Outcomes of Triple-Combination Therapy for Chronic Tinnitus
Conclusion: Triple-combination therapy could be helpful for chronic tinnitus patients. It seemed that coffee and tea consumption may elicit increased improvement in conjunction with combined therapy for chronic tinnitus. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: JUAN, Y.-H., HSU, C.-T., HWANG, J.-H. Tags: Clinical Studies Source Type: research

Correlation of Cerebroplacental Ratio (CPR) With Adverse Perinatal Outcome in Singleton Pregnancies
Background/Aim: For many years clinical research has been concerned with doppler sonography as a non-invasive tool for intrauterine fetal status assessment. A new focus is now placed on the measurement of cerebroplacental index (CPR) as a predictor of fetal outcome. Our aim was to investigate the relationship between the cerebroplacental ratio (CPR), the delivery mode and the fetal outcome in singleton pregnancies. Patients and Methods: A retrospective cohort study of pregnancies in which doppler sonography of middle cerebral artery (MCA) and umbilical artery (UA) was conducted up to 9 weeks before delivery took place. Pat...
Source: In Vivo - August 30, 2019 Category: Research Authors: GRUTTNER, B., RATIU, J., RATIU, D., GOTTSCHALK, I., MORGENSTERN, B., ABEL, J. S., EICHLER, C., PAHMEYER, C., LUDWIG, S., MALLMANN, P., THANGARAJAH, F. Tags: Clinical Studies Source Type: research

Extrahepatic Portal Venous Obstruction With Hepatic Enzyme Elevation Resembling Hepatitis in Patients With Cancer
Conclusion: EHPVO occurred in patients with metastatic cancer, leading to hepatic enzyme elevation resembling hepatitis without hepatitis risk factors and cirrhosis. Before withholding chemotherapy due to hepatic enzyme elevation, the possibility of EHPVO should firstly be excluded. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: LIAO, T.-Y., LIAW, C.-C., HSU, H.-C., HSIEH, C.-H., CHANG, J. W.-C., JUAN, Y.-H. Tags: Clinical Studies Source Type: research

Increasing Age Hinders the Decline in B-Type Natriuretic Peptide Following Parathyroidectomy in Dialysis Patients
Conclusion: The serum BNP levels may increase or decrease after parathyroidectomy. Younger age and lower symptom burden are associated with decline in BNP levels. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: CHU, T.-P., YANG, P.-S., LEE, J.-J., WU, C.-J., CHENG, S.-P. Tags: Clinical Studies Source Type: research

C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus
This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level. Materials and Methods: In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured. Results: Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with early- and those with late-onset. T2DM Hi...
Source: In Vivo - August 30, 2019 Category: Research Authors: HUANG, Y.-C., CHEN, C.-C., WANG, T.-Y., NGUYEN, H. T. T., CHEN, Y.-H., WU, C.-M., CHANG, Y.-W., LIAO, W.-L., TSAI, F.-J. Tags: Clinical Studies Source Type: research

Radiation Therapy for Uterine Cervical Cancer With Lung Metastases Including Oligometastases
Background/Aim: To investigate the role and outcomes of radiation therapy (RT) for stage IVB uterine cervical cancer (UCC) patients with lung (oligo) metastases due to the lack of recent reports on the subject. Patients and Methods: The cohort for this retrospective study comprised 23 consecutive patients with UCC (squamous cell carcinoma, n=13) and lung metastases who had received pelvic RT. Ten had lung metastases only, including 7 with oligometastases (≤4 lung metastases); the remaining 13 also had other distant metastases. Results: Nine (39.1%) of the 22 patients (95.7%) completed RT without interruption. The 1-year...
Source: In Vivo - August 30, 2019 Category: Research Authors: MUKAI, Y., KOIKE, I., MATSUNAGA, T., YOKOTA, N. R., TAKANO, S., SUGIURA, M., SATO, M., MIYAGI, E., HATA, M. Tags: Clinical Studies Source Type: research

Integrated Treatment With Stapled Haemorrhoidopexy and Proctonorm(R) of Haemorrhoidal Disease
Conclusion: The specific target activity of Proctonorm® at the microcircular level may be effective in patients undergoing SH in order to reduce the inflammatory response of residual haemorrhoids while waiting for stable resolution of symptoms within one or two weeks. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: REBOA, G., GIPPONI, M., FREGATTI, P., DEPAOLI, F. Tags: Clinical Studies Source Type: research

