Query: pain

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Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay
In this study, DT loaded CS nanoparticles (CS-NPs) were produced by spray drying method for oral drug delivery. Structures of CS-NPs were elucidated by particle size, zeta potential, SEM, DSC, FT-IR and 1H NMR. High encapsulation efficiency was obtained (73–84%) for the prepared formulations. In vitro release was examined in pH 1.2 buffer and pH 6.8 buffer. DT-loaded CS-NPs showed prolonged release, particularly at pH 6.8. Weibull kinetic model was found to fit best to DT release from CS-NPs in both release medium. The anti-inflammatory activity of optimum formulation (M-DT) was examined using the in vivo HET-CAM a...
Source: Microvascular Research - November 20, 2019 Category: Biochemistry Source Type: research

National Institutes of Health-Funded Anesthesiology Research and Anesthesiology Physician-Scientists: Trends, Promises, and Concerns.
This article studies current NIH funding trends and offers potential solutions to continue the historical trend of academic innovation and research that has characterized academic Anesthesiology. Using publicly available data, specifically the NIH REPORTeR and Blue Ridge Institute for Medical Research, we examined NIH trends in funding in academic Anesthesiology departments that have Anesthesiology residency training programs. When adjusted for inflation, median NIH funding of departments of Anesthesiology declined approximately 15% between 2008 and 2017. The majority (55%) of NIH funding to academic Anesthesiology departm...
Source: Pain Physician - November 20, 2019 Category: Anesthesiology Authors: Chandrakantan A, Adler AC, Stayer S, Roth S Tags: Anesth Analg Source Type: research

Oral repeated-dose toxicity studies of BIA 10–2474 in Wistar rat
Publication date: Available online 20 November 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): A. Wallace Hayes, Jerold F. Hardisty, Stephen B. Harris, Yoshimasa Okazaki, Klaus WeberAbstractBIA 10–2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor developed for the treatment of medical conditions which would benefit from enhanced levels of endogenous anandamide (AEA) such as pain disorders. During a Phase I clinical trial one subject died after receiving BIA 10–2474 and four other subjects displayed neurological signs. As part of series of papers presenting all the toxicology data available prior ...
Source: Regulatory Toxicology and Pharmacology - November 20, 2019 Category: Toxicology Source Type: research

The Case | Severe symptomatic hypocalcemia in a  patient with sickle cell disease
A 46-year-old woman with a history of sickle cell disease and associated predialysis stage V chronic kidney disease (CKD) with secondary hyperparathyroidism presented with fever, severe extremity pain, and perioral numbness. On examination, she had a prominent Chvostek ’s sign, carpopedal spasm, hyperactive tendon reflexes, and a nontender mass in the left lobe of her thyroid gland. She was not on bisphosphonates or calcimimetics and had not been taking her prescribed calcitriol for 2 weeks.
Source: Kidney International - November 20, 2019 Category: Urology & Nephrology Authors: Phillip Gregoire, Vikas Srinivasan Sridhar, Robert G. Josse, Heather N. Reich Tags: Make Your Diagnosis Source Type: research

Can pain pumps reduce oral opioid consumptions?
Error - Cookies Turned Off "Our study showed 81.5% of patients with chronic noncancer pain reduced their average daily opioid dose immediately prior to or in the 395 days following implantation of an intrathecal drug‐delivery system. Overall, 43% of patients discontinued systemic opioids following implantation of an intrathecal drug‐delivery system, with discontinuation associated with significantly lower costs from a payer... Can pain pumps reduce oral opioid consumptions?
Source: Student Doctor Network - November 20, 2019 Category: Universities & Medical Training Authors: drusso Tags: Pain Medicine Source Type: forums

The changing landscape of abortion care: Embodied experiences of structural stigma in the Republic of Ireland and Northern Ireland
This study examines the embodied experience of 68 women who sought abortion services in Northern Ireland and the Republic of Ireland. Social stigma and restrictive abortion laws were major barriers to care at the time of study, providing the opportunity to explore the ways biological, social, and structural factors shape embodiment. Those who obtained an abortion either traveled abroad for clinical care or self-managed a medication abortion at home. Participant's perceptions of pain, the fetus, the method (medication vs. surgical), and environment in which they sought abortion care (at home vs. in a clinic) were shaped by ...
Source: Social Science and Medicine - November 20, 2019 Category: Psychiatry & Psychology Source Type: research

