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Condition: Chronic Obstructive Pulmonary

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Total 1666 results found since Jan 2013.

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Allergy and asthma medication use in home ‐dwelling U.S. older adults
ConclusionAllergy and asthma medication use is prevalent among older adults and driven mostly by history of asthma or COPD. Additional sociodemographic factors predict allergy (but not asthma) medication use. Further studies are needed to evaluate efficacy of these drugs in the elderly.
Source: International Forum of Allergy and Rhinology - August 31, 2016 Category: Allergy & Immunology Authors: Gaurav S. Ajmani, Kristen E. Wroblewski, Fuad M. Baroody, Robert M. Naclerio, Jayant M. Pinto Tags: ORIGINAL ARTICLE Source Type: research

Immunoregulatory and immunostimulatory responses of bacterial lysates in respiratory infections and asthma.
CONCLUSION: Although successful prevention against all common respiratory pathogens is not possible, bacterial lysates seem capable of targeting specific immunocompetent cells through pathogen recognition receptor activation. Current challenges include clarifying the duality of immunoregulatory and immunostimulatory responses in children at risk for allergy. Larger clinical trials are required to elicit efficacy in allergy prevention. PMID: 25752734 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 6, 2015 Category: Allergy & Immunology Authors: Kearney SC, Dziekiewicz M, Feleszko W Tags: Ann Allergy Asthma Immunol Source Type: research

Challenges in the management of severe allergic asthma in the elderly
Ayse Bilge Ozturk,1 Sinem Iliaz21Department of Allergy and Immunology, 2Department of Pulmonary Medicine, Koç University Hospital, Istanbul, TurkeyAbstract: Little is known about the features of asthma and allergy in the elderly. A significant number of elderly patients with asthma have uncontrolled and severe asthma. This review aims to provide an analysis of the literature on the assessment and phenotype of severe allergic asthma in the elderly. Gaps and pitfalls in diagnostic and therapeutic approaches, as well as management of severe allergic asthma in the elderly, are also discussed.Keywords: allergy, asthma, e...
Source: Journal of Asthma and Allergy - March 16, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

Perceptions of Severe Asthma and Asthma-COPD Overlap Syndrome Among Specialists: A Questionnaire Survey.
CONCLUSIONS: Specialists had diverse perceptions and clinical practices regarding severe asthma and ACOS patients. This heterogeneity must be considered in future studies and strategy development for severe asthma and ACOS. PMID: 29676069 [PubMed]
Source: Allergy, Asthma and Immunology Research - April 22, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China.
CONCLUSIONS: Despite enhanced education on asthma self-management in China during recent years, few patients were using daily controller medications before the onset of their exacerbation, indicating that more educational efforts and considerations are needed. The findings of this study may improve our understanding of hospital admission for asthma exacerbation in mainland China and provide evidence for decision-making. PMID: 32141261 [PubMed]
Source: Allergy, Asthma and Immunology Research - March 8, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.
CONCLUSIONS: AX is associated with adult asthma with preserved lung function. Performing spirometry together with IOS is more beneficial than performing spirometry alone for diagnosing asthma in adult patients with preserved lung function. PMID: 32638563 [PubMed]
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Strategies for choosing a biologic for your patient with allergy or asthma
CONCLUSION: The numerous biologic options have made the selection of the best biologic for each patient a potential conundrum for clinicians. Adequate point of care biomarkers to facilitate personalized medical therapy are generally lacking. Furthermore, although clinically effective and generally safe, none of the biologics discussed in this review have induced long-standing disease remission. Nevertheless, these agents have given us the opportunity to treat the most severe patients and to better understand the biology of respiratory and allergic diseases. As knowledgeable physicians, we should embrace and be educated on ...
Source: Annals of Allergy, Asthma and Immunology - October 13, 2021 Category: Allergy & Immunology Authors: Tara Saco Israel C Ugalde Juan Carlos Cardet Thomas B Casale Source Type: research

Engineering approaches to develop the next generation of antibodies to respiratory targets.
Abstract Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) represent a significant health burden worldwide and are a major unmet medical need. Asthma affects over 300 million people and leads to 250,000 deaths per year, with an increasing prevalence particularly in developing countries. Although a large proportion of asthmatics are maintained on beta agonists and corticosteroids, there still remains a group of patients where these medicines fail to modulate symptoms and who may therefore benefit from monoclonal antibody based drugs that are aimed at controlling the diseas...
Source: Inflammation and Allergy Drug Targets - April 1, 2013 Category: Allergy & Immunology Authors: Vousden KA, Clarke DL, Lowe DC Tags: Inflamm Allergy Drug Targets Source Type: research

Predicting drug efficacy using integrative models for chronic respiratory diseases.
Abstract Animal models are vital instruments of the drug discovery process. In addition to assessing the efficacy of candidate molecules, in vivo disease models also help validate the therapeutic potential of molecular targets. Over recent years, several molecules that have shown efficacy in preclinical models of respiratory diseases have failed to translate into new medicines for chronic respiratory conditions such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. As such, many scientists have argued that these systems are of limited value; however, we propose that a more carefu...
Source: Inflammation and Allergy Drug Targets - April 1, 2013 Category: Allergy & Immunology Authors: Stevenson CS, Sridhar S, Phillips JE Tags: Inflamm Allergy Drug Targets Source Type: research

Inhalation delivery of protein therapeutics.
Abstract Inhaled therapeutics are used routinely to treat a variety of pulmonary diseases including asthma, COPD and cystic fibrosis. In addition, biological therapies represent the fastest growing segment of approved pharmaceuticals. However, despite the increased availability of biological therapies, nearly all inhaled therapeutics are small molecule drugs with only a single inhaled protein therapeutic approved. There remains a significant unmet need for therapeutics in pulmonary diseases, and biological therapies with potential to alter disease progression represent a significant opportunity to treat these chal...
Source: Inflammation and Allergy Drug Targets - April 1, 2013 Category: Allergy & Immunology Authors: Kane C, O'Neil K, Conk M, Picha K Tags: Inflamm Allergy Drug Targets Source Type: research

Vitamin D Deficiency and Acute Lung Injury.
Abstract Acute Lung Injury (ALI) and the more severe form Acute Respiratory Distress Syndrome (ARDS) remain a significant cause of morbidity and mortality in the critically ill patient. It is characterised by a severe inflammatory process resulting in diffuse alveolar damage, influx of neutrophils, macrophages and a protein rich exudate in the alveolar spaces caused by endothelial and epithelial injury. Improvements in outcomes are in part due to restrictive fluid management and protective lung ventilation however successful therapeutic strategies remain elusive with promising therapies failing to translate positi...
Source: Inflammation and Allergy Drug Targets - June 13, 2013 Category: Allergy & Immunology Authors: Parekh D, Thickett DR, Turner AM Tags: Inflamm Allergy Drug Targets Source Type: research

Interleukin-6 and Lung Inflammation: Evidences of A Causing Role in Inducing Respiratory System Resistance Increments.
Abstract Interleukin-6 has been shown to be increased in various pathological conditions involving the lungs, both experimentally induced in animals, or spontaneously occurring in humans. Experimental data demonstrating a significant role of interleukin-6 in commonly occurring respiratory system inflammatory diseases are reviewed. These diseases, i.e. asthma and chronic obstructive pulmonary disease, are characterised by respiratory system mechanical derangement, most of all because increased elastance and airway resistance. Recent findings showing a causative role of interleukin-6 in determining an airway resista...
Source: Inflammation and Allergy Drug Targets - July 10, 2013 Category: Allergy & Immunology Authors: Rubini A Tags: Inflamm Allergy Drug Targets Source Type: research