The Influence of "Omental Cake" Presence on the Completeness of Cytoreduction in Advanced-stage Ovarian Cancer
Conclusion: The presence of "omental cake" is associated with a higher rate of incomplete resections. However, in cases in which complete debulking was achieved, the presence of omental cake was associated with a significantly higher number of digestive tract resections. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: BACALBASA, N., DIACONU, C., ILIESCU, L., SAVU, C., BRATU, O. G., BOLCA, C., CRETOIU, D., FILIPESCU, A., DIMA, S., BALALAU, C., BALESCU, I. Tags: Clinical Studies Source Type: research

Pleural Neutrophil-to-Lymphocyte Ratio May Be Associated With Early Disease Progression in Stage IV Non-small Cell Lung Cancer
Conclusion: Increased pleural NLR is predictive of early disease progression in EGFR mutation wild-type NSCLC patients with MPE. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: LIM, J. U., YEO, C. D., KIM, H. W., KANG, H. S., PARK, C. K., KIM, J. S., KIM, J. W., KIM, S. J., LEE, S. H. Tags: Clinical Studies Source Type: research

Hysterectomy for Recurrent/Residual Cervical Cancer Following Definitive Radiotherapy
Conclusion: Adjuvant hysterectomy could be a treatment of choice for LR cervical cancer post-RT. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: NAKASONE, T., TAIRA, Y., SHIMOJI, Y., ARAKAKI, Y., NAKAMOTO, T., OOYAMA, T., KUDAKA, W., KANESHIMA, I., NISHIHIRA, K., MEKARU, K., AOKI, Y. Tags: Clinical Studies Source Type: research

Successful Management of Esophageal Cancer With Perforation Using Bypass Surgery Followed by Definitive Chemoradiotherapy
Conclusion: Definitive CRT after esophageal bypass surgery is a potential treatment option for locally advanced esophageal cancer with esophageal perforation to improve treatment response and quality of life. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: OHSAWA, M., HAMAI, Y., IBUKI, Y., EMI, M., OKADA, M. Tags: Clinical Studies Source Type: research

Laparoscopic-assisted Esophageal Bypass for T4b Esophageal Tumor as a Bridge to Definitive Therapy
Conclusion: 3D laparoscopic-assisted esophageal bypass can be a safe and feasible approach in patients with advanced mid-esophageal squamous cell carcinoma and esophagobroncial fistula. Additionally to the advantages of laparoscopic surgery, this operation permits oral feeding, and can be used with possible curative intent in patients with adequate response to chemoradiotherapy. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: DAVAKIS, S., SYLLAIOS, A., MPAILI, E., LIAKAKOS, T., CHARALABOPOULOS, A. Tags: Clinical Studies Source Type: research

A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy
Conclusion: We report a case of cytology-proven metastatic iris tumor observed with AS-OCT before and after radiation therapy. This study highlights the potential usefulness of AS-OCT for monitoring changes in tumor size and configuration following radiotherapy. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: MITAMURA, M., KASE, S., SUIMON, Y., ITO, T., ISHIDA, S. Tags: Clinical Studies Source Type: research

Vietnamese Case Series of Hirayama Disease
Conclusion: In the flexion posture, the cervical MRI allows early diagnosis of Hirayama disease and should be considered in patients with the typical clinical symptoms. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: HUNG, N. D., DUC, N. M., VAN, N. T., DUNG, L. T., HA, H. D., HUE, N. D. Tags: Clinical Studies Source Type: research

Endometriosis-associated Clear Cell Carcinoma of the Abdominal Wall After Caesarean Section: A Case Report and Review of the Literature
Conclusion: Clear cell carcinoma is a rare but occurring event. Middle-aged women showing an abdominal wall mass in close relation with a surgical scar from a previous cesarean section must be promptly investigated. Treatment options usually include surgery and chemotherapy with poor results. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: GIANNELLA, L., SERRI, M., MACCARONI, E., DI GIUSEPPE, J., CARPINI, G. D., BERARDI, R., SOPRACORDEVOLE, F., CIAVATTINI, A. Tags: Clinical Studies Source Type: research