Nonsuicidal self-injury among adolescents in south-east Serbia
ConclusionThe results may have practical implications when it comes to taking preventive and therapeutic measures in the vulnerable adolescent population.
Source: International Journal of Pediatrics and Adolescent Medicine - November 20, 2019 Category: Pediatrics Source Type: research

Ubrogepant Eases Acute Migraine Pain, New Data Confirm Ubrogepant Eases Acute Migraine Pain, New Data Confirm
Final results from the ACHIEVE II randomized, placebo-controlled trial confirm the safety and efficacy of the CGRP antagonist for acute migraine. FDA action is expected next month.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - November 20, 2019 Category: Primary Care Tags: Neurology & Neurosurgery News Source Type: news

Utilization of Fluorescence Microangiography in Pediatric Acute Compartment Syndrome: A Case Report
We present the case of a 5-year-old female who developed compartment syndrome of her left foot 26 hours after sustaining an isolated crush injury to the distal forefoot. Her treatment included emergent fasciotomy in combination with 20 hyperbaric oxygen therapy treatments. The progression of her acute digital ischemia was monitored by using serial fluorescence microangiography studies performed at 17 hours, 7 days, and 3 weeks postinjury. Throughout these serial studies, improvement in hypofluorescence was noted involving the dorsolateral midfoot, as well as digits 3, 4, and 5, which correlated with physical examination. T...
Source: The Journal of Foot and Ankle Surgery - November 20, 2019 Category: Orthopaedics Source Type: research

Surgical treatment of acute aortic dissection Stanford type A in the third trimester of pregnancy: A case report
ConclusionAortic dissection in pregnancy is relatively rare, but physicians should be on high alert for the condition when a pregnant woman has chest pain. Early diagnosis and adequate treatment in addition to regular multidisciplinary care are crucial to achieve favourable results.
Source: Case Reports in Womens Health - November 20, 2019 Category: OBGYN Source Type: research

Interventional treatments for chronic pelvic pain caused by myometrial cysts
Publication date: Available online 19 November 2019Source: Case Reports in Women's HealthAuthor(s): Omar Viswanath, Ivan Urits
Source: Case Reports in Womens Health - November 20, 2019 Category: OBGYN Source Type: research

Prevalence of Depression and Its Influence on the Quality of Life of Jordanians Living in Residential Care Facilities
Conclusions Depression is common among NH residents in Jordan and is associated significantly with poor QoL. This study yielded empirical data that may be used to develop strategies to enhance or promote the mental health status and QoL of NH residents in Jordan.
Source: Journal of Nursing Research - November 20, 2019 Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research

Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/ chronic fatigue syndrome
Publication date: Available online 20 November 2019Source: Brain, Behavior, and ImmunityAuthor(s): Akiko Eguchi, Sanae Fukuda, Hirohiko Kuratsune, Junzo Nojima, Yasuhito Nakatomi, Yasuyoshi Watanabe, Ariel E. FeldsteinAbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, debilitating disorder with a wide spectrum of symptoms, including pain, depression, and neurocognitive deterioration. Over 17 million people around the world have ME/CFS, predominantly women with peak onset at 30-50 years. Given the wide spectrum of symptoms and unclear etiology, specific biomarkers for diagnosis and stratificat...
Source: Brain, Behavior, and Immunity - November 20, 2019 Category: Neurology Source Type: research

Women should sit like men to prevent hip and knee pain, surgeon says
Barbara Bergin MD sees thousands of patients a year with chronic knee and hip pain - and 90 percent of them are women. She believes it's because women sit cross-legged, tightening their ligaments.
Source: the Mail online | Health - November 20, 2019 Category: Consumer Health News Source Type: news

