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Total 1669 results found since Jan 2013.

Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial
ConclusionPerioperative TEAS improved postoperative sleep quality, reduced postoperative pain and alleviated postoperative adverse effects in patients undergoing laparoscopic gastrointestinal tumor surgery resection. This may be associated with activating Nrf2/ARE signal pathway and decreasing its inflammatory actions.Trial registrationChinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx), ChiCTR2100054971.
Source: Pain and Therapy - March 14, 2023 Category: Anesthesiology Source Type: research

Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor
CONCLUSION: Our findings suggest that the investigated compound SIH 3 has the potential to be developed as an anti-nociceptive agent.PMID:36913176 | DOI:10.1007/s43440-023-00468-2
Source: Pharmacological Reports - March 13, 2023 Category: Drugs & Pharmacology Authors: Shivani Jaiswal None Akhilesh Vinod Tiwari Senthil Raja Ayyannan Source Type: research

Curcuma as an anti-inflammatory component in treating osteoarthritis
AbstractOsteoarthritis (OA) is nowadays the most common musculoskeletal progressive condition. In recent decades, incidence and prevalence of OA have increased significantly. It is estimated that the prevalence of OA among adults older than 60 is 12%, affecting about 240 million people globally. The cause has not been fully elucidated, and therefore, there is no cure at the moment. It is a multifactorial degenerative disease with an inflammatory component mediated by numerous proinflammatory and anti-inflammatory cytokines, chemokines, and growth factors. OA is not yet fully understood; therefore, therapeutic interventions...
Source: Rheumatology International - March 12, 2023 Category: Rheumatology Source Type: research

Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in vitro and in silico Approaches
This study investigated the antioxidant properties, individual phenolic compounds, total phenolic and total flavonoid contents (HPLC-MS analysis), reducing power and metal chelating effects of four extracts obtained from A. elongatum (ethyl acetate (EA), methanol (MeOH), methanol/water (MeOH/water) and infusion). The inhibitory activity of the extracts were also determined against acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase enzymes. The MeOH/water extracts contained the highest amount of phenolic contents (28.85 mg GAE/g) while the highest total flavonoid content was obtained with MeOH ...
Source: Chemistry and Biodiversity - March 9, 2023 Category: Biochemistry Authors: Mohamad Fawzi Mahomoodally Gokhan Zengin Seebaluck-Sandoram Roumita Giovanni Caprioli Ahmed M Mustafa Diletta Piatti Evren Y ıldıztugay Gunes Ak Ay şe Esra Karadağ Asaad Khalid Ashraf N Abdalla Abdullahi Ibrahim Uba Fatih Demirci Source Type: research

Phytochemical analysis and antibacterial/antifungal activity of the essential oil of Phlomis olivieri Benth in Iran
AbstractPhlomis olivieri Benth. is an aromatic plant endemic to Iran belonging to the Lamiaceae family. It is used to treat pain, stomach ache and common cold in Iranian traditional medicine.P. olivieri also has valuable biological properties including antioxidant, antimicrobial and analgesic ones. This was the first study designed to assess the quality, quantity and antimicrobial activity ofPhlomis olivieri Benth. essential oil (POEO). Samples were randomly collected from flowering twigs of this species in three locations between Azeran and Kamoo in Kashan, Iran at peak flowering in June 2019. Water distillation extractio...
Source: Inflammopharmacology - March 8, 2023 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 28, Pages 2448: Antibacterial, Antibiofilm and Anti-Inflammatory Activities of Eugenol Clove Essential Oil against Resistant Helicobacter pylori
annem Eugenol essential oil (EEO) is the major component in aromatic extracts of Syzygium aromaticum (clove) and has several biological properties, such as antibacterial, antioxidant, and anti-inflammatory activities, as well as controlling vomiting, coughing, nausea, flatulence, diarrhea, dyspepsia, stomach distension, and gastrointestinal spasm pain. It also stimulates the nerves. Therefore, the aim of this study was to extract and purify EEO from clove buds and assess its ability to combat resistant Helicobacter pylori. Additionally, EEO’s anti-inflammatory activity and its ability to supp...
Source: Molecules - March 7, 2023 Category: Chemistry Authors: Mahmoud K. M. Elbestawy Gamal M. El-Sherbiny Saad A. Moghannem Tags: Article Source Type: research

