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Total 126957 results found since Jan 2013.

Aggressive variant prostate cancer: A case report and literature review
CONCLUSION: We should reach consensus definitions of the AVPC and other androgen receptor-independent subtypes of PCA and develop new biomarkers to identify groups of high-risk variants. It is crucial to complete a puncture biopsy of the tumor or metastatic lesion as soon as possible in patients with advanced PCA who exhibit clinical features such as low Prostate-specific antigen levels, high carcinoembryonic antigen levels, and insensitivity to hormones to determine the pathological histological type and to create a more aggressive monitoring and treatment regimens.PMID:37731555 | PMC:PMC10507546 | DOI:10.12998/wjcc.v11.i26.6213
Source: Clinical Prostate Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Xiang-Tao Weng Wen-Li Lin Qi-Man Pan Tao-Fen Chen Si-Yi Li Chi-Ming Gu Source Type: research

Research Progress and New Perspectives of Anticancer Effects of Emodin
In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.PMID:37732372 | DOI:10.1142/S0192415X23500787
Source: The American Journal of Chinese Medicine - September 21, 2023 Category: Complementary Medicine Authors: Wu Liu Eskandar Qaed Yuelin Zhu Wenzhang Tian Yizhen Wang Le Kang Xiaodong Ma Zeyao Tang Source Type: research

Suppressive effect of Tripterygium hypoglaucum (Levl.) Hutch extract on rheumatoid arthritis in mice by modulating inflammasome and bile acid metabolism
In this study, we aimed to explore the critical role of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and bile acid (BA) in the anti-RA mechanism. Complete Freund's adjuvant (CFA)-injected mice were treated with THH extract (250 mg/kg/d) for 35 days, and joint swelling and disease scores were measured. After THH treatment, the joint swelling and RA disease score in CFA-treated mice significantly subsided. The increased ratios of lymphocytes, monocytes, and white blood cells were attenuated by THH treatment. Notably, THH treatment blocked the inflammation in both joints and colons by suppressing the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Junping Zheng Jianghui Hu Yong Yang Lei Xiong Huabing Yang Zhigang Zhang Nan Jiang Hongtao Liu Source Type: research

Association of fat mass and fat-free mass with all-cause and cause-specific mortality in Asian individuals: A prospective cohort study
CONCLUSIONS: The mortality risk increases in those with excessively high or low FMI and FFMI, yet the associations between FMI, FFMI, and the risk of death varied across subgroups and causes of death.PMID:37731225 | DOI:10.1002/oby.23878
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Zhijun Ying Chi Pang Wen Huakang Tu Wanlu Li Sai Pan Yizhan Li Yihong Luo Zecheng Zhu Min Yang Zhenya Song David Ta-Wei Chu Xifeng Wu Source Type: research

Effectiveness and safety of REBACIN as a non-invasive intervention for persistent high-risk human papillomavirus infection: A real-world prospective multicenter cohort study
CONCLUSION: This study confirmed that REBACIN can effectively and safely eliminate persistent hrHPV infection, which the clearance rate of HPV16/18 is higher than that of HPV52/58, the clearance rate of single-type infection is higher than that of multiple-type infections, and the clearance rate in young patients is higher than that in elder patients, providing a guidance for REBACIN application in clearing hrHPV persistent infection in real-world settings.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry Registration Number: ChiCTR1800015617 http://www.chictr.org.cn/showproj.aspx?proj=26529 Date of Registration...
Source: Gynecologic Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Fei Chen Guo-Nan Zhang Wei Lei Shu-Guang Zhou Ying Zhang Lin Liu Ying Jia Rong-Kai Xie Xiu-Fang Tian Jie Guo Yue-Bo Yang Xue-Feng Wang Xiao-Mei Wu Qi-Jian Sun Xu Zhou Yang Lin You-Zhong Zhang Jun-Qi Ma Yu-Xiu Liu Yi-Fan Cheng Jian-Cui Chen Quan-Xin Qu Don Source Type: research

