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Nutrition: Antidoxidants

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Total 1669 results found since Jan 2013.

Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis
In this study, a kartogenin (KGN)@PLGA-GelMA/PRP composite hydrogel was designed and used as a carrier of ADSCs-based therapies in disc repair. Injectable composite hydrogel act as a carrier for controlled release of KGN and deliver ADSCs to the degenerative disc. The released KGN can stimulate the differentiation of ADSCs into a nucleus pulposus (NP) -like phenotype and boost antioxidant capacity of ADSCs via activating Nrf2/TXNIP/NLRP3 axis. Furthermore, the composite hydrogel combined with ADSCs attenuated the in vivo degeneration of rat IVDs, maintained IVD tissue integrity and accelerated the synthesis of NP-like extr...
Source: Free Radical Biology and Medicine - May 6, 2023 Category: Biology Authors: Feng Wang Kai Guo Liping Nan Shuguang Wang Jiawei Lu Qiang Wang Zhaoyu Ba Yufeng Huang Desheng Wu Source Type: research

Daidzein attenuated paclitaxel-induced neuropathic pain via the down-regulation of TRPV1/P2Y and up-regulation of Nrf2/HO-1 signaling
AbstractPaclitaxel (PTX) is an anti-microtubule agent, used for the treatment of various types of cancers; however, it produces painful neuropathy which limits its use. Many neuroprotective agents have been introduced to mitigate PTX-induced neuropathic pain (PINP), but they pose many adverse effects. The purpose of this study was to evaluate the pharmacological characteristics of soy isoflavone, and daidzein (DZ) in attenuating PINP. At the beginning of the investigation, the effect of DZ was confirmed through behavioral analysis, as it reduced pain hypersensitivity. Moreover, changes in the histological parameters were r...
Source: Inflammopharmacology - May 5, 2023 Category: Drugs & Pharmacology Source Type: research

Fractionated whole body γ-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative potential of ebselen
This study aimed to investigate the antioxidant and anti-inflammatory effects of EB in an arthritic irradiated model. This goal was achieved by subjecting adjuvant-induced arthritis (AIA) rats to fractionated whole body γ-irradiation (2 Gy/fraction once per week for 3 consecutive weeks, for a total dose of 6 Gy) and treating them with EB (20 mg/kg/day, p.o) or methotrexate (MTX; 0.05 mg/kg; twice/week, i.p) as a reference anti-RA drug. The arthritic clinical signs, oxidative stress and antioxidant biomarkers, inflammatory response, expression of NOD-like receptor protein-3 (NLRP-3) inflammasome, receptor activator of ...
Source: Inflammopharmacology - May 2, 2023 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 28, Pages 3771: The Effects of Essential Oils on the Nervous System: A Scoping Review
In conclusion, essential oils showed promising effects on the nervous system, which can be further applied to their use in functional foods, drinks, and alternative therapy.
Source: Molecules - April 27, 2023 Category: Chemistry Authors: Apsorn Sattayakhom Sineewanlaya Wichit Phanit Koomhin Tags: Review Source Type: research

Chrysin, a 5,7-dihydroxyflavone restrains inflammatory arthritis in rats via subsiding oxidative stress biomarkers and inflammatory cytokines
This study was intended to appraise the anti-inflammatory and anti-arthritic potential of Chrysin (CR), a natural dietary flavone found in several plant genera, includingPassiflora andPropalis, and honey. The in vitro anti-arthritic potential was assessed by protein denaturation and membrane stabilization assays. The acute anti-inflammatory action was assessed by Carrageenan and Xylene induced oedema models in Wistar rats. For determining anti-arthritic potential, 0.1  ml Complete Freund’s adjuvant was injected into the left hind paw of rats to induce adjuvant-induced arthritis, followed by initiation of treatment with ...
Source: Inflammopharmacology - April 21, 2023 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 28, Pages 3371: Chemometrics of the Composition and Antioxidant Capacity of Hyptis crenata Essential Oils from Brazil
B. Figueiredo Hyptis crenata (Pohl) ex Benth is used in traditional medicine as an analgesic to treat general pain. Six Hyptis crenata samples (Hc-1 to Hc-6) were collected in Pará state, Brazil. The leaf essential oils were obtained by hydrodistillation, and GC-MS and GC-FID were used to analyze their chemical compositions. The antioxidant capacity was measured in vitro using DPPH and carotene/linoleic acid assays. Chemometrics analysis (PCA, HCA, and clustered heat map) were used to identify the sample relationships between those collected in this study and those from the literature (Hc-7 to Hc-16) sam...
Source: Molecules - April 11, 2023 Category: Chemistry Authors: Maria Nancy N. de Lima Jamile Silva da Costa Bruna A. Guimar ães Jofre Jacob S. Freitas William N. Setzer Joyce Kelly R. da Silva Jos é Guilherme S. Maia Pablo Luis B. Figueiredo Tags: Article Source Type: research

