Quality of Life of Patients With Cancer During the COVID-19 Pandemic
Background: The COVID-19 pandemic has changed the organisation of medical care. Patients and Methods: This is the first prospective observational study on patient-reported outcomes, quality of life (HRQOL) and satisfaction in patients with cancer with their care management in a day hospital during the period of May-June 2020. The Generalised Anxiety Disorder Screener and 12-Item Short-Form Health Survey were used. Results: The survey was completed by 189 of 267 patients. They were generally aged 61 to 70 years and women and presented with lung, breast, or colorectal cancer. Patients had low anxiety scores (mean: 3.2±...
Source: In Vivo - January 5, 2021 Category: Research Authors: BAFFERT, K.-A., DARBAS, T., LEBRUN-LY, V., PESTRE-MUNIER, J., PEYRAMAURE, C., DESCOURS, C., MONDOLY, M., LATROUITE, S., BIGNON, E., NICOULEAU, S., GEYL, S., LEOBON, S., DELUCHE, E. Tags: Articles on Covid-19 Source Type: research

Beneficial Effects of Intermediate Dosage of Anticoagulation Treatment on the Prognosis of Hospitalized COVID-19 Patients: The ETHRA Study
Conclusion: Anticoagulation treatment (particularly intermediate dosage) appears to have positive impact on COVID-19 inpatients’ prognosis by inhibiting both coagulation and inflammatory cascades. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: POULAKOU, G., DIMAKAKOS, E., KOLLIAS, A., KYRIAKOULIS, K. G., RAPTI, V., TRONTZAS, I., THANOS, C., ABDELRASOUL, M., VANTANA, T., LEONTIS, K., KAKALOU, E., ARGYRAKI, K., BARABOUTIS, I., MICHELAKIS, E., GIAMARELLOS-BOURBOULIS, E., DIMAKOU, K., TSOUKALAS, G. Tags: Articles on Covid-19 Source Type: research

Palliative Radiotherapy During the Last Month of Life: Have COVID-19 Recommendations Led to Reduced Utilization?
Conclusion: Rapid adoption of modified PRT regimens was feasible. However, the challenge of overtreatment in the final phase of the disease, due to inaccurate survival prediction, persisted. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NIEDER, C., HAUKLAND, E. C., MANNSAKER, B., YOBUTA, R. Tags: Articles on Covid-19 Source Type: research

The Impact of Peripheral Eosinophil Counts and Eosinophil to Lymphocyte Ratio (ELR) in the Clinical Course of COVID-19 Patients: A Retrospective Study
Background/Aim: Eosinophils are blood cells responsible for response against parasites and allergens. Eosinophil to lymphocyte ratio (ELR) is a biomarker for inflammatory conditions. Our aim was to evaluate the role of eosinophils and ELR in COVID-19 patients. Patients and Methods: The study included 96 patients hospitalized with COVID-19. They were classified into moderate to severe cases and critical cases. Eosinophils and ELR were determined in both groups, in patients that died or survived and were correlated to duration of hospitalization. Results: There was a statistically significant decrease in eosinophils and ELR ...
Source: In Vivo - January 5, 2021 Category: Research Authors: GEORGAKOPOULOU, V. E., GARMPIS, N., DAMASKOS, C., VALSAMI, S., DIMITROULIS, D., DIAMANTIS, E., FARMAKI, P., PAPAGEORGIOU, C. V., MAKRODIMITRI, S., GRAVVANIS, N., VELONIAS, S., SKLAPANI, P., TRAKAS, N., ANTONIOU, E. A., KONTZOGLOU, K., NIKOLIDAKIS, L., DAM Tags: Articles on Covid-19 Source Type: research

Breast Cancer Surgery in the COVID-19 Pandemic: Validation of a Preventive Program for Patients and Health Care Workers
Conclusion: This preventive program avoided any COVID-19 infection among patients and HCWs, so that an elective breast cancer surgical procedure can be safely and timely pursued without affecting the oncologic outcome. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: FREGATTI, P., GIPPONI, M., GIACCHINO, M., SPARAVIGNA, M., DIAZ, R., FIORAVANTI, E., CORNACCHIA, C., CONTE, B., LAMBERTINI, M., ZOPPOLI, G., MURELLI, F., TONI, M. L., CALABRO, M. T., ORSINO, L., FRIEDMAN, D. Tags: Articles on Covid-19 Source Type: research