< em > PLEKHA4 < /em > is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas
CONCLUSIONS: PLEKHA4 is highly expressed in glioma tissues and correlated with tumour stemness, immune cell infiltration and proliferation, suggesting its potential as a novel prognostic biomarker and therapeutic target in glioma.PMID:37735118 | DOI:10.31083/j.jin2205130
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Xin Gao Yukun Liu Shunming Hong Hui Yang Bing Guan Xiaodong Ma Source Type: research

Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: A bibliometric and visualized analysis
This study provides the first bibliometric analysis of papers in this research area using visualization software and data information mining. It provides insights into this field's current status, hot spots, and trends. However, many outstanding issues in this research area still need further exploration to provide a theoretical basis for its clinical application.
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research

Complete genome analysis of echovirus 30 strains isolated from hand-foot-and-mouth disease in Yunnan province, China
CONCLUSIONS: This study extends the whole genome sequence of E30 in GenBank, in which mutations and recombinations have driven the evolution of E30 and further improved and enriched the genetic characteristics of E30, providing fundamental data for the prevention and control of diseases caused by E30. Furthermore, we demonstrated the value of continuous and extensive surveillance of enterovirus serotypes other than the major HFMD-causing viruses.PMID:37730633 | DOI:10.1186/s12985-023-02179-9
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Ming Zhang Daqian He Yuhan Liu Yue Gong Wenxun Dong Ying Chen Shaohui Ma Source Type: research

Genomic signatures reveal selection in Chinese and European domesticated geese
In this study, we sequenced and analyzed the genome of the YL goose and the Hortobagy goose to combine with other previously sequenced goose populations for in-depth analysis. The population genetic variations in Stone geese, East Zhejiang White Geese, Taihu geese and Zi geese were also identified and compared. The results showed that admixture gene flow existed in the YL geese population, which was introgressed by Chinese geese, suggesting that gene flow events were frequent and widespread among domesticated geese. Further selected sweep analysis identified candidate genes and metabolic pathways that may be related to the...
Source: Animal Genetics - September 20, 2023 Category: Genetics & Stem Cells Authors: Lihua Zhang Haiying Li Bihui Tang Xiaoyu Zhao Yingping Wu Teng Jiang Yingying Yao Jiahui Li Yang Yao Lin Wang Source Type: research

How does financial decentralization synergies carbon reduction and pollution control in China?
This study looks at how carbon reduction, pollution management, and monetary decentralization in China all work together for a win-win situation. Since China is the most significant contributor to global warming, the country must implement policies to cut carbon emissions and curb pollution. One possible answer is financial decentralization, delegating federal financial responsibilities, and decisions to state and regional governments. The study used the weighted matrix analysis technique, LM matrix analysis technique, and ARDL short-run and long-run analysis estimates. However, the degree to which it will help China reduc...
Source: Environmental Science and Pollution Research International - September 20, 2023 Category: Environmental Health Authors: Dongmei Mu Daifu Yang Source Type: research

Can network infrastructure construction improve the low-carbon innovation of Chinese enterprises?
This study considers the implementation of the "Broadband China" strategy as an exogenous policy shock and examines the impact of network infrastructure construction (NIC) on the low-carbon innovation (LCI) of enterprises and its underlying mechanisms by using a progressive difference-in-difference model based on the data of Chinese listed enterprises from 2009 to 2020. This study finds that NIC can improve the LCI of enterprises. After the elimination of the sample selection bias and selection of the urban slope as the exogenous instrumental variable, the conclusions remained robust. The results of the mechanism test show...
Source: Environmental Science and Pollution Research International - September 20, 2023 Category: Environmental Health Authors: Haikuo Zhang Yuankun Li Source Type: research