Squamous Cell Carcinoma from Abscessed, Mature Cystic Ovarian Teratoma - A Case Report and Literature Review
Conclusion: Although malignisation of mature cystic ovarian teratoma is a rare event, it should not be omitted when mature ovarian teratoma is suspected; however, association between malignant transformation and abscess is a scarcer eventuality. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: BACALBASA, N., CRETOIU, D., HALMACIU, I., DIACONU, C., ILIESCU, L., DIMA, S., NEACSU, A., BALALAU, C., BRATU, O. G., BALESCU, I. Tags: Clinical Studies Source Type: research

Azygos Vein Aneurysm Mimicking a Mediastinal Mass
Conclusion: AVA is a rare pathology that must be taken into consideration during the differential diagnosis of right postero-superior mediastinal masses. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: SAVU, C., MELINTE, A., BALESCU, I., BACALBASA, N. Tags: Clinical Studies Source Type: research

Quantitative Assessment of Interim PET/CT Could Have More Prognostic Relevance than Visual Assessment for Predicting Clinical Outcome of Extranodal Diffuse Large B Cell Lymphoma
Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUV-based assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (SUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow-up of 52.5 months, SUVmax successfully predicted the survival outcomes of patients with one extr...
Source: In Vivo - June 30, 2020 Category: Research Authors: BAEK, D. W., CHO, H. J., KIM, J.-H., SOHN, S. K., SONG, G.-Y., AHN, S.-Y., JUNG, S.-H., AHN, J. S., LEE, J.-J., KIM, H.-J., JEONG, S.-Y., HONG, C. M., MIN, J.-J., MOON, J.-H., YANG, D.-H. Tags: Clinical Studies Source Type: research

Microsatellite Instability Correlated Inflammatory Markers and their Prognostic Value in the Rectal Cancer Following Neoadjuvant Chemoradiotherapy: A Hypothesis-generating Study
Conclusion: There is correlation between inflammatory markers and MSI during CRT and it influences prognosis. Therefore, inflammatory markers might have a role in assessing the microenvironment related to MSI and the immunologic response in rectal cancer. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: LEE, J. H., KANG, B.-H., SONG, C., KANG, S.-B., LEE, H. S., LEE, K.-W., CHIE, E. K., KIM, J.-S. Tags: Clinical Studies Source Type: research

A Monocentric Retrospective Observational Study of Comorbidities in Patients Affected by Autoimmune Bullous Diseases
Conclusion: BP is statistically significantly associated with type 2 diabetes mellitus and neuropsychiatric diseases. The correlation with neuropsychiatric pathologies is interesting for the possible bidirectional role in their etiology. The association with type 2 diabetes mellitus could suggest more caution in the administration of systemic corticosteroids, especially in elderly patients. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: FERRANTI, M., GOBBO, G., CICOGNA, G. T., ALAIBAC, M. Tags: Clinical Studies Source Type: research

Correlation Between Demographic and Tumor Characteristics in Non-melanoma Skin Cancers Submitted to Mohs Micrographic Surgery
Background/Aim: Non-melanoma skin cancer (NMSC) is the most prevalent type of cancer in adults. Surgery remains the golden-standard treatment for this disease. Mohs micrographic surgery (MMS), a surgical technique, is based on the three-dimensional histopathological examination of the margin and surgical bed, layer by layer, in the excised tissue allowing for the determination of the location of the residual tumor, for its complete excision, with high cure rates and preservation of the unaffected tissue. The aim of this study was to present the epidemiological characteristics of the population that was submitted to MMS, as...
Source: In Vivo - June 30, 2020 Category: Research Authors: WEIMANN, E. T. S., BRANDAO, C. M., TERZIAN, L. R., PASCHOAL, F. M., FILHO, C. D. S. M., CRIADO, P. R. Tags: Clinical Studies Source Type: research

