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< em > Chromolaena odorata < /em > (L.) R. M. King and H. Robinson Leaves Aqueous Extract Improves the Femoral Head in Ethanol-Induced Osteonecrosis in Rats
Evid Based Complement Alternat Med. 2023 Jun 28;2023:5436771. doi: 10.1155/2023/5436771. eCollection 2023.ABSTRACTChronic alcohol consumption damages bone formation and causes bone pathology, including osteonecrosis of the femoral head. The aim of this work was to evaluate the effects of the leaf aqueous extract of Chromolaena odorata (C. odorata) on the femoral head in ethanol-induced osteonecrosis in rats. Animals received alcohol (40°) at 3 g/kg for 12 weeks. A group of animals were sacrificed to attest to the instalment of osteonecrosis by using histopathological analysis. The remaining animals received alcohol concom...
Source: Evidence-based Complementary and Alternative Medicine - July 7, 2023 Category: Complementary Medicine Authors: Florence Tsofack Ngueguim Raceline Kamkumo Gounoue Jean Hubert Donfack Sandra Manefen Simo Josiane Jouonzo Rodrigue Ngapout Fifen Paul Desire Djomeni Dzeufiet Th éophile Dimo Source Type: research

In vitro anti-inflammatory activity and ameliorative effects on gastric ulcers of Licania rigida benth seed extract
AbstractLicania rigida Benth., a Brazilian endemic plant, has been traditionally used for treating inflammation and stomach pain. This work investigates the anti-inflammatory and gastroprotective activities of the ethanolic extract fromL. rigida seeds (EELr) by in vitro and in vivo methods. The phytochemical profile was determined and the in vitro antioxidant activity was investigated by radical scavenging and thiobarbituric acid reactive substances methods. The ovalbumin denaturation method was used with sodium diclofenac as standard for the in vitro anti-inflammatory activity assessment. Acetylsalicylic acid was used to ...
Source: Inflammopharmacology - July 7, 2023 Category: Drugs & Pharmacology Source Type: research

Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways
Biomed Pharmacother. 2023 Jun 29;165:115068. doi: 10.1016/j.biopha.2023.115068. Online ahead of print.ABSTRACTPrevious report indicated that nicorandil potentiated morphine antinociception and attenuated hepatic injury in liver fibrotic rats. Herein, the underlying mechanisms of nicorandil/morphine interaction were investigated using pharmacological, biochemical, histopathological, and molecular docking studies. Male Wistar rats were injected intraperitoneally (i.p.) with carbon tetrachloride (CCl4, 40%, 2 ml/kg) twice weekly for 5 weeks to induce hepatic fibrosis. Nicorandil (15 mg/kg/day) was administered per os (p.o.) f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Asser F Bedair Ahmed Wahid Nesrine S El-Mezayen Amira F El-Yazbi Hadeel A Khalil Nayera W Hassan Elham A Afify Source Type: research

The genus Scorzonera L. (Asteraceae): A comprehensive review on traditional uses, phytochemistry, pharmacology, toxicology, chemotaxonomy, and other applications
CONCLUSION: This review provides information on traditional usage, phytochemistry, pharmacology, toxicology, chemotaxonomy, other applications aspects, and future prospects of the genus Scorzonera. However, only around one third of Scorzonera species have been studied so far. This review may be used as the basis for future endeavors, including further biological and chemical investigations, and efforts of seeking more applications.PMID:37390877 | DOI:10.1016/j.jep.2023.116787
Source: Herpes - June 30, 2023 Category: Infectious Diseases Authors: Yuan Gong Zhuan-Ning Shi Jun Yu Xiao-Feng He Xian-Hua Meng Quan-Xiang Wu Ying Zhu Source Type: research

Ashwagandha root extract ’s phenolic compound counteracts alloxan’s effects on oxidative stress, inflammatory cytokines, and peripheral neuropathy in rats
AbstractDespite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures. Finding potential alternative therapies is necessary because conventional therapies have associated side effects and poor efficacy. In this regard, a study was conducted that offered substitute therapeutic agents in place of the alloxan injection. The target study pathway after alloxan injection is oxidative stress and inflammatory pathways, according to the study point. It argues that multitarget therapies must be developed to combat inflammation brought on by diabetic...
Source: Comparative Clinical Pathology - June 30, 2023 Category: Pathology Source Type: research

Citrus fruits could help 'alleviate' painful arthritis symptoms in weeks, expert shares
The antioxidant and anti-inflammatory properties hidden in colourful citruses could help ease pain and stiffness linked to arthritis, according to an expert.
Source: Daily Express - Health - June 29, 2023 Category: Consumer Health News Source Type: news

Fibromyalgia: one year in review 2023
This article discusses various aspects of FM described in scientific papers published in 2022 and indexed in the PubMed database, including the most recent diagnostic acquisitions (especially in relation to the juvenile form of FM), risk factors, co-morbidities and objective measures. Emphasis is placed on the importance of identifying FM early and improving diagnostic methods (e.g. physical measurements, including walking test performance, hand grip force, and autonomic tests). The article also considers hypotheses concerning the pathophysiology of FM, including the role of inflammation, gut dysbiosis, and neuroinflammati...
Source: Clinical and Experimental Rheumatology - June 28, 2023 Category: Rheumatology Authors: Valeria Giorgi Laura Bazzichi Alberto Batticciotto Greta Pellegrino Manuela Di Franco Silvia Sirotti Fabiola Atzeni Alessandra Alciati Fausto Salaffi Piercarlo Sarzi Puttini Source Type: research

Strawberry drink could reduce arthritis knee pain and inflammation in weeks
The antioxidant and anti-inflammatory properties hidden in strawberries could help ease painful arthritis symptoms, according to research.
Source: Daily Express - Health - June 18, 2023 Category: Consumer Health News Source Type: news

Molecules, Vol. 28, Pages 4791: Phytochemical Profiling, Antioxidant and Tyrosinase Regulatory Activities of Extracts from Herb, Leaf and In Vitro Culture of Achillea millefolium (Yarrow)
mierz Głowniak Achillea millefolium L. is one of the most known medicinal plants with a broad spectrum of applications in the treatment of inflammation, pain, microbial infections and gastrointestinal disorders. In recent years, the extracts from A. millefolium have also been applied in cosmetics with cleansing, moisturizing, shooting, conditioning and skin-lightening properties. The growing demand for naturally derived active substances, worsening environmental pollution and excessive use of natural resources are causing increased interest in the development of alternative methods for the production of plant-based in...
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Karolina Czech Katarzyna Gawe ł-Bęben Agnieszka Szopa Wirginia Kukula-Koch Thomas Jakschitz G ünther Bonn Shah Hussain Pawe ł Kubica Halina Ekiert Kazimierz G łowniak Tags: Article Source Type: research

Therapeutic activity of lipoxin A4 in TiO2-induced arthritis in mice: NF- κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms
ConclusionLXA4 might target recruited leukocytes and primary afferent nociceptive neurons to exert analgesic and anti-inflammatory activities in a model resembling what is observed in patients with prosthesis inflammation.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research