Pulmonary Mucinous Cystadenoma - A Rare Pathology
Conclusion: Pulmonary mucinous cystadenoma is one of the primary pulmonary mucinous cystic neoplasia (PMCT) alongside PMCT of low malignancy and pulmonary mucinous cystadenocarcinoma (PMCAC). Because of this and because of the clinical and imagistic similarities between these main entities, establishing a preoperative diagnosis becomes very difficult. Therefore, histopathological and immunohistochemistry studies are mandatory in order to establish the correct diagnosis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: SAVU, C., MELINTE, A., GIBU, A., VARBAN, S., DIACONU, C., STIRU, O., BALESCU, I., BACALBASA, N. Tags: Clinical Studies Source Type: research

Repetitive Peripheral Magnetic Stimulation (rPMS) in Subjects With Lumbar Radiculopathy: An Electromyography-guided Prospective, Randomized Study
Conclusion: rPMS can constitute an effective treatment for subjects with lumbar radiculopathy and its association with a complex physical rehabilitation program could improve the outcome in these patients. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: SAVULESCU, S. E., BERTEANU, M., FILIPESCU, I., BEIU, C., MIHAI, M.-M., POPA, L. G., POPESCU, S. I., BALESCU, I., BACALBASA, N., POPESCU, M.-N. Tags: Clinical Studies Source Type: research

A Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Intermediated-risk Acute Myeloid Leukemia Patients
Conclusion: The outcome of alloSCT after relapse is not inferior to that of alloSCT in CR1, supporting the role of alloSCT after relapse in the setting of limited donors and resources. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: OH, M. J., SHIN, D.-Y., KOH, Y., HONG, J., KIM, I., YOON, S.-S., BYUN, J. M. Tags: Clinical Studies Source Type: research

Clinical Outcome of Dermatofibrosarcoma Protuberance. Report From the Bone and Soft Tissue Tumor (BSTT) Registry in Japan
Conclusion: If UE is performed, we recommend additional excision for preventing local recurrence; however, the surgical wound should be carefully observed. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKAMURA, T., KAWAI, A., ASANUMA, K., HAGI, T., SUDO, A. Tags: Clinical Studies Source Type: research

Low MLL2 Protein Expression Is Associated With Fibrosis in Early Stage Gastric Cancer
Conclusion: There is potentially an association between low expression of MLL2 protein and gastric malignancy from chronic fibrosis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NUMAKURA, S., UOZAKI, H. Tags: Clinical Studies Source Type: research

Impact of Fluoropyrimidine and Oxaliplatin-based Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer
Conclusion: The addition of OX to an FP regimen in neoadjuvant CRT for LARC may reduce local recurrence in patients who have achieved good compliance to CRT. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: OKADA, Y., OZAWA, T., HAYAMA, T., OHNO, K., TSUKAMOTO, M., FUKUSHIMA, Y., SHIMADA, R., NOZAWA, K., MATSUDA, K., HASHIGUCHI, Y. Tags: Clinical Studies Source Type: research

Clinical Spectrum and Outcomes of Neonatal Necrotizing Enterocolitis
Conclusion: We underline the value of both surgical and conservative approach with careful management in this cohort of patients. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: GAŁAZKA, P., CHRZANOWSKA, M., STYCZYNSKI, J. Tags: Clinical Studies Source Type: research

Customized 3D Bolus Applied to the Oral Cavity and Supraclavicular Area for Head and Neck Cancer
Conclusion: The customized 3D bolus enables effective skin sparing and full coverage of the target area. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: BAEK, S., AHN, S., JU, E., JUNG, N. H. Tags: Clinical Studies Source Type: research

Curative Radiotherapy in Elderly Patients With Muscle Invasive Bladder Cancer: The Prognostic Role of Sarcopenia
Conclusion: Sarcopenia cannot be considered a negative prognostic factor for MIBC elderly patients treated with external beam radiotherapy. Irradiation is therefore a feasible and effective choice for these patients, especially if unfit for surgery. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: FERINI, G., CACCIOLA, A., PARISI, S., LILLO, S., MOLINO, L., TAMBURELLA, C., DAVI, V., NAPOLI, I., PLATANIA, A., SETTINERI, N., IATI, G., PONTORIERO, A., PERGOLIZZI, S., SANTACATERINA, A. Tags: Clinical Studies Source Type: research