Taller-than-wide Thyroid Nodules With Microcalcifications Are at High Risk of Malignancy
Background/aim: Previous studies have shown that there may be a diversity in the ultrasonographic (US) features discriminating a malignant from a benign thyroid nodule. We determined the reliability of the specific nodule shape in combination with other US features in predicting thyroid carcinomas. Patients and Methods: This was a retrospective single-center study investigating the association of the morphological characteristics of nodular goiters from preoperative US and color Doppler images with malignancy based on pathology. Results: We evaluated 254 thyroid nodules (malignant, n=131) from 205 patients. Multivariable l...
Source: In Vivo - June 30, 2020 Category: Research Authors: PAPAPOSTOLOU, K. D., EVANGELOPOULOU, C. C., IOANNIDIS, I. A., KASSI, G. N., MORFAS, K. S., KARAMINAS, N. I., KARGA, H. J. Tags: Clinical Studies Source Type: research

Serum CEA and CYFRA Levels in ALK-rearranged NSCLC Patients: Correlation With Distant Metastasis
Conclusion: Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: NUMATA, T., ENDO, T., YANAI, H., OTA, K., YAMAMOTO, Y., SHIMIZU, K., YAMADA, H., HAYASHIHARA, K., OKAUCHI, S., SATOH, H., YAMADA, Y., TAMURA, T., SAITO, K., KIKUCHI, N., KURISHIMA, K., ISHIKAWA, H., WATANABE, H., SHIOZAWA, T., HIZAWA, N., FUNAYAMA, Y., HA Tags: Clinical Studies Source Type: research

The Lymph Node Ratio Is an Independent Prognostic Factor in Esophageal Cancer Patients Who Receive Curative Surgery
Background/Aim: We investigated the clinical impact of the lymph node ratio (LNR) on overall survival (OS) and recurrence-free survival (RFS) in esophageal cancer patients who underwent curative surgery. Patients and Methods: One hundred twenty patients who underwent curative surgery for esophageal cancer between 2005 and 2017 were included in this study. The LNR was defined as the ratio of the number of metastatic lymph nodes (LNs) to the total number of harvested LNs. Results: A lymph node ratio of 10% was regarded as the optimal critical point for classification based on the overall survival rate. The 3-year and 5-year ...
Source: In Vivo - June 30, 2020 Category: Research Authors: YUKAWA, N., AOYAMA, T., TAMAGAWA, H., TAMAGAWA, A., ATSUMI, Y., KAWAHARA, S., MAEZAWA, Y., KANO, K., MURAKAWA, M., KAZAMA, K., NUMATA, M., OSHIMA, T., MASUDA, M., RINO, Y. Tags: Clinical Studies Source Type: research

Laparoscopic vs. Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m2
Conclusion: Laparoscopic and open surgeries had similar long-term outcomes for obese patients. Laparoscopic surgery is an effective option for this population. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KAZAMA, K., NUMATA, M., AOYAMA, T., ONODEARA, A., HARA, K., ATSUMI, Y., TAMAGAWA, H., GODAI, T., SAEKI, H., SAUGUSA, Y., OKAMOTO, H., SHIOZAWA, M., OSHIMA, T., YUKAWA, N., MASUDA, M., RINO, Y. Tags: Clinical Studies Source Type: research

Radical Hysterectomy for Cervical Cancer in Patients With Uterine Prolapse
Conclusion: Although it represents an unusual situation, malignant transformation of the uterine cervix might be encountered even in cases presenting uterine prolapse. In such cases, the therapeutic strategy should be tailored according to the stage of the disease. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: BACALBASA, N., HALMACIU, I., CRETOIU, D., BALALAU, C., DIACONU, C., ILIESCU, L., GORECKI, G., BOLCA, C., NEACSU, A., BALESCU, I. Tags: Clinical Studies Source Type: research