Animal-assisted Therapy for Children and Adolescents With Chronic Pain
Condition:   Chronic Pain Intervention:   Behavioral: Animal-assisted therapy Sponsor:   University Hospital, Basel, Switzerland Not yet recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)
Condition:   Pain Management Interventions:   Drug: Local anaesthetic;   Drug: Pudendal Nerve Block plus anesthesia Sponsor:   University of California, Los Angeles Recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Music During Paediatric Outpatient Wound Dressing Changes: Impact on Anxiety, Pain and Patient Satisfaction
Condition:   Wound Heal Intervention:   Other: Music intervention Sponsor:   KK Women's and Children's Hospital Completed
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Dry Needling With And Without Kinesio Taping ® in The Non-Specific Chronic Low Back Pain
Condition:   Non-Spesific Chronic Low Back Pain Intervention:   Device: Dry needling Sponsor:   Kars State Hospital Not yet recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling
Conditions:   Shoulder Pain;   Chronic Pain;   Musculoskeletal Injury Interventions:   Device: Dry Needling;   Other: Sham Dry Needling Sponsors:   Army-Baylor University Doctoral Program in Physical Therapy;   Brooke Army Medical Center Active, not recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Effects of PECS 1 Block on Venous Cancer Port Catheter
Condition:   Catheter; Pain (Indwelling Catheter) Intervention:   Procedure: Port-a-cath replacement Sponsor:   Bulent Ecevit University Active, not recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Can a Relaxometer Improve Discognition in Fibromyalgia Patients
Conditions:   Fibromyalgia Syndrome;   Fibromyalgia;   Pain, Chronic;   Impairment Intervention:   Other: Relaxometer Sponsor:   Azienda Ospedaliera Universitaria Integrata Verona Not yet recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Subacromial Injections for Shoulder Subacromial Pain Syndrome - Anterolateral vs Posterior Approach
Condition:   Shoulder Subacromial Pain Syndrome Interventions:   Procedure: Anterolateral subacromial steroid injection;   Procedure: Posterior subacromial steroid injection Sponsor:   Blackpool Teaching Hospitals NHS Foundation Trust Not yet recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain
Conditions:   Postoperative Pain;   Lidocaine Interventions:   Drug: Lidocaine 5% patch;   Drug: Placebo patch Sponsor:   Beijing Tiantan Hospital Not yet recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Prevention and Intervention of Neck Pain in Swiss Office-Workers
Conditions:   Neck Pain;   Headache;   Musculoskeletal Diseases;   Adherence, Patient;   Absenteeism;   Workplace;   Health Promotion;   Ergonomics;   Efficiency;   Presenteeism;   Occupational Health;   Surveys and Questionnaires;   Adult;   Exercise Therapy;   Work Performance Interventions:   Other: Multi-component intervention;   Other: Control Sponsors:   Zurich University of Applied Sciences;   Swiss National Science Foundation Recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

Comparison of Two Modes of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Neuropathic Radiculalgia
Conditions:   Neuropathic Pain;   Radiculopathy Intervention:   Device: CEFAR Primo Pro (TENS device) Sponsor:   Lille Catholic University Recruiting
Source: ClinicalTrials.gov - November 20, 2019 Category: Research Source Type: clinical trials

A case of mediastinal emphysema caused by root canal treatment using Er: YAG laser
We report a case of cervicofacial, subcutaneous, and mediastinal emphysema caused by dental laser treatment. The patient consulted our hospital complaining of swelling and pain across his both sides of the forehead, around the eye lid, from left cheek to the neck. On computed tomography, low absorption images indicative of air infiltration were found scattered from the forehead and left side of the face to the left side of the neck. We admitted the patient to monitor his airway, for bed rest, and to initiate prophylactic intravenous antibiotic therapy. Consequently, 6 days after the dental laser treatment, the patient’s ...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - November 20, 2019 Category: ENT & OMF Source Type: research

Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit
ConclusionFor the first time, this study provides pharmacological evidence for the analgesic and anti-inflammatory activities of EAF and the underlying mechanism, suggesting that EAF might be a potential candidate for reducing pain and inflammatory disorders.Graphical abstract
Source: Journal of Ethnopharmacology - November 20, 2019 Category: Drugs & Pharmacology Source Type: research

Pain as a determinant of health-related quality of life in patients with carpal tunnel syndrome; a case-controlled study.
Conclusions Patients with CTS have a significantly worse QoL compared to subjects without CTS. In addition, presence of pain is a significant determinant of physical functioning in patients who have been diagnosed with CTS. PMID: 31736403 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - November 20, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Roundtable: Perspectives on the current state of pain management in the United States
Publication date: November–December 2019Source: EXPLORE, Volume 15, Issue 6Author(s): Benjamin Kligler, Heather Tick, Arya Nielsen, Koshin Paley Ellison, Elizabeth (Betsy) Seng, Dionetta Hudzinski
Source: EXPLORE: The Journal of Science and Healing - November 20, 2019 Category: Complementary Medicine Source Type: research

Chuna manual therapy combined with acupuncture and cupping for frozen shoulder (adhesive capsulitis): Multicenter, randomized, patient-assessor blind, clinical trial
ConclusionFurther evidences about the effectiveness of the Chuna combined acupuncture and cupping therapy, and more verification data on the economic assessment are required.
Source: European Journal of Integrative Medicine - November 20, 2019 Category: Complementary Medicine Source Type: research

Herpes zoster vaccine reduces chances of shingles after stem cell transplants
This NIHR Signal says that the risk of shingles is about 10% per year in adults after autologous stem cell transplant. The evidence summary indicates that two doses of deactivated herpes zoster vaccine could be a safe and effective way to reduce that risk by about two thirds.This effect is similar to another, heat-treated, non-live vaccine. Either vaccine could reduce the pain and need for medical treatment associated with shingles, and long-lasting complications such as post-herpetic neuralgia. It ' s not yet known if people need to continue taking acyclovir as well.
Source: Current Awareness Service for Health (CASH) - November 20, 2019 Category: Consumer Health News Source Type: news

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Hao Luo, Hui-Zhu Liu, Wen-Wen Zhang, Megumi Matsuda, Ning Lv, Gang Chen, Zhen-Zhong Xu, Yu-Qiu ZhangSummaryThe proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation. However, the synaptic mechanisms by which IL-17 regulates pain transmission are unknown. Here, we report that glia-produced IL-17 suppresses inhibitory synaptic transmission in the spinal cord pain circuit and drives chemotherapy-induced neuropathic pain. We find that IL-17 not only enhances excitatory postsynaptic currents (EPSCs) but also suppresse...
Source: Cell Reports - November 20, 2019 Category: Cytology Source Type: research

Evaluation of the effects of metformin administration on morphine tolerance in mice
Publication date: Available online 19 November 2019Source: Neuroscience LettersAuthor(s): Samira Shirooie, Jamileh Esmaeili, Antoni Sureda, Nafiseh Esmaeili, Partow Mirzaee Saffari, Hasan Yousefi-Manesh, Ahmad Reza DehpourAbstractOpioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP levels, microglial activation and neuroinflammation, elevation of spinal mTOR ac...
Source: Neuroscience Letters - November 20, 2019 Category: Neuroscience Source Type: research

Two poems on pain.
Authors: Parisien D PMID: 31740539 [PubMed - in process]
Source: Canadian Medical Association Journal - November 20, 2019 Category: General Medicine Tags: CMAJ Source Type: research