What the Ozempic Obsession Misses About Food and Health
In a country obsessed with thinness, Ozempic is the latest in a long line of weight loss miracles. After its approval in 2017 to help manage blood sugar in Type 2 diabetics, news quickly spread that it also caused weight loss; fast-forward to 2023 and #Ozempic has over 300 million views on TikTok. Celebrities and influencers quickly jumped on the Ozempic bandwagon, and by now the drug has achieved mainstream appeal. So much so that Type 2 diabetics are struggling to access it due to its intense demand. According to Komodo Health, over 5 million prescriptions were written for Ozempic or the similar drug Mounjaro in 2022. [t...
Source: TIME: Health - February 21, 2023 Category: Consumer Health News Authors: Tess Bredesen Tags: Uncategorized freelance health Source Type: news

Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective
Pathol Res Pract. 2023 Feb 9;243:154368. doi: 10.1016/j.prp.2023.154368. Online ahead of print.ABSTRACTEndometriosis, the very serious disease in women creates a huge financial burden worldwide, which is comparable to diabetes mellitus. In addition to the typical pelvic pain, endometriosis is related to low life quality and decreased work efficiency; clinical consequences include mood complaints, metabolic impairments, inflammation, immunologic problems, and elevated malignancy risks. Several risk factors are correlated with endometriosis including elevated oxidative and nitrosative stress, long-lasting inflammation, raise...
Source: Pathology, Research and Practice - February 12, 2023 Category: Pathology Authors: Mehran Sharifi Nesa Rajabpoor Nikoo Bita Badehnoosh Rana Shafabakhsh Reza Asemi Russel J Reiter Zatollah Asemi Source Type: research

< em > Moringa oleifera < /em > : An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects
Int J Mol Sci. 2023 Jan 20;24(3):2098. doi: 10.3390/ijms24032098.ABSTRACTMoringa oleifera, also known as the "tree of life" or "miracle tree," is classified as an important herbal plant due to its immense medicinal and non-medicinal benefits. Traditionally, the plant is used to cure wounds, pain, ulcers, liver disease, heart disease, cancer, and inflammation. This review aims to compile an analysis of worldwide research, pharmacological activities, phytochemical, toxicological, and ethnomedicinal updates of Moringa oleifera and also provide insight into its commercial and phytopharmaceutical applications with a motive to h...
Source: Molecular Medicine - February 11, 2023 Category: Molecular Biology Authors: Ashutosh Pareek Malvika Pant Madan Mohan Gupta Pushpa Kashania Yashumati Ratan Vivek Jain Aaushi Pareek Anil A Chuturgoon Source Type: research

Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders
Cell Mol Neurobiol. 2023 Feb 8:1-22. doi: 10.1007/s10571-023-01324-w. Online ahead of print.ABSTRACTMelatonin is ubiquitous molecule with wide distribution in nature and is produced by many living organisms. In human beings, pineal gland is the major site for melatonin production and to lesser extent by retina, lymphocytes, bone marrow, gastrointestinal tract, and thymus. Melatonin as a neurohormone is released into circulation wherein it penetrates all tissues of the body. Melatonin synthesis and secretion is supressed by light and enhanced by dark. Melatonin mostly exerts its effect through different pathways with melato...
Source: Cellular and Molecular Neurobiology - February 8, 2023 Category: Cytology Authors: Sheikh Bilal Ahmad Aarif Ali Midhat Bilal Shahzada Mudasir Rashid Amir Bashir Wani Rahil Razak Bhat Muneeb U Rehman Source Type: research