Hepatic Xanthogranuloma that Originated from a Liver Cyst and Mimicked a Malignant Tumor
Conclusion: The patient was diagnosed with a hepatic xanthogranuloma that originated from a hemorrhagic liver cyst. Intracystic hemorrhage may be one of the reasons for hepatic xanthogranuloma formation. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: ODA, E., BEPPU, T., KINOSHITA, K., YAMAMURA, K., SATO, N., YUKI, H., CHIYONAGA, S., MOTOHARA, T., KOMOHARA, Y., AKAHOSHI, S. Tags: Clinical Studies Source Type: research

Management of Peritoneal Carcinomatosis With Cytoreductive Surgery Combined With Intraperitoneal Chemohyperthermia at a Novel Italian Center
Background: Peritoneal carcinomatosis (PC) is a common manifestation of many gastrointestinal (GI) malignancies and is an advanced stage that is often associated with disseminated disease. Considerable progress has been made to achieve safe elimination of macroscopic disease using cytoreductive surgery (CRS) and more recently in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of microscopic disease or disease with minimal volume. The aim of this study was to assess the effects of such procedures on the quality of life (QoL), the long-term benefit and the functional status of the treated...
Source: In Vivo - June 30, 2020 Category: Research Authors: FAVIANA, P., BOLDRINI, L., MUSCO, B., FERRARI, M., GRECO, A., FORNARO, L., MASI, G., FORFORI, F., RICCI, S., BROGI, A., BASOLO, F., FALCONE, A., GADDUCCI, A., LIPPOLIS, P. V. Tags: Clinical Studies Source Type: research

Synchronous Bilateral Carcinoma of the Ureters. Report of a Case and a Short Discussion of the Literature
Conclusion: We believe that conservative treatment is a viable therapeutic option for simultaneous bilateral renal pelvic and/or ureteral tumors in selected patients. Yet, this treatment has seldom been performed, although standard therapy with bilateral nephroureterectomy inevitably requires the support of hemodialysis or renal transplantation. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: SIDIROPOULOS, D., KAPOGIANNIS, F., KRIPOURI, P., FILIPPOU, D., VLASSIS, K. Tags: Clinical Studies Source Type: research

Epidemiological Analysis of Zygomatic Bone Fractures in North-Western Romanian Population: A 10-Year Retrospective Study
Conclusions: Interpersonal violence as a cause of zygomatic bone fractures is currently reaching epidemic proportions. Taking legal measures to prevent aggression is a public health emergency that would considerably decrease the incidence of these fractures in our population. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: ŢENT, P. A., JUNCAR, R.-I., JUNCAR, M. Tags: Clinical Studies Source Type: research

A Rare Case of Inflammatory Myofibroblastic Tumor of the Prostate and Review of the Literature
Conclusion: This was a case of IMT arising in the prostate. Pathologists should be aware of such an entity whenever they see spindle-cell lesions in the transrectal needle biopsy of the prostate. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KIM, M. S., LIM, S.-C. Tags: Clinical Studies Source Type: research

Laparoscopic Treatment of a Hepatoduodenal Ligament Schwannoma With Infrared Indocyanine Green Fluorescence
Schwannomas occurring in the hepatoduodenal ligament are extremely rare, with only four cases reported. Here, we describe a case of a 30-mm schwannoma that originated in the hepatoduodenal ligament of a 38-year-old female found during a periodic medical check-up. Magnetic resonance imaging demonstrated a tumor in the hepatoduodenal ligament. Following an ultrasound-guided microbiopsy, histological examination showed solitary fibrous tumor or schwannomas in the liver or originating from the hepαtoduodenal ligament. The relationship between the tumor and associated organs was confirmed intraoperatively, and the tumor w...
Source: In Vivo - June 30, 2020 Category: Research Authors: TOMIOKA, K., AOKI, T., KOIZUMI, T., ELEWA, A., KUSANO, T., MATSUDA, K., NOGAKI, K., TASHIRO, Y., WADA, Y., HAKOZAKI, T., SHIBATA, H., HIRAI, T., YAMAZAKI, T., SAITO, K., ENAMI, Y., SUGIURA, I., NAKAJIMA, Y., ARAI, J., KAJIWARA, A., UOZUMI, S., SHIMOZUMA, Tags: Clinical Studies Source Type: research