Aggressive Merkel Cell Carcinoma After Janus Kinase Inhibitor Ruxolitinib for Polycythemia Vera
This report shows the possibility of development of MCC in patients treated with ruxolitinib. Periodic skin examination is indicated in patients who undergo ruxolitinib therapy, especially if they have a history of skin cancer; dermatologists and oncohematologists should be aware of this possibility in order to introduce appropriate preventive strategies. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: RASTRELLI, M., FERRAZZI, B., TROPEA, S., COSTA, A., FINOTTO, S., MARINO, D., CAMPANA, L., DEL FIORE, P., ROSSI, C. R., ALAIBAC, M. Tags: Clinical Studies Source Type: research

Local Radiotherapy or Chemotherapy for Oligo-recurrent Cervical Cancer in Patients With Prior Pelvic Irradiation
Conclusion: Out-field oligo-recurrence in patients with initial early FIGO stages may be an indication of salvage radiotherapy. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: KOBAYASHI, K., MURAKAMI, N., TAKAHASHI, K., INABA, K., HAMAMOTO, R., ITAMI, J. Tags: Clinical Studies Source Type: research

Plasma Histone H4 and H4K20 Trimethylation Levels Differ Between Colon Cancer and Precancerous Polyps
Background/Aim: No blood-based biomarkers are available to differentiate between colonic tumors and precancerous polyps. Previously we demonstrated levels of trimethylated H4K20 (H4K20me3) to be lower in blood plasma from patients with colon cancer than those from cancer-free individuals. Herein, we added individuals with precancerous polyps for the first time in order to analyze and investigate the usefulness of plasma H4K20me3 and histone H4 to discriminate colon tumors from precancerous polyps. Materials and Methods: The study included a cohort of 185 individuals undergoing colonoscopy. H4K20me3 and histone H4, measured...
Source: In Vivo - August 30, 2019 Category: Research Authors: OZGUR, E., KESKIN, M., YORUKER, E. E., HOLDENRIEDER, S., GEZER, U. Tags: Clinical Studies Source Type: research

Phase Angle as an Objective and Predictive Factor of Radiotherapy-induced Changes in Body Composition of Male Patients With Head and Neck Cancer
Conclusion: PA prior to RT is a useful marker for selection of individuals with HNC who are at a high risk of unfavorable changes in body composition. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: MAŁECKA-MASSALSKA, T., POWROZEK, T., PRENDECKA, M., MLAK, R., SOBIESZEK, G., BRZOZOWSKI, W., BRZOZOWSKA, A. Tags: Clinical Studies Source Type: research

An Open-label, Single-arm Study of CRYO2 for Debulking at the Site of Central Airway Obstruction or Stenosis
Conclusion: CRYO2 for debulking at the site of obstruction or stenosis can be performed safely. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: SAKA, H., OKI, M., KADA, A., SAITO, A. M. Tags: Clinical Studies Source Type: research

Strain Ultrasound Elastography in the Achilles Tendon of Ankylosing Spondylitis Patients Treated With Anti-TNF-{alpha}: A Preliminary Study
Conclusion: AS patients had an Achilles tendon thickness greater than controls at the middle third, but no difference in the stiffness was found among them. Strain ultrasound elastography may be useful to exclude early changes in mechanical properties of tendons. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: ZARDI, E. M., PIPITA, M. E., GIORGI, C., AFELTRA, A., MAFFULLI, N., FRANCESCHI, F. Tags: Clinical Studies Source Type: research

Integrated IT Platform for Coordination of Diagnosis, Treatment, and Aftercare of Prosthetic Joint Infections
Conclusion: Using the developed tool enables the infections team to work collaboratively and under division of labor on each case, rendering the work flow more efficient for each team member. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: SUREN, C., FEIHL, S., QUERBACH, C., RAMER, P., POHLIG, F., THURNER, J., BERNARD, R., BUSCH, D., VON EISENHART-ROTHE, R., MUHLHOFER, H. M. L. Tags: Clinical Studies Source Type: research

Hypofractionated Accelerated Chemo-radiotherapy (Chemo-HypoAR) With Cisplatin and Liposomal Doxorubicin for the Treatment of Patients With Uterine Sarcomas
Conclusion: Concurrent hypofractionated and accelerated chemo-radiotherapy (chemo-HypoAR) is feasible and provides excellent survival figures. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: DOMOXOUDIS, S., KOUKOURAKIS, I. M., GIAKZIDIS, A. G., KOUKOURAKIS, M. I. Tags: Clinical Studies Source Type: research

