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Nutrition: Antidoxidants
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Total 1669 results found since Jan 2013.
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291
AbstractIn the scope of a research program with the goal of developing treatments for inflammatory diseases, the pharmacological evaluation of LQFM291, designed by molecular hybridization from butylated hydroxytoluene and paracetamol, was described. The antioxidant profile of LQFM291 was evaluated by electrochemical measurement. Also, acute or repeated treatments with equimolar doses to paracetamol were used to evaluate the antinociceptive and/or anti-inflammatory activities of LQFM291 in animal models. The toxicologic potential of LQFM291 was also evaluated and compared to paracetamol through biochemical and histopatholog...
Source: Inflammopharmacology - September 4, 2023 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory-antioxidant modifications and synbiotics improved health-related conditions in patients with progressive forms of multiple sclerosis: A single-center, randomized clinical trial
CONCLUSION: The anti-inflammatory-antioxidant-rich diet and synbiotics co-supplementation demonstrated improvements in fatigue, pain, sexual function, and bowel/bladder status among patients with progressive MS.PMID:37651846 | DOI:10.1016/j.ctcp.2023.101794
Source: Complementary Therapies in Clinical Practice - August 31, 2023 Category: Complementary Medicine Authors: Amir Reza Moravejolahkami Ahmad Chitsaz Akbar Hassanzadeh Zamzam Paknahad Source Type: research
Omega-3 nanoemulgel in prevention of radiation-induced oral mucositis and its associated effect on microbiome: a randomized clinical trial
CONCLUSIONS: Topical Omega-3 nanoemulgel demonstrated a beneficial effect in prevention of radiation-induced oral mucositis with a possibility of regulating oral microbial dysbiosis.PMID:37648997 | DOI:10.1186/s12903-023-03276-5
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Basma M Morsy Shahira El Domiaty Mohamed A M Meheissen Lamia A Heikal Marwa A Meheissen Nourhan M Aly Source Type: research
Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis
CONCLUSIONS: The included studies support the potential role of antioxidant vitamins in the management of endometriosis. Supplementation with antioxidant vitamins effectively reduced the severity of dysmenorrhea, improved dyspareunia and pelvic pain, and enhanced quality of life in these patients. Therefore, antioxidant vitamin therapy could be considered as an alternative treatment method, either alone or in combination with other approaches, for endometriosis-related pain.TRIAL REGISTRATION: PROSPERO registration number: CRD42023415198.PMID:37644533 | DOI:10.1186/s12958-023-01126-1
Source: Reproductive Biology - August 29, 2023 Category: Reproduction Medicine Authors: Sai-Hua Zheng Xiu-Xia Chen Yi Chen Zhi-Cong Wu Xian-Qian Chen Xue-Lian Li Source Type: research
Bach1 inhibitor HPP-D mediates γ-globin gene activation in sickle erythroid progenitors
Blood Cells Mol Dis. 2023 Aug 17;104:102792. doi: 10.1016/j.bcmd.2023.102792. Online ahead of print.ABSTRACTSickle cell disease (SCD) is the most common β-hemoglobinopathy caused by various mutations in the adult β-globin gene resulting in sickle hemoglobin production, chronic hemolytic anemia, pain, and progressive organ damage. The best therapeutic strategies to manage the clinical symptoms of SCD is the induction of fetal hemoglobin (HbF) using chemical agents. At present, among the Food and Drug Administration-approved drugs to treat SCD, hydroxyurea is the only one proven to induce HbF protein synthesis, however, it...
Source: Blood Cells, Molecules and Diseases - August 26, 2023 Category: Hematology Authors: Chithra D Palani Xingguo Zhu Manickam Alagar Otis C Attucks Betty S Pace Source Type: research
Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition
This study aimed to assess the efficacy of ethanolic extract ofSolanum torvum L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI) –induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuro pathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-...
Source: Molecular Neurobiology - August 10, 2023 Category: Neurology Source Type: research
Fucoidan-functionalized gelatin methacryloyl microspheres ameliorate intervertebral disc degeneration by restoring redox and matrix homeostasis of nucleus pulposus
This study aimed to examine the potential of fucoidan in protecting the matrix metabolism of NP cells and its therapeutic efficacy in the prevention of IVDD. In an inflammatory environment induced by interleukin (IL)-1β, fucoidan treatments demonstrated a dose-dependent enhancement of ECM production in NP cells, while concurrently reducing the expression of matrix degradation enzymes. The protective effect of fucoidan was mediated through the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and subsequent induction of antioxidant enzymes, whereas silencing Nrf2 abrogated the protection of fucoidan on NP ce...
Source: International Journal of Biological Macromolecules - August 8, 2023 Category: Biochemistry Authors: Yangfeng Li Xin Tian Wei He Chenyang Jin Chunju Yang Zejun Pan Yong Xu Huilin Yang Hao Liu Tao Liu Fan He Source Type: research
