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Cancer: Bile Duct Cancer

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Total 113 results found since Jan 2013.

FOXO1, a Potential Therapeutic Target, Regulates Autophagic Flux, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Human Cholangiocarcinoma QBC939 Cells
Conclusions: Taken together, our study for the first time identified FOXO1 as a potential therapeutic target to cure against human cholangiocarcinoma via regulation of autophagy, oxidative stress and MtD.Cell Physiol Biochem 2018;45:1506 –1514
Source: Cellular Physiology and Biochemistry - February 21, 2018 Category: Cytology Source Type: research

Suppression of 14-3-3 ζ in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine.
Suppression of 14-3-3ζ in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine. Oncol Lett. 2018 Jan;15(1):347-353 Authors: Kittirat Y, Techasen A, Thongchot S, Loilome W, Thanan R, Yongvanit P, Sungkhamanon S, Titapun A, Khuntikeo N, Namwat N Abstract The protein 14-3-3ζ contributes important regulatory functions in several cellular processes via binding to phosphorylated serine/threonine residues, which promotes cell cycle progression, cell proliferation and anti-apoptosis in multiple types of cancer. The aim of the present study...
Source: Oncology Letters - February 3, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt/mTOR ‐independent pathway
In conclusion, suppresses autophagy could increase compound C sensitivity in human CCA. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 31, 2018 Category: Biochemistry Authors: Xiaofang Zhao, Guosong Luo, Ying Cheng, Wenjing Yu, Run Chen, Bin Xiao, Yuancai Xiang, Chunhong Feng, Wenguang Fu, Chunyan Duan, Fuli Yao, Xianming Xia, Qinghua Tao, Mei Wei, Rongyang Dai Tags: Article Source Type: research

Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma.
Abstract Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy. CC treatment options are very limited especially for patients with distant metastasis. Kangai 1 C-terminal interacting tetraspanin (KITENIN) is highly expressed in numerous cancers, but the role of KITENIN in CC remains unknown. Here, we have investigated for the first time the function of KITENIN in human CC cell lines (TFK-1, SZ-1), tissues and a CC mouse model (Alb-Cre/LSL-KRASG12D/p53L/L). KITENIN was expressed in 92,2% of human CC tissues, in murine CC samples and also in human CC cell lines. Knockdown of KITENIN by small i...
Source: Experimental Cell Research - January 20, 2018 Category: Cytology Authors: Bui KC, Barat S, Chen X, Bozko P, Scholta T, Thi Nguyen ML, Bhuria V, Xing J, Toan NL, Song LH, Velavan TP, Sipos B, Wilkens L, Malek NP, Plentz RR Tags: Exp Cell Res Source Type: research

Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1.
CONCLUSIONS: The effect of DcR3 on the growth and apoptosis of cholangiocarcinoma has been demonstrated. DcR3 is not only a predictive marker for malignant tumor but it is also likely to be a potential target for cancer gene therapy. Further studies should focus on exploring the binding ligand of DcR3, the signaling pathway involved, and the molecular mechanism for the regulation of DcR3 expression in cholangiocarcinoma. PMID: 29271385 [PubMed - in process]
Source: Chinese Medical Journal - December 24, 2017 Category: General Medicine Authors: Xu YC, Cui J, Zhang LJ, Zhang DX, Xing BC, Huang XW, Wu JX, Liang CJ, Li GM Tags: Chin Med J (Engl) Source Type: research

Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib.
Authors: Yokoi K, Kobayashi A, Motoyama H, Kitazawa M, Shimizu A, Notake T, Yokoyama T, Matsumura T, Takeoka M, Miyagawa SI Abstract Cholangiocarcinoma (CCC) is a strongly aggressive malignancy for which surgical resection is the only potential curative therapy. Sorafenib, a multikinase inhibitor of the RAF/MEK/ERK pathway, is a molecular-targeted drug that is approved for hepatocellular carcinoma (HCC) but not for CCC. The differences in signaling pathway characteristics under sorafenib treatment between HCC (HLF, Huh7, PLC/PRF/5) and CCC (RBE, YSCCC, Huh28) cell lines were therefore investigated using cell prolif...
Source: Oncology Reports - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sirnaomics' Leading siRNA Therapeutic Candidate, STP705, Granted Orphan Designation for Treatment of Cholangiocarcinoma
GAITHERSBURG, Md., Dec. 6, 2017 -- (Healthcare Sales & Marketing Network) -- Sirnaomics, Inc. (www.sirnaomics.com), a leading biopharmaceutical company in discovery and development of RNAi therapeutics, announced today that the Office of Orphan Product De... Biopharmaceuticals, Oncology, FDA Sirnaomics, Cholangiocarcinoma
Source: HSMN NewsFeed - December 6, 2017 Category: Pharmaceuticals Source Type: news