Circulating Tumor Cell Counts in Patients With Localized Prostate Cancer Including Those Under Active Surveillance
Aim: To evaluate the clinical efficacy of a circulating tumor cell (CTC) test by comparison between healthy volunteers and patients with localized prostate cancer including those under active surveillance. Materials and Methods: CTC counts in peripheral blood were compared between patients with prostate cancer (n=45) and healthy volunteers (n=17). CTCs were identified based on the expression of epithelial cell adhesion molecule (EpCAM) and counted using a SMART BIOPSY™ SYSTEM. Results: The number of EpCAM+ cells was significantly higher in patients with cancer than in healthy volunteers. Among the low-risk patients (...
Source: In Vivo - August 30, 2019 Category: Research Authors: CHOI, S. Y., LIM, B., KYUNG, Y. S., KIM, Y., KIM, B. M., JEON, B. H., PARK, J. C., SOHN, Y. W., LEE, J. H., UH, J.-H., JANG, S., KIM, C.-S. Tags: Clinical Studies Source Type: research

Retrospective Analysis of Trabectedin Therapy for Soft Tissue Sarcoma
Conclusion: Trabectedin 1.2 mg/m2, as the approved dose in Japan, showed similar efficacy to the dose of 1.5 mg/m2 used in Western countries. Trabectedin could be an option for advanced STS in Japan, regardless of histological subtype. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: KAWAGUCHI, K., NAKANO, K., URASAKI, T., FUKUDA, N., TAIRA, S., ONO, M., TOMOMATSU, J., NISHIZAWA, M., AE, K., MATSUMOTO, S., TAKAHASHI, S. Tags: Clinical Studies Source Type: research

Surgical Resection of Colorectal Cancer With Distant Metastases to Other than Liver or Lung
Conclusion: Curative surgical resection appears to be useful for distant CRC metastases to organs other than liver or lung. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: NAITO, A., KAGAWA, Y., KAWAI, K., TAKENO, A., TAKEDA, Y., OHTSUKA, M., SUZUKI, Y., IMASATO, M., FUJIE, Y., NAKABA, H., AKAMATSU, H., MURATA, K. Tags: Clinical Studies Source Type: research

Methotrexate-associated Classical Hodgkin Lymphoma Shows Distinct Clinicopathological Features but Comparable Clinical Outcomes With Sporadic Cases
Conclusion: The present study revealed differences in clinicopathological features but similarities in clinical outcomes of MTX-CHL and sporadic CHL. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: YOSHIFUJI, K., UMEZAWA, Y., ICHIKAWA, A., WATANABE, K., MIURA, O., YAMAMOTO, M. Tags: Clinical Studies Source Type: research

Successful Management of a Pregnant Patient With Chronic Myeloid Leukemia Receiving Standard Dose Imatinib
Conclusion: Our case report demonstrates that, if the pregnancy is properly planned in CML patients, it can result in excellent management of the clinical therapeutic option for the benefit of both mother and child. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: STELLA, S., TIRRO, E., MASSIMINO, M., VITALE, S. R., RUSSO, S., PENNISI, M. S., PUMA, A., ROMANO, C., DI GREGORIO, S., INNAO, V., STAGNO, F., DI RAIMONDO, F., MUSOLINO, C., MANZELLA, L. Tags: Clinical Studies Source Type: research

Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure
Conclusion: High GRP78 serum concentration may protect the patient from ER stress. In addition, the serum PERK level is high in patients with HF, whereas it is insufficient in predicting acute decompensation. CHOP may be useful in predicting the length of hospital stay in patients with ADHF. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: SABIRLI, R., KOSELER, A., MANSUR, N., ZEYTUNLUOGLU, A., SABIRLI, G. T., TURKCUER, I., KILIC, I. D. Tags: Clinical Studies Source Type: research

Predictive Value of Osteoprotegerin and Neutrophil Gelatinase-associated Lipocalin on Multiple Organ Failure in Multiple Trauma
Conclusion: NGAL and OPG might be indicative of MODS and could have the potential to be biomarkers in the early detection of patients at risk of posttraumatic MODS. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: PETERS, H., MACKE, C., MOMMSEN, P., ZECKEY, C., CLAUSEN, J.-D., KRETTEK, C., NEUNABER, C., WINKELMANN, M. Tags: Clinical Studies Source Type: research