Implications of Low Serum Albumin as a Prognostic Factor of Long-term Outcomes in Patients With Breast Cancer
We examined the relationship between preoperative serum albumin levels and long-term outcomes in patients with breast cancer. Patients and Methods: We retrospectively analyzed the records of 157 patients who underwent breast cancer surgery at a single institution. We divided the patients into those with
Source: In Vivo - June 30, 2020 Category: Research Authors: FUJII, T., TOKUDA, S., NAKAZAWA, Y., KUROZUMI, S., OBAYASHI, S., YAJIMA, R., SHIRABE, K. Tags: Clinical Studies Source Type: research

A Comparison of 18F-FDG-PET/MRI and 18F-FDG-PET/CT in the Cancer Staging of Locoregional Lymph Nodes
Conclusion: Both methods have a high yield in N-clinical staging with statistically insignificant differences. We assume PET/MRI to be the first-choice method in organ-targeted examinations, for pediatric patients and repeat examinations. In cases of MRI contraindication, PET/CT can be used with no impact on the quality of care. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: SLOUKA, D., KRCAL, J., KOSTLIVY, T., HRABACKA, P., SKALOVA, A., MIRKA, H., TOPOLCAN, O., KUCERA, R. Tags: Clinical Studies Source Type: research

The Number of Harvested LNs Is an Independent Prognostic Factor in Lymph Node Metastasis-negative Patients Who Received Curative Esophagectomy
Background/Aim: The aim of the present study was to evaluate the optimal number of harvested LNs (LNs) in patients who were LN metastasis-negative after curative esophagectomy for esophageal cancer. Patients and Methods: Sixty-one patients who underwent curative surgery for esophageal cancer between 2005 and 2017 and diagnosed as lymph node metastasis-negative were included in this study. Results: The 5-year overall survival rates were 27.8% for 0-20 harvested LNs, 35.7% for 21-30 harvested LNs, 79.4% for 31-40 harvested LNs, and 85.2% for ≥41 harvested LNs. Thirty harvested LNs was regarded as the optimal critical poin...
Source: In Vivo - June 30, 2020 Category: Research Authors: AOYAMA, T., ATSUMI, Y., KAWAHARA, S., TAMAGAWA, H., TAMAGAWA, A., MAEZAWA, Y., KANO, K., MURAKAWA, M., KAZAMA, K., NUMATA, M., OSHIMA, T., YUKAWA, N., MASUDA, M., RINO, Y. Tags: Clinical Studies Source Type: research

Occurrence of Residual Cancer Within Re-excisions After Subcutaneous Mastectomy of Invasive Breast Cancer and Ductal Carcinoma In Situ - A Retrospective Analysis
Conclusion: In every second patient who had first received a subcutaneous mastectomy, no tumor could be detected in the secondary operation despite a previous R1 status. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: PAHMEYER, C., SCHABLACK, A., RATIU, D., THANGARAJAH, F., LUDWIG, S., GRUETTNER, B., MALLMANN, P., MALTER, W., WARM, M., EICHLER, C. Tags: Clinical Studies Source Type: research

High-dose Radiotherapy for Oligo-progressive NSCLC Receiving EGFR Tyrosine Kinase Inhibitors: Real World Data
Conclusion. Hypo-fractionated HDRT plus TKI therapy, is associated with a significant prolongation of disease control (overall PFS: 18.8 months), with manageable side effects. These real-world data support the use of local ablative approaches in oligo-progressive EGFR mut-NSCLC. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: SANTARPIA, M., ALTAVILLA, G., BORSELLINO, N., GIRLANDO, A., MANCUSO, G., PERGOLIZZI, S., PIAZZA, D., PONTORIERO, A., VALERIO, M. R., GEBBIA, V. Tags: Clinical Studies Source Type: research