Effect of Prognostic Nutrition Index in Gastric or Gastro-oesophageal Junction Cancer Patients Undergoing Nivolumab Monotherapy
Background/Aim: We hypothesised that the prognostic nutrition index (PNI) is useful for evaluating host immunity and response to immune checkpoint inhibitors. We investigated the effect of PNI on nivolumab monotherapy efficacy in advanced or recurrent gastric cancer (GC) or gastro-oesophageal junction cancer (GOC) patients. Patients and Methods: We retrospectively examined 110 patients, divided them into a high-PNI group and a low-PNI group, and compared treatment efficacy, adverse events (AEs), and survival between the groups. Results: Median overall survival (OS) was significantly longer in the high-PNI group than in the...
Source: In Vivo - January 5, 2021 Category: Research Authors: WATANABE, H., YAMADA, T., KOMORI, K., HARA, K., KANO, K., TAKAHASHI, K., KUMAZU, Y., FUJIKAWA, H., NUMATA, M., AOYAMA, T., TAMAGAWA, H., INOKUCHI, Y., MACHIDA, N., SHIOZAWA, M., YUKAWA, N., MORINAGA, S., RINO, Y., MASUDA, M., OGATA, T., OSHIMA, T. Tags: Clinical Studies Source Type: research

Postoperative Complications Predict Long-term Outcome After Curative Resection for Perforated Colorectal Cancer
Conclusion: Postoperative complications were significantly associated with RFS and OS, and pT4 was associated with RFS. The prevention and management of postoperative adverse events may be important for perforated CRC. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: HASHIMOTO, S., HAMADA, K., SUMIDA, Y., ARAKI, M., WAKATA, K., KUGIYAMA, T., SHIBUYA, A., NISHIMUTA, M., MORINO, S., BABA, M., KIYA, S., OZEKI, K., NAKAMURA, A. Tags: Clinical Studies Source Type: research

Preoperative Octenidine Application in Breast Reconstruction Surgery
Conclusion: Preoperative washing protocols involving the Octenisan® wash lotion is relatively cheap and easy to follow. There is evidence that washing protocols result in a reduction of S. aureus infections leading to a better perioperative outcome. Octenisan® is safe to use in implant-based breast reconstructive surgery and is not associated with higher risks for patients. Our study did not yield any significant reduction in perioperative and postoperative complication and infection rates. This is attributed to a relatively low study population. Wash lotion compliance was only 48.7%. Proper patient education is cr...
Source: In Vivo - January 5, 2021 Category: Research Authors: HACHENBERG, J., ACIS, E., AUER-SCHMIDT, M. M., WARM, M., MALTER, W., THANGARAJAH, F., EICHLER, C. Tags: Clinical Studies Source Type: research

Identification of Salivary Proteomic Biomarkers for Oral Cancer Screening
Background/aim: The current study aimed to identify biomarkers for differentiating between patients with oral cancer (OC) and healthy controls (HCs) on the basis of the comprehensive proteomic analyses of saliva samples by using liquid chromatography-mass spectrometry (LC-MS/MS). Patients and Methods: Unstimulated saliva samples were collected from 39 patients with OC and from 31 HCs. Proteins in the saliva were comprehensively analyzed using LC-MS/MS. To differentiate between patients with OC and HCs, a multiple logistic regression model was developed for evaluating the discriminatory ability of a combination of multiple ...
Source: In Vivo - January 5, 2021 Category: Research Authors: ISHIKAWA, S., ISHIZAWA, K., TANAKA, A., KIMURA, H., KITABATAKE, K., SUGANO, A., EDAMATSU, K., UEDA, S., IINO, M. Tags: Clinical Studies Source Type: research

Pathological Examination of the Late Embryonic Heart Using the Same 4-chamber and 3-vessel Planes Used in Fetal Echocardiography
Conclusion: We consider our proposed pathologic examination protocol feasible for evaluating normal heart structures and ruling out severe congenital heart disease. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: HERGHELEGIU, C. G., NEACSU, A., CHIRCURESCU, R., HERGHELEGIU, D., VOINEA, S. C., DIACONU, C., STIRU, O., SAVU, C., FILIPESCU, A., BALESCU, I., BACALBASA, N., SUCIU, N. Tags: Clinical Studies Source Type: research