Overview and Comparison of Infectious Endocarditis and Non-infectious Endocarditis: A Review of 814 Autoptic Cases
Conclusion: In general, we found several data that differ from those generally present in the scientific literature, and this could be explained by the fact that data on IE and NIE are generally obtained from surgical and clinical databases, while we analysed only autoptic cases. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: BUSSANI, R., DE-GIORGIO, F., PESEL, G., ZANDONA, L., SINAGRA, G., GRASSI, S., BALDI, A., ABBATE, A., SILVESTRI, F. Tags: Clinical Studies Source Type: research

First Reported Use of the Faxitron LOCalizer™ Radiofrequency Identification (RFID) System in Europe - A Feasibility Trial, Surgical Guide and Review for Non-palpable Breast Lesions
Conclusion: This trial added a small number of consecutively recruited patients to an existing number of available data, resulting in a total of 121 evaluated and reviewed Faxitron LOCalizer™ marked non-palpable in-breast lesions worldwide. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: MALTER, W., HOLTSCHMIDT, J., THANGARAJAH, F., MALLMANN, P., KRUG, B., WARM, M., EICHLER, C. Tags: Clinical Studies Source Type: research

Impact of Bile Exposure Time on Organ/space Surgical Site Infections After Pancreaticoduodenectomy
Conclusion: Long BE time is a risk factor for post-pancreaticoduodenectomy organ/space SSIs. Shortening BE time may reduce organ/space SSI occurrence. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: KUMAGAI, Y., FUJIOKA, S., HATA, T., MISAWA, T., KITAMURA, H., FURUKAWA, K., ISHIDA, Y., YANAGA, K. Tags: Clinical Studies Source Type: research

Artificial Intelligence in Obstetrics and Gynaecology: Is This the Way Forward?
An increasing trend in funding towards artificial intelligence (AI) research in medicine has re-animated huge expectations for future applications. Obstetrics and gynaecology remain highly litigious specialities, accounting for a large proportion of indemnity payments due to poor outcomes. Several challenges have to be faced in order to improve current clinical practice in both obstetrics and gynaecology. For instance, a complete understanding of fetal physiology and establishing accurately predictive antepartum and intrapartum monitoring are yet to be achieved. In gynaecology, the complexity of molecular biology results i...
Source: In Vivo - August 30, 2019 Category: Research Authors: EMIN, E. I., EMIN, E., PAPALOIS, A., WILLMOTT, F., CLARKE, S., SIDERIS, M. Tags: Clinical Studies Source Type: research

Impact of Accidental Hypothermia on Pulmonary Complications in Multiply Injured Patients With Blunt Chest Trauma - A Matched-pair Analysis
The objective of this study was to analyze the influence of accidental hypothermia on pulmonary complications in multiply injured patients with blunt chest trauma. Patients and Methods: Multiply injured patients [injury severity score (ISS) ≥16] with severe blunt chest trauma [abbreviated injury scale of the chest (AISchest) ≥3] were analyzed. Hypothermia was defined as body core temperature
Source: In Vivo - August 30, 2019 Category: Research Authors: WINKELMANN, M., CLAUSEN, J.-D., GRAEFF, P., SCHROTER, C., ZECKEY, C., WEBER-SPICKSCHEN, S., MOMMSEN, P. Tags: Clinical Studies Source Type: research

Pericardial Synovial Sarcoma: Case Report, Literature Review and Pooled Analysis
Conclusion: Only complete resection of the tumor seems to be an independent prognostic factor. To our knowledge, this is the first report on the safety and effectivity of pazopanib in PSS and may provide guidance for similar cases in the future. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: DURAN-MORENO, J., KAMPOLI, K., KAPETANAKIS, E. I., MADEMLI, M., KOUFOPOULOS, N., FOUKAS, P. G., KOSTOPANAGIOTOU, K., TOMOS, P., KOUMARIANOU, A. Tags: Clinical Studies Source Type: research

Quality Indicators and Survival Outcome in Stage IIIB-IVB Epithelial Ovarian Cancer Treated at a Single Institution
Conclusion: Patient age, tumor stage and complete tumor removal at surgery were significant, independent prognostic factors of overall survival. Complication rate was a significant adverse prognostic factor in univariate analysis. Data discrepancy was observed between public quality reports and locally obtained data. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: STEINBERGA, I., JANSSON, K., SORBE, B. Tags: Clinical Studies Source Type: research