Clinicopathological Features in Elderly ALK-rearranged Non-small Cell Lung Cancer Patients
Conclusion: Evaluation of ALK gene status and TKI treatment are desirable even for elderly patients. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: MIYAZAKI, K., SATO, S., KODAMA, T., NUMATA, T., ENDO, T., YAMAMOTO, Y., SHIMIZU, K., YAMADA, H., HAYASHIHARA, K., OKAUCHI, S., SATOH, H., YAMADA, Y., TAMURA, T., SAITO, K., KIKUCHI, N., KURISHIMA, K., ISHIKAWA, H., WATANABE, H., SHIOZAWA, T., HIZAWA, N., Tags: Clinical Studies Source Type: research

Prognostic Impact of the Neoadjuvant Rectal Score as Compared With the Tumor Regression Grade and Yield Pathologic TNM Stage in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy
Background/Aim: The present study compared the prognostic value of the yield pathologic (yp) stage, tumor regression grade (TRG), and neoadjuvant rectal (NAR) score in patients with locally advanced rectal cancer (LARC) who received neoadjuvant chemoradiotherapy (nCRT). Patients and Methods: For the assessment of tumor regression, the Dworak grading system was used. The NAR score was calculated using the following equation: (5ypN–3[cT–ypT]+12)2÷9.61. Results: In univariate analysis, the NAR score and ypTNM stage were significantly associated with DFS [hazard ratio (HR)=2.514, p
Source: In Vivo - June 30, 2020 Category: Research Authors: BAEK, J. H., BAEK, D. W., KANG, B. W., KIM, H. J., PARK, S. Y., PARK, J. S., CHOI, G. S., KIM, J. G. Tags: Clinical Studies Source Type: research

Laparoscopic Total Gastrectomy for Remnant Gastric Cancer: A Single-institution Experience and Systematic Literature Review
Conclusion: Laparoscopic total gastrectomy is a feasible surgical option for RGC. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: OTA, M., IKEBE, M., SHIN, Y., KAGAWA, M., MANO, Y., NAKANOKO, T., NAKASHIMA, Y., UEHARA, H., SUGIYAMA, M., IGUCHI, T., SUGIMACHI, K., YAMAMOTO, M., MORITA, M., TOH, Y. Tags: Clinical Studies Source Type: research

Volume Delineation in Cervical Cancer With T2 and Diffusion-weighted MRI: Agreement on Volumes Between Observers
Conclusion: GTV delineation was smaller in the ADC maps compared to T2-MRI, reaching an almost perfect agreement between observers. Thanks to this acceptable variability, adding functional imaging might provide more information for tumor delineation, improving reproducibility for image-guided adaptive radiotherapy. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: ROSA, C., PIZZI, A. D., AUGURIO, A., CARAVATTA, L., DI TOMMASO, M., MINCUZZI, E., CINALLI, S., BASILICO, R., PORRECA, A., DI NICOLA, M., GENOVESI, D. Tags: Clinical Studies Source Type: research

Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis
Background/Aim: Few studies have examined the prognostic significance of histological subtypes in patients with soft tissue sarcoma (STS) and distant metastasis, and we evaluated the relationship between the histological subtypes and clinical outcomes. Patients and Methods: This retrospective study evaluated the histological subtypes of 105 patients with STS and distant metastasis. The STS histological subtypes were compared based on the clinical information. Results: The Kaplan-Meier curves for overall survival revealed that myxoid liposarcoma had a significantly better prognosis compared to Malignant Peripheral Nerve She...
Source: In Vivo - June 30, 2020 Category: Research Authors: TSUCHIE, H., EMORI, M., MIYAKOSHI, N., NAGASAWA, H., OKADA, K., MURAHASHI, Y., MIZUSHIMA, E., SHIMIZU, J., YAMASHITA, T., SHIMADA, Y. Tags: Clinical Studies Source Type: research

Histopathological Features and Ann Arbor Stage in Periocular Lymphoma
Conclusion: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: ZSCHOCHE, M., ZIMPFER, A., SCHEEF, B. O., JUNEMANN, A. M., GUTHOFF, R. F., JUNGHANSS, C., HILDEBRANDT, G., EMMERT, S., ERBERSDOBLER, A., KUNDT, G., KAKKASSERY, V. Tags: Clinical Studies Source Type: research

Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase
Conclusion: Endometrial maturation requires 8 days, rather than the expected 6 days, to reach the histological mid-secretory phase. This is not a delay and is also seen in fertile patients. The new analysis method used is superior to that using Noyes criteria alone and provides a better basis for determining conditions for optimal timing of embryo transfers. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: ALFER, J., FATTAHI, A., BLEISINGER, N., KRIEG, J., BEHRENS, R., DITTRICH, R., BECKMANN, M. W., HARTMANN, A., CLASSEN-LINKE, I., POPOVICI, R. M. Tags: Clinical Studies Source Type: research

Impact of Antiplatelet and Anticoagulant Therapies on Platelet-related Prognostic Markers in Patients With Esophageal Cancer
Background/Aim: In recent years, platelet-related markers were recognized as useful prognostic factors in various malignancies. We investigated the relationship between platelet-related prognostic markers and anti-platelet or anti-coagulant therapies for survival outcomes in esophageal squamous cell carcinoma. Patients and Methods: Preoperative platelet-related prognostic markers were evaluated from peripheral blood testing and statistical analyses were performed to evaluate the prognostic value of these markers and reveal the effects of antiplatelets and/or anticoagulants regarding their prognostic relevance. Results: In ...
Source: In Vivo - June 30, 2020 Category: Research Authors: ISHIBASHI, Y., TSUJIMOTO, H., KOUZU, K., ITAZAKI, Y., TSUCHIYA, S., FUJISHIMA, S., YAGUCHI, Y., SUGASAWA, H., NOMURA, S., ITO, N., HARADA, M., NAGATA, H., SHINTO, E., KISHI, Y., UENO, H. Tags: Clinical Studies Source Type: research

Preoperative Nutritional Assessment Using the Controlling Nutritional Status Score to Predict Pancreatic Fistula After Pancreaticoduodenectomy
Conclusion: Patients with high CONUT score are at high risk for POPF. Preoperative nutritional intervention such as immunonutrition might help reduce the POPF risk in these patients. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: UTSUMI, M., AOKI, H., NAGAHISA, S., NISHIMURA, S., UNE, Y., KIMURA, Y., TANIGUCHI, F., ARATA, T., KATSUDA, K., TANAKAYA, K. Tags: Clinical Studies Source Type: research

Glasgow Prognostic Score (GPS) and Tumor Response as Biomarkers of Nivolumab Monotherapy in Third- or Later-line Setting for Advanced Gastric Cancer
Conclusion: We present the potential of GPS and DCBC as efficient biomarkers of nivolumab for AGC, that warrants further evaluation. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KUROSAKI, T., KAWAKAMI, H., MITANI, S., KAWABATA, R., TAKAHAMA, T., NONAGASE, Y., FUMITA, S., OZAKI, T., CHIBA, Y., TAMURA, T., NAKAGAWA, K. Tags: Clinical Studies Source Type: research

Treatment Outcome of Resection of Disseminated Peritoneal Metastases from Colorectal Cancer
Conclusion: More than a few cases of colorectal peritoneal metastasis, which is thought to be difficult to cure, were cured by resection of disseminated nodules without resorting to highly invasive treatment. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: OHIRA, G., MIYAUCHI, H., HAYANO, K., MARUYAMA, M., IMANISHI, S., TOCHIGI, T., MARUYAMA, T., HANAOKA, T., OKADA, K., MATSUBARA, H. Tags: Clinical Studies Source Type: research

Survival After Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiotherapy (FSRT) for Cerebral Metastases in the Elderly
Background/Aim: Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) have gained popularity especially for treating 1-3 cerebral metastases. Elderly patients benefit from treatment personalisation. A specific survival score was created to facilitate this approach. Patients and Methods: Ten characteristics were retrospectively analysed for survival in 104 elderly patients with 1-3 cerebral metastases receiving SRS or FSRT alone using a linear accelerator or Cyberknife®. Results: On multivariate analysis, better survival was significantly associated with KPS of 90-100 (p=0.049), single lesion...
Source: In Vivo - June 30, 2020 Category: Research Authors: RADES, D., NGUYEN, T., BLANCK, O., SCHILD, S. E. Tags: Clinical Studies Source Type: research