The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review
This study is a systematic review and meta-analysis of the effects of ALCAR on peripheral nerve injuries. This review examines studies on treating traumatic peripheral neuropathies in which ALCAR is administered to rats with sciatic nerve injury with an appropriate control group. The articles were divided based on the mode of ALCAR administration. If one method was used in more than one article, their results were entered in the "Revman5.4" software and were meta-analyzed. Studies were selected from 1994 to 2018 on rats with varying physical injuries to their sciatic nerves. In one study, ALCAR was provided to rats in thei...
Source: Neurochemical Research - April 10, 2023 Category: Neuroscience Authors: Sara Pourshahidi Ahmad Reza Shamshiri Samira Derakhshan Saba Mohammadi Mahdi Ghorbani Source Type: research

Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial)
BMJ Open. 2023 Apr 6;13(4):e068363. doi: 10.1136/bmjopen-2022-068363.ABSTRACTINTRODUCTION: Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme binding and mitochondrial-protective mechanisms. RMC-035 is a modified, more soluble, variant of A1M and has been proposed as a novel targeted therapeutic protein to prevent CS-associated AKI (CS-AKI). RMC-035 was considered safe and generally well tolerated when evaluated in four clinical phase 1 studies.METHODS...
Source: Pain Physician - April 6, 2023 Category: Anesthesiology Authors: C David Mazer Niloufar Siadati-Fini Johannes Boehm Felix Wirth Andrej Myjavec Craig D Brown Jay L Koyner Andreas Boening Daniel T Engelman Tobias E Larsson Ronny Renfurm Benoit de Varennes Nicolas Noiseux Matthias Thielmann Andre Lamy Maxime Laflamme Thil Source Type: research

Mustard gas exposure instigates retinal M üller cell gliosis
In conclusion, NM-induced Müller cell gliosis via increased oxidative stress results in caspase-1-dependent activation of the NLRP3 inflammasome and cell death driven primarily by pyroptosis.PMID:37023936 | DOI:10.1016/j.exer.2023.109461
Source: Cell Research - April 6, 2023 Category: Cytology Authors: Binapani Mahaling Nishant R Sinha Sibabalo Sokupa Utkarsh Reddy Addi Rajiv R Mohan Shyam S Chaurasia Source Type: research

Metal-on-metal metaphyseal and ceramic-on-ceramic femoral neck arthroplasty: the impact on clinical results, oxidative stress and concentration of metal ions in serum and blood
ConclusionsMetal-on-metal articulation of the hip significantly increases the concentration of Cr and Co in blood, induces oxidative stress and modifies function of the antioxidant system and generates greater pain in the operated hip.
Source: European Journal of Orthopaedic Surgery and Traumatology - April 5, 2023 Category: Orthopaedics Source Type: research

A comprehensive review of structures, structure-activity relationships, extractions, and bioactivities of flavonoids from Citrus medica
CONCLUSIONS: This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.PMID:37005516 | DOI:10.2174/1386207326666230330083136
Source: Combinatorial Chemistry and High Throughput Screening - April 3, 2023 Category: Chemistry Authors: Jie Chen Neng-Xin He Qin-Yuan Wang Guang Wu Wenxia Wu Qiang Xin Zhi-Pei Sang Cai-Qing Zhu Yong-Zhong Wu Rong-Rui Wei Qin-Ge Ma Guangyu Cheng Source Type: research