Acute and 28-Day Repeated Inhalation Toxicity Study of Glycolic Acid in Male Sprague-Dawley Rats
Conclusion: The No Observed Adverse Effect Concentration (NOAEC) for the nasal and pulmonary toxicity of glycolic acid was determined to be over 50 mg/m3 at the end of a 28-day inhalation test in male rats. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: LIM, S. K., YOO, J., KIM, H., KIM, W., SHIM, I., YOON, B.-I., KIM, P., DO YU, S., EOM, I.-C. Tags: Experimental Studies Source Type: research

The Role of Fgf Signaling on Epithelial Cell Differentiation in Mouse Vagina
Conclusion: FGF-ERK/MAPK pathway may be a main inducer of terminal differentiation in the mouse vaginal epithelium. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: HIRANO, Y., SUZUKI, K., IGUCHI, T., YAMADA, G., MIYAGAWA, S. Tags: Experimental Studies Source Type: research

Enhanced NLRP3 and DEFA1B Expression During the Active Stage of Parenchymal Neuro-Behcet's Disease
Conclusion: Immunological factors showing the most significant increase in expression during NBD attacks were primarily associated with innate immunity functions. DEFA1B and NLRP3 can be used as biomarkers for estimation of disease activity in NBD. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: UGUREL, E., ERDAG, E., KUCUKALI, C. I., OLCAY, A., SANLI, E., AKBAYIR, E., KURTUNCU, M., GUNDUZ, T., YILMAZ, V., TUZUN, E., VURAL, B. Tags: Experimental Studies Source Type: research

Targeted Sequencing of Tubo-ovarian and Peritoneal High-grade Serous Carcinoma With Wild-type p53 Immunostaining Pattern
Conclusion: HGSCs exhibit TP53 mutations even though a subset of HGSCs displayed a wild-type p53 immunostaining pattern. Chemotherapy does not affect the TP53 mutational status in HGSC. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: KIM, H.-N., WOO, H. Y., DO, S.-I., KIM, H.-S. Tags: Experimental Studies Source Type: research

Intra-vital Observation of Lung Water Retention Following Intravenous Injection of Anti-MHC-class I (H-2K) Monoclonal Antibody in Mice
Conclusion: Pulmonary edema develops rapidly following leukocyte accumulation in the lung. We confirmed that leukocyte accumulation without an underlining condition is sufficient to induce pulmonary edema. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: OCHI, H., IIJIMA, T., USHIYAMA, A. Tags: Experimental Studies Source Type: research

Impact of Bevacizumab on Liver Damage After Massive Hepatectomy in Rats
Background: The aim of this study was to evaluate the impact of pretreatment with bevacizumab on liver damage in a rat model of massive hepatectomy (Hx) model, as a surrogate model of massive Hx for liver metastasis from colorectal cancer. Materials and Methods: Male Wister rats (n=24) were separated into the following two groups: 90% Hx and 90% Hx plus bevacizumab group. Bevacizumab (5 mg/kg) was injected intraperitoneally 7 days before Hx. Samples of blood and remnant liver tissue were obtained 24 hours after hepatectomy and the following parameters were evaluated: Biochemical analysis; liver regeneration rate; survival ...
Source: In Vivo - August 30, 2019 Category: Research Authors: MORI, H., SAITO, Y., IWAHASHI, S., IKEMOTO, T., IMURA, S., MORINE, Y., SHIMADA, M. Tags: Experimental Studies Source Type: research

Shining a Light on the Effects of the Combination of (-)-Epigallocatechin-3-gallate and Tapentadol on the Growth of Human Triple-negative Breast Cancer Cells
Background/Aim: Breast cancer is characterized by a high rate of mortality and is considered one of the deadliest types of cancer. It is of note that (–)-epigallocatechin-3-gallate (EGCG), the principal catechin of green tea, is able to hinder the growth of MDA-MB-231 breast cancer cells by influencing different signaling pathways, including apoptosis. Furthermore, EGCG is also used in the treatment of bone cancer pain. Tapentadol, an opioid drug acting at the level of noradrenaline (norepinephrine) reuptake inhibition and μ-opioid receptor, is able to modulate bone cancer pain and influence cancer cell viability ...
Source: In Vivo - August 30, 2019 Category: Research Authors: BIMONTE, S., CASCELLA, M., BARBIERI, A., ARRA, C., CUOMO, A. Tags: Experimental Studies Source Type: research