Preoperative C-Reactive Protein/Albumin Ratio as a Predictive Factor for Gallbladder Carcinoma
Background/Aim: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection. Patients and Methods: Fifty-three patients who underwent surgical resection for GBC between January 2008 and September 2019 were enrolled. We retrospectively investigated the relation between preoperative CAR and overall and disease-free survival. Results: The optimal cut-off CAR was 0.07. Multivariate analysis showed that i) R1 or R2 resection (p=0.033), ii) advanced tumor stage...
Source: In Vivo - June 30, 2020 Category: Research Authors: UTSUMI, M., AOKI, H., NAGAHISA, S., NISHIMURA, S., UNE, Y., KIMURA, Y., WATANABE, M., TANIGUCHI, F., ARATA, T., KATSUDA, K., TANAKAYA, K. Tags: Clinical Studies Source Type: research

The ABO Blood Group Impacts the Survival of Patients Undergoing Pancreatoduodenectomy for Biliary Tract Cancer
Conclusion: ABO blood group is associated with the prognosis of patients with resected BTC; group O patients have a better outcome. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: MORI, S., AOKI, T., TAGO, K., SHIMIZU, T., HARADA, N., PARK, K.-H., SAKURAOKA, Y., SHIRAKI, T., ISO, Y., KUBOTA, K. Tags: Clinical Studies Source Type: research

Salvage Photon or Proton Radiotherapy for Oligo-recurrence in Regional Lymph Nodes After Surgery for Non-small Cell Lung Cancer
Conclusion: Salvage RT is an effective treatment for NSCLC patients with oligo-recurrence at regional lymph nodes. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: NAKAMURA, M., OHNISHI, K., ISHIKAWA, H., NAKAZAWA, K., SHIOZAWA, T., OKUMURA, T., SEKINE, I., SATO, Y., HIZAWA, N., SAKURAI, H. Tags: Clinical Studies Source Type: research

Radiological and Histopathological Features of Internal Tooth Resorption
Conclusion: Our analyses demonstrate that internal root resorption is a multifaceted dental disease with considerable variability in the rate of the underlying inflammatory changes. Oral surgeons should take this into consideration when evaluating the need for extraction of teeth with internal root resorption. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KOEHNE, T., ZUSTIN, J., AMLING, M., FRIEDRICH, R. E. Tags: Clinical Studies Source Type: research

Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis
Conclusion: T-TAS is useful in the assessment of thrombogenesis in MMPs and HMGB1 is associated with thrombus formation. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KAKE, S., KAWAGUCHI, H., NAGASATO, T., YAMADA, T., ITO, T., MARUYAMA, I., MIURA, N., TANIMOTO, A. Tags: Experimental Studies Source Type: research

Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy
Conclusion: Changes in the uterine connexin 26 and connexin 43 expression by testosterone could disrupt embryo implantation, resulting in early pregnancy loss. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: KAMAL, D. A. M., IBRAHIM, S. F., MOKHTAR, M. H. Tags: Experimental Studies Source Type: research

Osteogenic Evaluation of Hydroxyapatite Scaffold Loaded With Dexamethasone in Femoral Drill Holes
Conclusion: DM-loaded HA scaffolds are suitable platforms for distributing bioactive molecules during osteogenesis in femoral drill holes. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: PARK, M.-H., JANG, S. J., CHOI, S. H. Tags: Experimental Studies Source Type: research

Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice
Conclusion: Combination of MH-30 with cisplatin may be a beneficial anticancer treatment with reduced adverse effects. (Source: In Vivo)
Source: In Vivo - June 30, 2020 Category: Research Authors: PARK, H.-R., JO, S.-K., CHO, H.-H., JUNG, U. Tags: Experimental Studies Source Type: research