Loot boxes, gambling-related risk factors, and mental health in Mainland China: A large-scale survey
Addict Behav. 2023 Sep 15;148:107860. doi: 10.1016/j.addbeh.2023.107860. Online ahead of print.ABSTRACTLoot boxes can be bought with real-world money to obtain random content inside video games. Loot boxes are viewed by many as gambling-like and are prevalently implemented globally. Previous Western and international studies have consistently found loot box spending to be positively correlated with problem gambling. Previous Western studies presented mixed results as to the correlations between loot box purchasing and gambling-related risk factors, mental wellbeing, and psychological distress. A large-scale survey of adult...
Source: Addictive Behaviors - September 20, 2023 Category: Addiction Authors: Leon Y Xiao Tullia C Fraser Rune Kristian Lundedal Nielsen Philip W S Newall Source Type: research

< em > Natronosalvus halobius < /em > gen. nov., sp. nov., < em > Natronosalvus caseinilyticus < /em > sp. nov., < em > Natronosalvus vescus < /em > sp. nov., < em > Natronosalvus rutilus < /em > sp. nov. and < em > Natronosalvus amylolyticus < /em > sp. nov., halophilic archaea isolated from salt lakes and soda lakes
Int J Syst Evol Microbiol. 2023 Sep;73(9). doi: 10.1099/ijsem.0.006036.ABSTRACTFive halophilic archaeal strains (AGai3-5T, KZCA101T, CGA3T, WLHS1T and WLHSJ1T) were isolated from salt lakes and soda lakes in PR China. These strains had low 16S rRNA gene similarities (91.3-96.0 %) to closely related species of the family Natrialbaceae and may represent a new genus of the family. Phylogenetic and phylogenomic analyses revealed that these strains formed a distinct clade, separate from the nearby genera Natronobiforma and Saliphagus. The average nucleotide identity, digital DNA-DNA hybridization and average amino acid identity...
Source: International Journal of Systematic and Evolutionary Microbiology - September 20, 2023 Category: Microbiology Authors: Shun Tan Mu Cheng Xin-Xin Li Yao Hu Xue Ma Jing Hou Heng-Lin Cui Source Type: research

< em > Chryseobacterium luquanense < /em > sp. nov., a casein-hydrolysing bacterium from the Jiaozi Mountain in Yunnan, PR China
Int J Syst Evol Microbiol. 2023 Sep;73(9). doi: 10.1099/ijsem.0.006031.ABSTRACTStrain KC 927T was isolated during an investigation of the soil bacteria diversity on Jiaozi Mountain, central Yunnan, Southwest China. The strain was Gram-stain-negative, rod-shaped, non-motile, oxidase-negative, catalase-positive and aerobic. Results of 16S rRNA gene alignment and phylogenetic analysis indicated that strain KC 927T was a member of the genus Chryseobacterium and closely related to Chryseobacterium caseinilyticum GCR10T (98.4%), Chryseobacterium piscicola DSM 21068T (98.3 %) and 'Chryseobacterium formosus' CCTCC AB 2015118T (97....
Source: International Journal of Systematic and Evolutionary Microbiology - September 20, 2023 Category: Microbiology Authors: Guo-Xing Zhu Xiu Chen Ya-Jie Wu Hai-Long Wang Yu Jiao Zi-Chao Liu Yue Zhang Shu-Kun Tang De-Jun Kong Yan-Ru Cao Source Type: research

Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study
CONCLUSIONS: This is the first registered case-control study designed to investigate a stacked ensemble model integrating several cfDNA features generated from a bisulfite-free whole methylome sequencing assay. These features include methylation patterns, fragmentation profiles, and chromosomal copy number changes, with the aim of identifying the GC population. This study will determine whether multidimensional analysis of cfDNA will prove to be an effective strategy for distinguishing patients with GC from nonmalignant individuals within the Chinese population. We anticipate the THEMIS model will complement the standard-o...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yongjun Han Jiangpeng Wei Weidong Wang Ruiqi Gao Ning Shen Xiaofeng Song Yang Ni Yulong Li Li-Di Xu Weizhi Chen Xiaohua Li Source Type: research