Impact of Lymphovascular Invasion in Patients With Stage II Colorectal Cancer: A Propensity Score-matched Study
Conclusion: In patients with stage II CRC, venous invasion proved to be a significant high-degree risk factor that may warrant adjuvant chemotherapy. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: KATAOKA, M., HIRANO, Y., ISHII, T., KONDO, H., ASARI, M., ISHIKAWA, S., KATAOKA, A., FUJII, T., SHIMAMURA, S., YAMAGUCHI, S. Tags: Clinical Studies Source Type: research

Management of Concomitant Abdominal Aortic Aneurysm and Intra-abdominal, Retroperitoneal Malignancy
Conclusion: Symptomatic disease must be resolved first. Two-stage procedures are the method of choice and offer better short-term results compared to one-stage procedures. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: TRESKA, V., MOLACEK, J., CERTIK, B., HOUDEK, K., HOSEK, P., SOUKUPOVA, V., STOGEROVA, C., SVEJDOVA, A. Tags: Clinical Studies Source Type: research

A Prognostic Score for Predicting Survival in Patients With Pancreatic Head Adenocarcinoma and Distal Cholangiocarcinoma
Conclusion: The PHT score may have a potential impact on predicting overall survival and consequently modulate the timing and type of treatment (up-front surgery vs. neoadjuvant therapy) patients are offered. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: MUTTILLO, E. M., CIARDI, A., SAULLO, P., TROIANO, R., MASSELLI, G., GUIDA, M., TORTORA, A., SPERDUTI, I., MARINELLO, G., CHIRLETTI, P., CARONNA, R. Tags: Clinical Studies Source Type: research

ATM Expression as a Prognostic Marker in Patients With Advanced Biliary Tract Cancer Treated With First-line Gemcitabine and Platinum Chemotherapy
Conclusion: We demonstrated that ATM loss could be a prognostic marker after platinum-based chemotherapy in patients with advanced EH-CCC. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: KIM, H., KIM, S. T., YOO, K. H., HONG, J. Y., PARK, Y. S., LIM, H. Y., PARK, J. O. Tags: Clinical Studies Source Type: research

Tensor Regression-based Model to Investigate Heterogeneous Spatial Radiosensitivity After I-125 Seed Implantation for Prostate Cancer
Conclusion: Our tensor regression-based model can predict intra-organ radiosensitivity in a data-driven manner, providing a compelling parameter distribution associated with the development of LUTS after I-125 seed implantation for prostate cancer. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: KOBAYASHI, K., MURAKAMI, N., TAKAHASHI, K., INABA, K., IGAKI, H., HAMAMOTO, R., ITAMI, J. Tags: Clinical Studies Source Type: research

Palliative Radiotherapy of Primary Glioblastoma
Conclusion: Patients with a KPS ≤50 have a poor survival prognosis and appear good candidates for short-course radiotherapy. Selected patients with better KPS may be considered for more aggressive treatments. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: WITTELER, J., SCHILD, S. E., RADES, D. Tags: Clinical Studies Source Type: research

Prognosis of Immune-related Adverse Events in Patients With Advanced Gastric Cancer Treated With Nivolumab or Pembrolizumab: A Multicenter Retrospective Analysis
Conclusion: The occurrence of irAEs was associated with a better clinical outcome of ICIs in patients with AGC. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: ANDO, T., UEDA, A., OGAWA, K., MOTOO, I., KAJIURA, S., NAKAJIMA, T., HIRANO, K., OKUMURA, T., TSUKADA, K., HARA, T., SUZUKI, N., NAKADA, N., HORIKAWA, N., FUJII, T., YASUDA, I. Tags: Clinical Studies Source Type: research

Coexistence of Emphysema With Non-small-cell Lung Cancer Predicts the Therapeutic Efficacy of Immune Checkpoint Inhibitors
Conclusion: Recognizing emphysema coexisting with NSCLC may help predict the therapeutic efficacy of ICIs in such patients. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: TAKAYAMA, Y., NAKAMURA, T., FUKUSHIRO, Y., MISHIMA, S., MASUDA, K., SHODA, H. Tags: Clinical Studies Source Type: research

