Further evidence of a type 2 inflammatory signature in chronic obstructive pulmonary disease or emphysema

There is increasing recognition of a type 2 (T2) inflammatory pattern in a subset of patients with COPD and/or emphysema, characterized by blood and airway eosinophilia. The mechanism underlying this is not well established. The recognition that CD125 (IL-5Ra) is expressed on some lung neutrophils as well as eosinophils in patients with asthma led us to speculate that CD125 may also be expressed on lung neutrophils in patients with COPD/emphysema.

Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Larry Borish, W. Gerald Teague, James T. Patrie, Kristin W. Wavell, Andrew J. Barros, H. Charles Malpass, Monica G. Lawrence Source Type: research