Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1.

CONCLUSIONS: The effect of DcR3 on the growth and apoptosis of cholangiocarcinoma has been demonstrated. DcR3 is not only a predictive marker for malignant tumor but it is also likely to be a potential target for cancer gene therapy. Further studies should focus on exploring the binding ligand of DcR3, the signaling pathway involved, and the molecular mechanism for the regulation of DcR3 expression in cholangiocarcinoma.
PMID: 29271385 [PubMed - in process]

Source: Chinese Medical Journal - December 24, 2017 Category: General Medicine Authors: Xu YC, Cui J, Zhang LJ, Zhang DX, Xing BC, Huang XW, Wu JX, Liang CJ, Li GM Tags: Chin Med J (Engl) Source Type: research