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Condition: Chronic Obstructive Pulmonary

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Total 1666 results found since Jan 2013.

Risk of new ‐onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study
ConclusionThe findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.
Source: International Forum of Allergy and Rhinology - February 22, 2023 Category: Allergy & Immunology Authors: Annemarie G. Hirsch, Brian S. Schwartz, Cara Nordberg, Bruce K. Tan, Robert P. Schleimer, Robert C. Kern, Anju T. Peters, Karen Bandeen ‐Roche, Ashton E. Lehmann Tags: ORIGINAL ARTICLE Source Type: research

Primary Care COPD Screening Tool Shows Mixed Results
(MedPage Today) -- The five-question CAPTURE screening tool showed high specificity but low sensitivity in detecting undiagnosed chronic obstructive pulmonary disease (COPD) in primary care. Of 110 patients with undiagnosed but clinically significant...
Source: MedPage Today Allergy - February 15, 2023 Category: Allergy & Immunology Source Type: news

Risk of new onset and prevalent disease in chronic rhinosinusitis: a prospective cohort study
Conclusion: The findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - February 9, 2023 Category: Allergy & Immunology Authors: Annemarie G. Hirsch, Brian S. Schwartz, Cara Nordberg, Bruce K. Tan, Robert P. Schleimer, Robert C. Kern, Anju T. Peters, Karen Bandeen ‐Roche, Ashton E. Lehmann Tags: ORIGINAL ARTICLE Source Type: research

Levels of immunoglobulin isotypes in serum and respiratory samples of patients with chronic obstructive pulmonary disease: protocol for a systematic review and meta-analysis
Introduction Chronic obstructive pulmonary disease (COPD) is an inflammatory respiratory disorder characterised by the progressive worsening of lung function. Acute exacerbation of COPD (AECOPD) is a leading contributor to patient morbidity, mortality and hospitalisations. The clinical significance of immunoglobulin (Ig) levels in COPD patients is not well established and is in need of further investigation. Methods and analysis We will conduct a systematic review to describe levels of different Ig isotypes (IgG, IgA and IgM) in various samples (serum, sputum and bronchoalveolar lavage) of patients with COPD. IgE levels i...
Source: BMJ Open - February 9, 2023 Category: General Medicine Authors: Unninayar, D., Shea, B., Cameron, D. W., Cowan, J. Tags: Open access, Immunology (including allergy) Source Type: research

Further evidence of a type 2 inflammatory signature in chronic obstructive pulmonary disease or emphysema
CONCLUSION: We conclude that, similar to asthma, lung neutrophils from patients with COPD display IL-5Ra(CD125) on their surface. This along with the frequent presence of IL-4 and IL-5 in airway fluid further suggests a possible role of the T2 pathway in contributing to COPD severity.PMID:36736724 | DOI:10.1016/j.anai.2023.01.024
Source: Annals of Allergy, Asthma and Immunology - February 3, 2023 Category: Allergy & Immunology Authors: Larry Borish W Gerald Teague James T Patrie Kristin W Wavell Andrew J Barros H Charles Malpass Monica G Lawrence Source Type: research

Hospital Frailty Risk Score Not Up to Snuff for Patients With COPD Exacerbation
(MedPage Today) -- Use of the population-based Hospital Frailty Risk Score (HFRS) may misclassify frailty in hospitalized patients with chronic obstructive pulmonary disease (COPD) exacerbation compared with use of the beside Clinical Frailty Scale...
Source: MedPage Today Allergy - February 2, 2023 Category: Allergy & Immunology Source Type: news

Further evidence of a type 2 inflammatory signature in chronic obstructive pulmonary disease or emphysema
There is increasing recognition of a type 2 (T2) inflammatory pattern in a subset of patients with COPD and/or emphysema, characterized by blood and airway eosinophilia. The mechanism underlying this is not well established. The recognition that CD125 (IL-5Ra) is expressed on some lung neutrophils as well as eosinophils in patients with asthma led us to speculate that CD125 may also be expressed on lung neutrophils in patients with COPD/emphysema.
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Larry Borish, W. Gerald Teague, James T. Patrie, Kristin W. Wavell, Andrew J. Barros, H. Charles Malpass, Monica G. Lawrence Source Type: research

Safety and tolerability of pur1800, an orally inhaled narrow spectrum kinase inhibitor, in patients with stable chronic obstructive pulmonary disease (copd).
This study evaluated the safety, tolerability and pharmacokinetics of inhaled doses of PUR1800 for 14 days in patients with stable and 1+ y ears of Grade II/III COPD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Margaret Wasilewski, Russell Clayton, Dave Singh, Jason Perry, Aidan Curran Source Type: research