Number Of Clinical Trial Study Sites Impacts Observed Treatment Effect Size: An Analysis Of Randomized Controlled Trials Of Opioids For Chronic Pain
Source: Journal of Pain Research - November 20, 2019 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury
About half of patients with spinal cord injury (SCI) develop debilitating central neuropathic pain (CNP), with no effective treatments. Thus, effective, safe, and novel therapies are needed urgently. Previously, docosahexaenoic acid (DHA) was reported to confer neuroprotection in preclinical SCI models. However, its therapeutic potential on SCI-CNP remains to be elucidated. Here, we demonstrated for the first time that intravenous DHA administrations with 3-day intervals (250 nmol/kg; starting 30 minutes after injury and maintained for 6 weeks) effectively prevented SCI-CNP development in a clinically relevant rat contusio...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Motor simulation is disturbed when experiencing pain
While the contribution of social processes to pain perception is well documented, surprisingly little is known about the influence of pain on social perception. In particular, an important question is how pain modulates the processing of other people's actions. To address this question, the current study tests, using automatic imitation, the hypothesis that pain interferes with motor simulation—that is, the processing of observed actions in the motor system. Participants in both experiments performed an automatic imitation task requiring them to abduct their index or little finger while they saw someone else performing e...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography
Chronic pain is a common and severely disabling disease whose treatment is often unsatisfactory. Insights into the brain mechanisms of chronic pain promise to advance the understanding of the underlying pathophysiology and might help to develop disease markers and novel treatments. Here, we systematically exploited the potential of electroencephalography to determine abnormalities of brain function during the resting state in chronic pain. To this end, we performed state-of-the-art analyses of oscillatory brain activity, brain connectivity, and brain networks in 101 patients of either sex suffering from chronic pain. The r...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Essential key messages about diagnosis, imaging, and self-care for people with low back pain: a modified Delphi study of consumer and expert opinions
People with back pain regularly search for information online; however, the quality of this online information is often poor. We established a list of the most important messages about diagnosis, imaging, and self-care for people with low back pain, based on consensus opinion and prioritised in order of importance. A list of key messages was derived from clinical practice guidelines for back pain. During 2 survey rounds, a Delphi panel of consumers with back pain and experts rated the importance of each item and suggested additional statements. Messages were retained that were rated as important by more than 70% of the pan...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Whole-brain functional network disruption in chronic pain with disk herniation
Brain functional network properties are globally disrupted in multiple musculoskeletal chronic pain conditions. Back pain with lumbar disk herniation (LDH) is highly prevalent and a major route for progression to chronic back pain. However, brain functional network properties remain unknown in such patients. Here, we examined resting-state functional magnetic resonance imaging-based functional connectivity networks in chronic back pain patients with clear evidence for LDH (LDH-chronic pain n = 146), in comparison to healthy controls (HCs, n = 165). The study was conducted in China, thus providing the opportunity to also ex...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Daily and bidirectional linkages between pain catastrophizing and spouse responses
Pain catastrophizing has been shown to predict greater pain and less physical function in daily life for chronic pain sufferers, but its effects on close social partners have received much less attention. The overall purpose of this study was to examine the extent to which pain catastrophizing is an interpersonal coping strategy that is maladaptive for patients and their spouses. A total of 144 older knee osteoarthritis patients and their spouses completed baseline interviews and a 22-day diary assessment. Multilevel lagged models indicated that, on days when patients reported greater catastrophizing in the morning, their ...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial
In 2014, the Paracetamol for Acute Low Back Pain (PACE) trial demonstrated that paracetamol had no effect compared with placebo in acute low back pain (LBP). However, noncompliance was a potential limitation of this trial. The aim of this study was to investigate the efficacy of paracetamol in acute LBP among compliers. Using individual participant data from the PACE trial (ACTN12609000966291), complier average causal effect (CACE), intention-to-treat, and per protocol estimates were calculated for pain intensity (primary), disability, global rating of symptom change, and function (all secondary) after 2 weeks of follow-up...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors
Complex regional pain syndrome (CRPS) is a posttraumatic pain condition with an incompletely understood pathophysiological basis. Here, we have examined the cellular basis of pain in CRPS using behavioral and electrophysiological methods in mice treated with IgG from CRPS patients, in combination with a paw incision. Mice were subjected to a hind paw skin–muscle incision alone, or in combination with administration of IgG purified from either healthy control subjects or patients with persistent CRPS. Nociceptive function was examined behaviorally in vivo, and electrophysiologically in vitro using skin–nerve preparation...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Recurrent low back pain patients demonstrate facilitated pronociceptive mechanisms when in pain, and impaired antinociceptive mechanisms with and without pain
This study investigated pronociceptive and antinociceptive mechanisms in recurrent LBP (RLBP) patients across painful and pain-free periods, compared with age/sex-matched asymptomatic controls. During a painful episode (day 0) and when pain-free (day 28), 30 RLBP patients were assessed and compared with 30 controls over the same timeframe. Pressure pain thresholds were recorded bilaterally on the arm, back, and leg. Cuff algometry was used to assess cuff pressure pain detection threshold and cuff pain tolerance threshold on the lower legs, as well as temporal summation of pain (10 repeated painful cuff test stimuli on the ...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Effects of open-label placebo on pain, functional disability, and spine mobility in patients with chronic back pain: a randomized controlled trial
Chronic back pain (CBP) is a major global health problem, while its treatment is hampered by a lack of efficacy and restricted safety profile of common frontline therapies. The present trial aims to determine whether a 3-week open-label placebo treatment reduces pain intensity and subjective and objective functional disability in patients with CBP. This randomized controlled trial, following a pretest–posttest design, enrolled 127 patients with CBP (pain duration>12 weeks) from the Back Pain Center, Neurology, University Hospital Essen, Germany. Patients randomized to the open-label placebo group received a 3-week open-l...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Conditioned pain modulation as a biomarker of chronic pain: a systematic review of its concurrent validity
Conditioned pain modulation (CPM) is a promising psychophysical biomarker of central pain mechanisms because it significantly discriminates patients with chronic pain from healthy controls. Nevertheless, it is unclear in what extent CPM assessed experimentally is correlated with clinical manifestations of pain. To assess the concurrent validity of CPM, we performed a systematic review of the literature reporting correlations between CPM responses and pain intensity, disability, duration, and area in patients with different chronic pain conditions. We included 32 studies that altogether encompassed data from 1958 patients a...
Source: Pain - November 19, 2019 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Perioperative intravenous low ‐dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo‐controlled study
ConclusionsIn this patient population with a high prevalence of neuropathic lower back pain undergoing major lower back surgery, a perioperative intravenous low ‐dose ketamine infusion did not have an effect on the prevalence of neuropathic lower back pain at six or 12 months postoperatively.
Source: European Journal of Pain - November 19, 2019 Category: Anesthesiology Authors: Christoph Czarnetzki, Jules Desmeules, Enrico Tessitore, Antonio Faundez, Jocelyne Chabert, Youssef Daali, Roxane Fournier, Elise Dupuis ‐Lozeron, Christine Cedraschi, Martin Richard Tramèr Tags: ORIGINAL ARTICLE Source Type: research