Disruption of endocytic trafficking protein Rab7 impairs invasiveness of cholangiocarcinoma cells.
CONCLUSIONS: Overexpression of Rab7 in CCA cells was associated with cell invasion, supporting Rab7 as a novel candidate for the development of diagnostic and therapeutic strategies for CCA. PMID: 28946560 [PubMed - in process]
Source: Cancer Biomarkers - September 29, 2017 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

LncRNA-CCAT1 Promotes Migration, Invasion, and EMT in Intrahepatic Cholangiocarcinoma Through Suppressing miR-152
ConclusionsOur results suggested that CCAT1 functions as an oncogenic lncRNA in ICC, which could serve as a potential diagnostic and therapeutic target for ICC patients.
Source: Digestive Diseases and Sciences - September 18, 2017 Category: Gastroenterology Source Type: research

KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma
Conclusions: Our observations suggested KCa3.1 might be a promising novel therapeutic target in intrahepatic cholangiocarcinoma.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Penghong Song, Yehui Du, Wenfeng Song, Hao Chen, Zefeng Xuan, Long Zhao, Jun Chen, Jian Chen, Danjing Guo, Cheng Jin, Yongchao Zhao, Biguang Tuo, Shusen Zheng Tags: Research Paper Source Type: research

c ‑Myc promotes cholangiocarcinoma cells to overcome contact inhibition via the mTOR pathway.
c‑Myc promotes cholangiocarcinoma cells to overcome contact inhibition via the mTOR pathway. Oncol Rep. 2017 Aug 22;: Authors: Luo G, Li B, Duan C, Cheng Y, Xiao B, Yao F, Wei M, Tao Q, Feng C, Xia X, Zhou H, Zhao X, Dai R Abstract The loss of contact inhibition is a hallmark of a wide range of human cancer cells. Yet, the precise mechanism behind this process is not fully understood. c‑Myc plays a pivotal role in carcinogenesis, but its involvement in regulating contact inhibition has not been explored to date. Here, we report that c‑Myc plays an important role in abrogating contact inhibition i...
Source: Oncology Reports - August 31, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Activation of Vimentin is Critical to Promote a Metastatic Potential of Cholangiocarcinoma Cells.
Authors: Saentaweesuk W, Araki N, Vaeteewoottacharn K, Silsirivanit A, Seubwai W, Talabnin C, Muisuk K, Sripa B, Wongkham S, Okada S, Wongkham C Abstract Cholangiocarcinoma (CCA) is a highly metastatic tumor, of which the majority of the patients have short survival due tono effective treatment. Hence, a better understanding regarding CCA metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying the metastatic process. In the present study, a lung metasta...
Source: Oncology Research - August 3, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Platelet ‐Derived Growth Factor Regulates YAP Transcriptional Activity via Src Family Kinase Dependent Tyrosine Phosphorylation
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 29, 2017 Category: Biochemistry Authors: Rory L. Smoot, Nathan W. Werneburg, Takaaki Sugihara, Matthew C. Hernandez, Lin Yang, Christine Mehner, Rondell P. Graham, Steven F. Bronk, Mark J. Truty, Gregory J. Gores Tags: Article Source Type: research

Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398
Activation of FGFR signaling through mutations, amplifications, or fusions involving FGFR1, 2, 3, or 4 is seen in multiple tumors, including lung, bladder, and cholangiocarcinoma. Currently, several clinical trials are evaluating the role of novel FGFR inhibitors in solid tumors. As we move forward with FGFR inhibitors clinically, we anticipate the emergence of resistance with treatment. Consequently, we sought to study the mechanism(s) of acquired resistance to FGFR inhibitors using annotated cancer cell lines. We identified cancer cell lines that have activating mutations in FGFR1, 2, or 3 and treated them chronically wi...
Source: Molecular Cancer Therapeutics - April 2, 2017 Category: Cancer & Oncology Authors: Datta, J., Damodaran, S., Parks, H., Ocrainiciuc, C., Miya, J., Yu, L., Gardner, E. P., Samorodnitsky, E., Wing, M. R., Bhatt, D., Hays, J., Reeser, J. W., Roychowdhury, S. Tags: Small Molecule Therapeutics Source Type: research

Targeting hexokinase II as a possible therapy for cholangiocarcinoma.
Abstract Overexpression of hexokinase 2 (HKII) has been demonstrated in various cancers. A number of in vitro and in vivo studies in several cancers show the significance of HKII in many cellular processes including proliferation, metastasis and apoptosis. However, the role of HKII in Opisthorchis viverrini (Ov) associated cholangiocarcinoma (CCA) is still unknown. In the present study, the expression and roles of HKII were determined in Ov associated CCA. The expression of HKII was investigated in 82 patients with histologically proven CCAs by immunohistochemistry. HKII was distinctively expressed in CCA tissues....
Source: Biochemical and Biophysical Research communications - January 24, 2017 Category: Biochemistry Authors: Thamrongwaranggoon U, Seubwai W, Phoomak C, Sangkhamanon S, Cha'on U, Boonmars T, Wongkham S Tags: Biochem Biophys Res Commun Source Type: research