Real-world inhaler usage patterns obtained from a digital health platform
Objective data measured by digital inhalers have the potential to inform patient management. This analysis assessed real-world inhaler usage data from a Digital Health Platform (DHP) used by patients with asthma or COPD in the US.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Henry Chrystyn, Nawar Bakerly, Mark Levy, Guilherme Safioti, Sanjay Gandhi, John Logan, Bogdan Muresan Source Type: research

Cadmium Toxicity Induces Pyroptosis In Macrophages
Cadmium (Cd) toxicity contributes to chronic obstructive pulmonary disease (COPD) and other smoking-related lung disease. Caspase-1, gasdermin D (GSDMD), and gasdermin E (GSDME) are key proteins responsible for the initiation of pyroptosis. We hypothesize Cd induces host immune and inflammatory cell death in a macrophage model (RAW 264.7).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Samuel Camilli, Carli Busler, Apoorva Desaraju, Ramani Soundararajan, Richard Lockey Source Type: research

Low immunoglobulin levels affect the course of COPD in hospitalized patients
Chronic obstructive pulmonary disease (COPD) affects up to 10% of Canadians. Patients with COPD may present with secondary humoral immunodeficiency as a result of chronic disease, poor nutrition or frequent co...
Source: Allergy, Asthma and Clinical Immunology - January 29, 2023 Category: Allergy & Immunology Authors: Nami Shrestha Palikhe, Malcena Niven, Desi Fuhr, Tristan Sinnatamby, Brian H. Rowe, Mohit Bhutani, Michael K. Stickland and Harissios Vliagoftis Tags: Research Source Type: research

Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD
Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are released upon airway epithelial injury from insults such as viruses and cigarette smoke, and play critical roles in the activation of immune cell populations such as mast cells, eosinophils and group 2 innate lymphoid cells. Both cytokines were previously understood to primarily drive type 2 (T2) inflammation, but there is emerging evidence for a role for these alarmins to additionally mediate non-T2 inflammation, with recent clinical trial data in asthma and COPD cohorts with non-T2 inflammation providing support. Currently available trea...
Source: European Respiratory Review - January 25, 2023 Category: Respiratory Medicine Authors: Calderon, A. A., Dimond, C., Choy, D. F., Pappu, R., Grimbaldeston, M. A., Mohan, D., Chung, K. F. Tags: COPD and smoking, Pulmonary pharmacology and therapeutics, Asthma and allergy Reviews Source Type: research

Living without eosinophils: evidence from mouse and man
The enduring view of eosinophils, as immune effector cells whose primary function is host defence against infection by helminths and other microbial pathogens, sets the stage for a fundamental question regarding the safety of therapeutic eosinophil depletion. If eosinophils are significantly reduced or altogether depleted in an effort to alleviate the negative effects of tissue eosinophilia and eosinophilic inflammation in conditions such as asthma, COPD, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome, would these patients become susceptible to infecti...
Source: European Respiratory Journal - January 12, 2023 Category: Respiratory Medicine Authors: Jackson, D. J., Pavord, I. D. Tags: Asthma and allergy Reviews Source Type: research

Using a Two-Sample Mendelian Randomization Study Based on Genome-Wide Association Studies to Assess and Demonstrate the Causal Effects of Allergic Rhinitis on Chronic Lower Respiratory Diseases and Lung Function
Conclusions: We demonstrated and measured the causal effects of AR on asthma (OR = 14.37) and FEV1/FVC ratio (OR = 0.82), while there was no evidence to support a causal effect of AR on COPD, bronchiectasis, and IPF. These results suggest that AR tends to have a causal effect on lower airway disease of similar inflammatory types and can provide high-quality causal evidence for clinical practice as well as the pathogenesis and prevention of AR and asthma.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 11, 2023 Category: Allergy & Immunology Source Type: research

News beyond our pages
Because of emerging evidence of early life origins of chronic obstructive pulmonary disease (COPD), there is increasing interest in investigating the prognostic value of early lung function deficits. Dharmage et al (Lancet Respir Med 2022 Oct 13; https://doi.org/10.1016/S2213-2600(22)00364-2) utilized lifetime spirometry trajectories to identify 4 distinct patterns of obstruction and restriction. Patients with a mixed pattern (with both low FEV1/FVC ratio and low FVC trajectories) had the highest risk of developing COPD, although an obstructive-only pattern (with low FEV1 trajectory) was also associated with increased risk of COPD.
Source: Journal of Allergy and Clinical Immunology - January 1, 2023 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Tags: News beyond our pages Source Type: research