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Cancer: Bile Duct Cancer

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Total 113 results found since Jan 2013.

High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma.
CONCLUSION: Our results define an important role of HMGB1 in the progression of cholangiocarcinoma, and HMGB1 may serve as a prognostic marker for IHCC patients. PMID: 25805932 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - March 21, 2015 Category: Gastroenterology Authors: Xu YF, Ge FJ, Han B, Yang XQ, Su H, Zhao AC, Zhao MH, Yang YB, Yang J Tags: World J Gastroenterol Source Type: research

Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis
In this study, we studied the role of suppresser of cytokine signaling 3 (SOCS3), a negative feedback regulator of IL-6/STAT3, in the IL-6-induced EMT in CCA. Treatment with IL-6 induced the EMT by decreasing the E-cadherin expression and increasing the expression of N-cadherin and vimentin. Using wound healing and invasion assays, we found that IL-6 promoted cell motility. Further, a stably transfected cell line overexpressing SOCS3 was constructed. Enhanced SOCS3 expression decreased IL-6-induced cell invasion and EMT in parallel with downregulating the IL-6/STAT3 pathway. In contrast, SOCS3 silencing using siRNA exhibit...
Source: Medical Oncology - March 6, 2015 Category: Cancer & Oncology Source Type: research

Modulation of Notch signaling as a therapeutic approach for liver cancer.
Abstract Notch signaling is an evolutionarily conserved pathway crucial for the development and homeostasis of many organs including liver. Aberrant Notch signaling has been mechanistically linked to cancer development including liver cancer. The two principal types of liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHCC). HCCs comprise over 80% of all liver cancers and are the 6th most common malignancy worldwide. Hepatocellular carcinoma is also a cancer with an extremely poor prognosis, being the 3rd commonest cause of cancer-related mortality. Accumulating evidence indicate...
Source: Current Gene Therapy - December 23, 2014 Category: Genetics & Stem Cells Authors: Wu G, Wilson G, George J, Qiao L Tags: Curr Gene Ther Source Type: research

Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents
Conclusions: These results suggest that inhibition of NQO1 could enhance the susceptibility of CCA to an array of chemotherapeutic agents.
Source: Journal of Experimental and Clinical Cancer Research - January 24, 2014 Category: Cancer & Oncology Authors: Ponsilp ZeekpudsaVeerapol KukongviriyapanLaddawan SenggunpraiBanchob SripaAuemduan Prawan Source Type: research

Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis
Extrahepatic cholangiocarcinoma (EHCC) is a cancer with a poor prognosis, and the postoperative survival of patients depends on the existence of invasion and metastasis. The epithelial‐to‐mesenchymal transition (EMT) is an important step in EHCC invasion and metastasis. Forkhead box protein C2 (FOXC2) is a transcription factor that has been reported to induce the EMT. Therefore we examined the correlation between FOXC2 expression and clinical pathological factors, and analysed the function of FOXC2. The expression of FOXC2 in 77 EHCC cases was investigated by immunohistochemical staining, and the relationship between F...
Source: Cancer Science - September 15, 2013 Category: Cancer & Oncology Authors: Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Bolag Altan, Norio Kubo, Kenichiro Araki, Satoshi Wada, Yasushi Mochida, Shigeru Sasaki, Kenji Kashiwabara, Yasuo Hosouchi, Hiroyuki Kuwano Tags: Original Article Source Type: research

Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma
Conclusion: Gankyrin is crucial for CCA carcinogenesis and metastasis by activating IL‐6/STAT3 signaling pathway through downregulating Rb protein. (Hepatology 2013;)
Source: Hepatology - August 26, 2013 Category: Internal Medicine Authors: Tongsen Zheng, Xuehui Hong, Jiabei Wang, Tiemin Pei, Yingjian Liang, Dalong Yin, Ruipeng Song, Xuan Song, Zhaoyang Lu, Shuyi Qi, Jiaren Liu, Boshi Sun, Changming Xie, Shangha Pan, Yuejin Li, Xiaohe Luo, Shuai Li, Xiang Fang, Nishant Bhatta, Hongchi Jiang, Tags: Hepatobiliary Malignancies Source Type: research

Inhibition of Wnt/β‐catenin signaling down‐regulates P‐glycoprotein and reverses multi‐drug resistance of cholangiocarcinoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - July 3, 2013 Category: Cancer & Oncology Authors: Dong‐Yan Shen, Wei Zhang, Xin Zeng, Chang‐Qin Liu Tags: Original Article Source Type: research

The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
Conclusion: Notch1 may induce a migratory effect in ICC by causing an epithelial-mesenchymal transition and activating Rac1 and could serve as a novel diagnostic and therapeutic target in patients with ICC.
Source: BMC Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Qi ZhouYafeng WangBaogang PengLijian LiangJiaping Li Source Type: research