Overexpression Of miR138 Ameliorates Spared Sciatic Nerve Injury-Induced Neuropathic Pain Through The Anti-Inflammatory Response In Mice
Source: Journal of Pain Research - November 18, 2019 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Procedural Pain in the Adult Neurological Intensive Care Unit: A  Retrospective Study Examining Arterial Line Insertion
This was a retrospective chart review of procedural pain assessments and interventions during arterial catheter insertion in an adult neurological intensive care unit where patients with impaired consciousness are common. Overall, pain assessment was well documented (100%) by Registered Nurses, but not specific to arterial line insertion. Nurse practitioners commonly placed arterial lines and used local analgesia in over 75% of the documented procedures.
Source: Pain Management Nursing - November 18, 2019 Category: Nursing Authors: Kaylee Bray, Chris Winkelman, Esther I. Bernhofer, Jane F. Marek Tags: Original Article Source Type: research

Effects of Fitness Level and Exercise Intensity on Pain and Mood Responses
ConclusionExercise ‐induced hypoalgesia depends on exercise intensity and appears to be influenced by individual fitness status, independent of mood responses.
Source: European Journal of Pain - November 18, 2019 Category: Anesthesiology Authors: A. Schmitt, D. Wallat, C. Stangier, J.A. Martin, U. Schlesinger ‐Irsch, H. Boecker Tags: ORIGINAL ARTICLE Source Type: research