Oral Administration of Chitosan Attenuates Bleomycin-induced Pulmonary Fibrosis in Rats
Conclusion: This study revealed that oral chitosan exhibits potential antifibrotic effects, as measured by decreased proinflammatory cytokine levels and histological evaluation, in a BLM-induced PF rat model. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: KIM, Y.-S., LI, Q., YOUN, H.-Y., KIM, D. Y. Tags: Experimental Studies Source Type: research

Evaluation of Biocompatibility of Different Membrane Surfaces Using Unrestricted Somatic Stem Cells
Conclusion: This study shows that USSCs can be used for assessments of biocompatibility, and that absorbable membranes with collagenous composition and porous structure tend to positively impact biocompatibility and enhance cell proliferation. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: SCHORN, L., HANDSCHEL, J., LOMMEN, J., VON BECK, F. P., DEPPRICH, R., KUBLER, N., HOLTMANN, H. Tags: Experimental Studies Source Type: research

Estrogen Down-regulator Fulvestrant Potentiates Antitumor Activity of Fluoropyrimidine in Estrogen-responsive MCF-7 Human Breast Cancer Cells
Background: Endocrine therapy is clinically administered in hormone-responsive breast cancer. Combinations of fluoropyrimidine S-1 and an aromatase inhibitor or anti-estrogen are considered beneficial in Japan. Herein we assessed new combinations of S-1 and fulvestrant. Patients and Methods: Cytotoxicity of fulvestrant and 5-fluorouracil (5-FU) was assessed in hormone-responsive (MCF-7) and non-responsive (MDA-MB-231) breast cancer cell cultures. Fulvestrant and S-1 were evaluated for antitumor activity in mice and their effects on estrogen receptor (ER)-α and progesterone receptor (PgR) levels in MCF-7 xenografts us...
Source: In Vivo - August 30, 2019 Category: Research Authors: NUKATSUKA, M., SAITO, H., NOGUCHI, S., TAKECHI, T. Tags: Experimental Studies Source Type: research

TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides
Conclusion: TRPV1 mediates glucose-induced insulin secretion likely through CGRP and SP release. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: ZHONG, B., MA, S., WANG, D. H. Tags: Experimental Studies Source Type: research

Pneumococcal Vaccination Strategies Among HIV-infected Adult Patients: A Review of the Literature
Conclusion: Further studies are needed to determine the optimal vaccines and intervals for subsequent revaccinations during the lifetime. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: GARMPI, A., DAMASKOS, C., GARMPIS, N., PATSOURAS, A., SAVVANIS, S., GRAVVANIS, N., DIAMANTIS, E. Tags: Reviews Source Type: research

Bisphenol A: A Concise Review of Literature and a Discussion of Health and Regulatory Implications
Conclusion: Recent evidence suggests that low-doses of endocrine disruptors, such as BPA, could have profound effects in breast development and cancer risk. Recent studies in murine models suggest that BPA could contribute to breast oncogenesis via several pathways. The position of regulators should shift accordingly to safeguard the public interest. (Source: In Vivo)
Source: In Vivo - August 30, 2019 Category: Research Authors: WAZIR, U., MOKBEL, K. Tags: Reviews Source Type: research

A Review of Hepatocellular Carcinoma in Elderly Patients Focused on Management and Outcomes
Recent studies report a significant age-specific increase in hepatocellular carcinoma (HCC) development among persons over 75 years old. Therefore, there is an urgent need to determine the optimal treatment strategy in elderly patients with HCC. This systemic review examines the clinical characteristics, efficacy, and safety of first-line treatment modalities. The literature was searched regarding epidemiology and clinical outcomes in elderly patients (age ≥75 years) undergoing first-line treatment for HCC. Causative or comorbid conditions of HCC in elderly patients differed from those in younger patients. Radiofrequenc...
Source: In Vivo - August 30, 2019 Category: Research Authors: CHO, E., CHO, H. A., JUN, C. H., KIM, H. J., CHO, S. B., CHOI, S. K. Tags: Reviews Source Type: research

