CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF- κB pathway promotes cholangiocarcinoma migration and invasion

ConclusionOur data indicate that CD147 promotes the malignant progression of CCA cells by activating the Akt-FoxO3-NF- κB-MCT-1/4 axis. As such, CD147 may serve as a possible target for advanced CCA treatment.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research