 Category: Cancer & Oncology Source Type: research
Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway.
CONCLUSION: Low FOXA2 expression negatively affected the prognosis of patients with ICC. Loss of FoxA2 expression could promote intrahepatic bile duct neoplasia partly via activation of the MAPK signaling pathway.
MATERIALS AND METHODS: In all, the data of 85 patients with ICC were retrospectively collected and analyzed. TAA was used to induce ICC in FoxA2-/- mice and WT mice. RNA-sequencing analysis was used to identify the expression of different genes.
PMID: 31689237 [PubMed - as supplied by publisher]
Source: Aging - November 4, 2019 Category: Biomedical Science Authors: Shen J, Zhou Y, Zhang X, Peng W, Peng C, Zhou Q, Li C, Wen T, Shi Y Tags: Aging (Albany NY) Source Type: research
Autophagy Suppression Accelerates Apoptosis Induced by Norcantharidin in Cholangiocarcinoma.
This study aimed to determine whether autophagy suppression accelerates apoptosis induced by norcantharidin in human cholangiocarcinoma cells. The human cholangiocarcinoma cell line QBC939 was incubated in RPMI 1640 medium with or without norcantharidin. Autophagy was induced using HBSS media with Ca2+ and Mg2+ supported by 10 mM HEPES or suppressed by treatment with 3-MA or transfection with siRNA against Atg5. The comparison was drawn between these conditions in mitochondrial membrane potential disturbance, the levels of reactive oxygen species (ROS), apoptotic proteins, and apoptosis. Cholangiocarcinoma cell apoptosis ...
Source: Pathology Oncology Research - October 13, 2019 Category: Pathology Authors: Wang Y, Jiang W, Li C, Xiong X, Guo H, Tian Q, Li X Tags: Pathol Oncol Res Source Type: research