Radiation to the Primary Tumor in Metastatic Anaplastic Thyroid Cancer
Conclusion: Radiation to the primary tumor in metastatic anaplastic thyroid cancer is safe and offers durable local control. Treatment intensification including concurrent or sequential chemotherapy and radiation dose escalation were associated with longer survival rates and should be considered in selected patients with metastatic disease. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: AUGUSTIN, T., OLIINYK, D., RAUCH, J., KOEHLER, V. F., SPITZWEG, C., BELKA, C., KÄSMANN, L. Tags: Clinical Studies Source Type: research

Micropapillary Bladder Cancer Metastatic to the Breast: A Case Report and Brief Literature Review
Conclusion: Breast metastases from BC are unusual and consequently difficult to identify without non-invasive tools. Clinical history and histological study play a pivotal role in determining the correct diagnosis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: LIEVORE, E., RUNZA, L., GHIDINI, M., GALASSI, B., GALLIOLI, A., BEBI, C., BOERI, L., BLUNDO, C., ROSSI, C. F., LONGO, F., ALBO, G., MONTANARI, E., DE LORENZIS, E. Tags: Clinical Studies Source Type: research

Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer
Conclusion: Favorable dose distributions with CIRT were demonstrated compared with 3DCRT and VMAT for esophageal cancer. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: TAKAKUSAGI, Y., YOSHIDA, D., KUSANO, Y., KANO, K., ANNO, W., TSUCHIDA, K., MIZOGUCHI, N., SERIZAWA, I., KATOH, H., IMURA, K., TAKAYAMA, Y., MINOHARA, S., KAMADA, T. Tags: Clinical Studies Source Type: research

CD133 Expression Predicts Relapse in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemotherapy
Conclusion: CD133 expression may be a predictive biomarker for postoperative relapse in patients with LARC who received NAC before surgery. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: OI, H., OKUYAMA, T., MIYAZAKI, S., ONO, Y., OYA, M. Tags: Clinical Studies Source Type: research

Evaluation of Sodium (23Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimers Disease
Conclusion: 23Na-MRI has the potential to be developed as a useful biomarker for the diagnosis of AD. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: MOHAMED, S. A., HERRMANN, K., ADLUNG, A., PASCHKE, N., HAUSNER, L., FRÖLICH, L., SCHAD, L., GRODEN, C., KERL, H. U. Tags: Clinical Studies Source Type: research

A Comparative Study of Pigmented and Non-pigmented Basal Cell Carcinoma in Reflectance Confocal Microscopy
Background/Aim: Basal cell carcinoma (BCC) is a common skin cancer, especially in the elderly population. The probability of BCC development increases past the age of 55. Dermoscopy and reflectance confocal microscopy (RCM) are two modern tools useful in the diagnosis of BCC. Patients and Methods: This is a retrospective study conducted on a group of 21 patients with a confirmed diagnosis of BCC. All patients were examined by dermoscopy and RCM. Dermoscopic images were taken using a videodermoscope. RCM was performed in three layers: epidermal, dermoepidermal junction (DEJ), and superficial dermal layer. In each layer, a f...
Source: In Vivo - January 5, 2021 Category: Research Authors: POGORZELSKA-ANTKOWIAK, A., GRZEGORCZYN, S., CORNELI, P., SZEPIETOWSKI, J. C. Tags: Clinical Studies Source Type: research

Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer - 19 Years of Experience
Conclusion: The type of surgery had no impact on OS. Markers and hormonal status of liver metastases are important factors affecting prognosis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: PROCHAZKOVA, K., PIVOVARCIKOVA, K., ROUSAROVA, M., VODICKA, J., HOSEK, P., TRESKOVA, I., HES, O., KUCERA, R., TOPOLCAN, O., TRESKA, V. Tags: Clinical Studies Source Type: research

Comparison of Conventional Fractionation and Accelerated Fractionation With Concomitant Boost for Radiotherapy of Non-metastatic Stage IV Head-and-Neck Cancer
Conclusion: Accelerated fractionation with concomitant boost appeared superior to conventional fractionation and can be considered for patients with stage IV SCCHN not suitable for radiochemotherapy. Larger studies are needed to confirm these findings. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NARVAEZ, C., SCHILD, S. E., RADES, D. Tags: Clinical Studies Source Type: research

