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Nutrition: Antidoxidants
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Total 1669 results found since Jan 2013.
Mucoprotective effect of ellagic acid in 5 fluorouracil-induced intestinal mucositis model
This study aimed to evaluate the mucoprotective effects of ellagic acid on 5-FU-induced IM in mice. Mice were administered normal saline intraperitoneally for six days, followed by intraperitoneal injection of 5-FU for four days at a dose of 50 mg per kilogram. Ellagic acid was orally administered to the mice in groups III and IV in two doses (5 mg and 10 mg), with a one-hour time separation from 5-FU for ten days. At the end of the experiment, small intestine tissue was collected to measure the levels of antioxidant enzymes superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and inflammatory cytokines (I...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Dareen Mahmood Al-Hoshary Munaf Hashim Zalzala Source Type: research
Quercus floribunda Lindl. Ex A. Camus; a tremendous remedy against inflammation and associated symptoms
Fitoterapia. 2023 Jul 28:105628. doi: 10.1016/j.fitote.2023.105628. Online ahead of print.ABSTRACTCrude extracts prepared from aerial parts and nut galls of Quercus floribunda Lindl. Ex. A. Camus were evaluated for phytochemical screening, in vitro antioxidant, and in vivo analgesic, anti-inflammatory and antipyretic activities. Various solvents including methanol (M), acetone (A), distilled water (DW), distilled water + methanol (DWM) were used for extraction. Highest total phenolic (66.9 ± 0.05 μg GAE/mgE) and flavonoid content (38.4 ± 0.72 μg QE/mgE) were measured in QFAA extract by colorimetric methods. Cumulative ...
Source: Fitoterapia - July 30, 2023 Category: Biochemistry Authors: Fazilat Mehboob Ahmad Aroosa Zafar Madiha Ahmed Nausheen Akhtar Muhammad Mohtasheem Ul Hasan Mostafa A Abdel-Maksoude Mohammed Aufy Source Type: research
Nrf2 activation improves experimental rheumatoid arthritis
Free Radic Biol Med. 2023 Jul 24:S0891-5849(23)00545-2. doi: 10.1016/j.freeradbiomed.2023.07.016. Online ahead of print.ABSTRACTRheumatoid arthritis is a systemic autoimmune disease with pain and functional disorder of joints. Multiple strategies toward treatment of the rheumatoid arthritis are operating, while there are concerns of serious adverse effects of the therapeutic drugs. Here, we show that activation of Nrf2 (Nuclear factor erythroid 2-related factor 2) efficiently improves arthritis of SKG mice, which develop T cell-mediated autoimmune arthritis by zymosan A injection. We found that genetic Nrf2 activation by k...
Source: Free Radical Biology and Medicine - July 26, 2023 Category: Biology Authors: Anqi Zhang Takafumi Suzuki Saki Adachi Eiki Yoshida Shimon Sakaguchi Masayuki Yamamoto Source Type: research
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors
This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-induced mood disorders (i.e., anxiety and depression) by regulating oxidative stress, neurotrophic factors (NFs), and neuroinflammation. Chronic constrictive injury (CCI) was used to induce NP in the animals. Animals in the treatment groups received LUT in three doses of 10, 25, and 50 mg/kg for 21 days. The severity of pain and mood disorders were examined. Finally, animals were sacrificed, and their brain tissue was used for molecular and histopathological studies. CCI led to cold allodynia and thermal hyperalgesia. Mood alteration...
Source: International Immunopharmacology - July 21, 2023 Category: Allergy & Immunology Authors: Tahmineh Mokhtari Min Lu Ayman El-Meghawry El-Kenawy Source Type: research
The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats
Physiol Res. 2023 Jul 14;72(3):383-392.ABSTRACTRegular physical exercise is beneficial to the body. Acute exercise causes oxidant stress in many tissues including the liver by creating an unbalanced status between oxidant and antioxidant levels. Analgesic drugs are commonly consumed to reduce the pain after exercise. Acetaminophen (APAP), commonly used as an over-the-counter analgesic, can cause hepatotoxicity. The aim of this study was to investigate the effect and underlying mechanisms of APAP at subtoxic dose, which is given after the acute and exhaustive exercise on the rat livers. Male Wistar rats weighing 200-250 g w...
Source: Physiological Research - July 14, 2023 Category: Physiology Authors: I Aksu M Kiray C Gencoglu A Tas O Acikgoz Source Type: research
Molecules, Vol. 28, Pages 5376: Targeting Nrf2 and NF- & kappa;B Signaling Pathways in Inflammatory Pain: The Role of Polyphenols from Thinned Apples
In conclusion, we demonstrate that TAP extract is able to modulate inflammatory, oxidative, and painful processes, and is also useful in the treatment of the symptoms associated with paw edema.
Source: Molecules - July 13, 2023 Category: Chemistry Authors: Livia Interdonato Giulio Ferrario Marika Cordaro Ramona D ’Amico Rosalba Siracusa Roberta Fusco Daniela Impellizzeri Salvatore Cuzzocrea Giancarlo Aldini Rosanna Di Paola Tags: Article Source Type: research
< em > Chromolaena odorata < /em > (L.) R. M. King and H. Robinson Leaves Aqueous Extract Improves the Femoral Head in Ethanol-Induced Osteonecrosis in Rats
Evid Based Complement Alternat Med. 2023 Jun 28;2023:5436771. doi: 10.1155/2023/5436771. eCollection 2023.ABSTRACTChronic alcohol consumption damages bone formation and causes bone pathology, including osteonecrosis of the femoral head. The aim of this work was to evaluate the effects of the leaf aqueous extract of Chromolaena odorata (C. odorata) on the femoral head in ethanol-induced osteonecrosis in rats. Animals received alcohol (40°) at 3 g/kg for 12 weeks. A group of animals were sacrificed to attest to the instalment of osteonecrosis by using histopathological analysis. The remaining animals received alcohol concom...
Source: Evidence-based Complementary and Alternative Medicine - July 7, 2023 Category: Complementary Medicine Authors: Florence Tsofack Ngueguim Raceline Kamkumo Gounoue Jean Hubert Donfack Sandra Manefen Simo Josiane Jouonzo Rodrigue Ngapout Fifen Paul Desire Djomeni Dzeufiet Th éophile Dimo Source Type: research