Optical Coherence Tomography of Choroid in Common Neurological Diseases
The choroid is involved directly and indirectly in many pathological conditions such as age-related macular degeneration, myopia-related chorioretinal atrophy and central serous chorioretinopathy. Optical coherence tomography (OCT) has gradually become a fundamental part of modern resources in the hands of ophthalmologists. The enhanced depth imaging technique and swept-source OCT make a great contribution to conventional in vivo choroid assessment. This review focuses on the most common neurological conditions in which choroid assessment by OCT may provide help in early diagnosis and be used as an interdisciplinary follow...
Source: In Vivo - August 30, 2019 Category: Research Authors: DI STASO, F., CIANCAGLINI, M., ABDOLRAHIMZADEH, S., D'APOLITO, F., SCUDERI, G. Tags: Reviews Source Type: research

Rethinking the Issue of Power Morcellation of Uterine Fibroids: Is Morcellation the Real Problem or Is this Another Symptom of Disparity in Healthcare Provision?
Power morcellation remains one of the most significant developments in minimal access surgery over the past decade, allowing many more patients to benefit from the least invasive surgical route. However, its use is not without controversy, particularly with regards to the risks of an undiagnosed leiomyosarcoma. Increased media and, in particular, on-going social media coverage since events in 2014 have only served to intensify the debate, culminating in the Food and Drug Administration essentially ‘banning’ its use in the USA. Practice however continues to vary and this technique remains widely used in Europe a...
Source: In Vivo - August 30, 2019 Category: Research Authors: ODEJINMI, F., AREF-ADIB, M., LIOU, N., SIDERIS, M., MALLICK, R. Tags: Reviews Source Type: research

Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy
Conclusion: No cognitive impairment was found during the two years of ET. Baseline cognitive scores and QOL dimensions proved good predictors of later anxiety and depression. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: BIRO, E., KAHAN, Z., KALMAN, J., RUSZ, O., PAKASKI, M., IRINYI, T., KELEMEN, G., DUDAS, R., DROTOS, G., HAMVAI, C. Tags: Clinical Studies Source Type: research

Post-thyroidectomy Hypocalcemia in Patients With History of Bariatric Operations: Current Evidence and Management Options
Conclusion: Patients with previous bariatric surgery are at high risk of post-thyroidectomy hypocalcemia that sometimes leads to higher length of hospital stay and demands more invasive solutions. There is a need, however, for additional studies and further investigation in order to reach more conclusive results. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: SPARTALIS, E., THANASSA, A., ATHANASIADIS, D. I., SCHIZAS, D., ATHANASIOU, A., ZOGRAFOS, G. N., TSOUROUFLIS, G., DIMITROULIS, D., NIKITEAS, N. Tags: Clinical Studies Source Type: research

Factors Associated With Distant Metastasis in EGFR-mutated Non-small Cell Lung Cancer Patients: Logistic Analysis
Conclusion: Knowing the factors associated with distant metastasis will provide useful information to conduct targeted and efficient imaging studies. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: WATANABE, H., OKAUCHI, S., MIYAZAKI, K., SATOH, H., HIZAWA, N. Tags: Clinical Studies Source Type: research

Chemoradiotherapy for Local Recurrence of Rectal Cancer: A Single Center Study of 18 Patients
Conclusion: CRT for local recurrence of rectal cancer without distant metastasis produces similar overall survival rates and local control as conventional surgical resection. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: WATANABE, J., SHOJI, H., HAMAGUCHI, T., MIYAMOTO, T., HIRANO, H., IWASA, S., HONMA, Y., TAKASHIMA, A., KATO, K., ITO, Y., ITAMI, J., KANEMITSU, Y., BOKU, N. Tags: Clinical Studies Source Type: research

Prophylactic Antiemetics for Haematological Malignancies: Prospective Nationwide Survey Subset Analysis in Japan
Conclusion: Guideline compliance was very low. Although not statistically significant, there was a trend for reduced CINV and improved disease control for triple versus double antiemetics, suggesting that triple antiemetics should be considered for HEC, especially in young female patients with non-Hodgkin lymphoma receiving CHOP-like regimens. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: YOSHIDA, I., TAMURA, K., MIYAMOTO, T., SHIMOKAWA, M., TAKAMATSU, Y., NANYA, Y., MATSUMURA, I., GOTOH, M., IGARASHI, T., TAKAHASHI, T., AIBA, K., KUMAGAI, K., ISHIZAWA, K., KURITA, N., USUI, N., HATAKE, K. Tags: Clinical Studies Source Type: research