Sarcopenia may Influence the Prognosis in Advanced Thyroid Cancer Patients Treated With Molecular Targeted Therapy
Conclusion: Sarcopenia could be a prognostic factor in patients with advanced thyroid cancer receiving molecular targeted therapy. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NISHIYAMA, A., STAUB, Y., SUGA, Y., FUJITA, M., TANIMOTO, A., OHTSUBO, K., YANO, S. Tags: Clinical Studies Source Type: research

The Epidemiology, Staging and Outcomes of Sarcomatoid Hepatocellular Carcinoma: A SEER Population Analysis
Background: Hepatocellular carcinoma (HCC) subtypes differ in terms of histopathology and prognosis. Sarcomatoid HCC is rare and literature concerning the survival of patients with sarcomatoid HCC is scarce. Materials and Methods: Data of patients with sarcomatoid HCC, diagnosed from 1989 to 2016, were extracted from the Surveillance, Epidemiology and End Results (SEER) database. We evaluated the baseline and tumor related data, overall survival (OS), disease-specific survival and the performance (Harrell’s concordance index – OS c-index) of the eighth edition of the American Joint Committee on Cancer TNM stagi...
Source: In Vivo - January 5, 2021 Category: Research Authors: GIANNIS, D., MORSY, S., GEROPOULOS, G., ESAGIAN, S. M., SIOUTAS, G. S., MORIS, D. Tags: Clinical Studies Source Type: research

Adolescents and Young Adults (AYAs) With Initially Localized and Metastatic Bone Sarcomas: A Retrospective Single Center Analysis of Side Effect Management
Conclusion: The two studied protocols were well-tolerated in the AYA patients included in this study. Dose reductions instead of dose delays should be considered when side effects occur. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: MINICHSDORFER, C., STEINBRECHER, O., KÖLZ, M., SCHMID, M., RADERER, M., BRODOWICZ, T., LAMM, W. Tags: Clinical Studies Source Type: research

Prognostic Factors in Hormone-sensitive Prostate Cancer Patients Treated With Combined Androgen Blockade: A Consecutive 15-year Study at a Single Japanese Institute
Conclusion: CAB should be considered as a treatment option for strictly selected patients with mHSPC, even though novel treatments are available. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: MIYAZAWA, Y., SEKINE, Y., ARAI, S., OKA, D., NAKAYAMA, H., SYUTO, T., NOMURA, M., KOIKE, H., MATSUI, H., SHIBATA, Y., SUZUKI, K. Tags: Clinical Studies Source Type: research

Predictors for Grip Strength Loss in Patients With Chronic Liver Diseases
Background/Aim: To elucidate factors associated with secular changes of grip strength (GS) in patients with chronic liver diseases (CLDs) (n=241, 102 males, median age=63 years, 87 liver cirrhosis cases). Materials and Methods: GS (kg/year) was defined as [GS value (second time) – GS value (first time)]/[time interval between the first and second time]. GS loss (GSL) was defined as GS
Source: In Vivo - January 5, 2021 Category: Research Authors: NISHIKAWA, H., YOH, K., ENOMOTO, H., IKEDA, N., TAKASHIMA, T., AIZAWA, N., NISHIMURA, T., NISHIGUCHI, S., IIJIMA, H. Tags: Clinical Studies Source Type: research

Sphenoid Bone Pneumatisation on Lateral Cephalograms of Patients With Neurofibromatosis Type 1
Background/Aim: Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease that causes tumors and many developmental disorders, e.g., cranial dysplasia. The purpose of this retrospective study was to analyse the pneumatisation of the sphenoid bone in NF1. Patients and Methods: The anonymised lateral cephalograms of 166 NF1 patients and 166 age- and sex-matched controls were examined for anterior-posterior sphenoid pneumatisation. The patient group analysis considered whether the patients had been affected by a facial plexiform neurofibroma (FPNF). Results: Sphenoid pneumatisation was significantly lower in ...
Source: In Vivo - January 5, 2021 Category: Research Authors: FRIEDRICH, R. E., SCHEUER, H. T., KERSTEN, J. F., SCHEUER, H. A. Tags: Clinical Studies Source Type: research

Metabolic-targeted Combination Therapy With Dichloroacetate and Metformin Suppresses Glioblastoma Cell Line Growth In Vitro and In Vivo
Conclusion: Compounds targeting tumor cell metabolism could become potential treatment options for glioblastoma multiforme. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: KORSAKOVA, L., KRASKO, J. A., STANKEVICIUS, E. Tags: Experimental Studies Source Type: research

Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis
Background/Aim: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated. Therefore, we investigated the immunohistochemical expression of syndecan-1 in chronic liver diseases (CLDs) and its probable role in hepatic fibrosis. Materials and Methods: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections of biopsy material obtained from 128 patients diagnosed with CLDs. The correlation between syndecan-1 expression and the stage of fibrosis was investigate...
Source: In Vivo - January 5, 2021 Category: Research Authors: CHARCHANTI, A., KANAVAROS, P., KONIARIS, E., KATAKI, A., GLANTZOUNIS, G., AGNANTIS, N. J., GOUSSIA, A. C. Tags: Experimental Studies Source Type: research

Culture Separation, Identification and Unique Anti-pathogenic Fungi Capacity of Endophytic Fungi from Gucheng Salvia Miltiorrhiza
Conclusion: The anti-fungal activities of the endophytic fungus from Salvia miltiorrhiza were confirmed for the first time, and this may benefit crop quality and production in the future. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: WANG, G.-K., YANG, J.-S., HUANG, Y.-F., LIU, J.-S., TSAI, C.-W., BAU, D.-T., CHANG, W.-S. Tags: Experimental Studies Source Type: research

MicroRNA Deregulation in Papillary Thyroid Cancer and its Relationship With BRAF V600E Mutation
Conclusion: Over-expression of selected miRNAs in PTC compared to normal thyroid gland tissue and nodular goitre was found. Moreover, miR-221 may serve as a prognostic marker as its over-expression was significantly associated with recurrent tumors. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: CELAKOVSKY, P., KOVARIKOVA, H., CHROBOK, V., MEJZLIK, J., LACO, J., VOSMIKOVA, H., CHMELAROVA, M., RYSKA, A. Tags: Experimental Studies Source Type: research

Enamel Matrix Derivative in Diffusion Chamber Implanted Subcutaneously in Rat Induces Formation of Fibrous Connective Tissue Containing Abundant Blood Vessels
Conclusion: The results indicated that EMD can induce the formation of both connective tissue and blood vessels. This bioactivity may contribute to the mechanism whereby EMD induces tissue regeneration. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: YOKOSE, S., KATO, Y., MATSUMOTO, K., KLOKKEVOLD, P. R., TAKEI, H. H., KAWAZU, H., SAKAGAMI, H. Tags: Experimental Studies Source Type: research

IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular Leucomalacia Model
Conclusion: PVL increased the number of early neuronal cells in the SVZ, reducing the survival of mature neurons in the cerebral cortex; IGF-1 reversed these effects. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: KIM, D.-J., CHO, S.-Y., KIM, S.-U., JO, D.-W., HWANG, H.-I., SHIN, H.-K., JUN, Y.-H. Tags: Experimental Studies Source Type: research

High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma
Conclusion: A high MCM6 expression level may be a promising biomarker to predict tumor progression, metastasis, and survival in patients with ccRCC. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: JANG, N.-R., BAEK, J., KO, Y., SONG, P. H., GU, M.-J. Tags: Experimental Studies Source Type: research

Relationship Between Insulin-Receptor Substrate 1 and Langerhans Islet in a Rat Model of Type 2 Diabetes Mellitus
Conclusion: The reduction of IRS1 was weakly correlated with the destruction of Langerhans’ islets, suggesting there is an intermediate step between both parameters. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: ATMODJO, W. L., LARASATI, Y. O., JO, J., NUFIKA, R., NAOMI, S., WINOTO, I. Tags: Experimental Studies Source Type: research

Effects of Different Media on Human T Regulatory Cells Phenotype
Conclusion: Appropriate protocols of cell isolation and storage are important for providing appropriate conditions for cell growth. This is crucial when analyzing small cell populations like Tregs. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: GŁACZYNSKA, M., MACHCINSKA, M., DONSKOW-LYSONIEWSKA, K. Tags: Experimental Studies Source Type: research