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Condition: Chronic Obstructive Pulmonary
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Total 1666 results found since Jan 2013.
Classifying asthma control using salivary and fecal microbiome in children with moderate to severe asthma: results from the SysPharmPediA study
Conclusions: Controlled and uncontrolled asthmatics could be differentiated in children based on their microbiome using machine learning, suggesting a link between asthma control and the microbiome. This suggests that the microbiome may be a potential target for a precision medicine approach to improve asthma control in children.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Blankestijn, J., Lopez-Rincon, A., Neerincx, A. H., Vijverberg, S. J., Hashimoto, S., Gorenjak, M., Sardon-Prado, O., Corcuera, P., Korta-Murua, J., Pino-Yanes, M., Potocnik, U., Wolff, C., Brandstetter, S., Toncheva, A. A., Kheiroddin, P., Harner, S., Ka Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Mast cell gene expression in eosinophilic COPD patients
We examined associations between mast cell gene expression and T2 biomarkers. We measured mast cell numbers in bronchial biopsies by immunohistochemistry.Results: We observed increased expression of tryptase and carboxypeptidase mRNA, and a mast cell specific 11-gene signature in bronchial brushings and sputum cells of eosinophilhigh compared to eosinophillow COPD patients. The 11-gene signature was associated with airway eosinophil numbers, and IL-13 gene expression in bronchial brushings and sputum, and with IL-5 in sputum only (rho 0.4 – 0.8 p<0.05). There was no difference in the number of tissue mast cells be...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Higham, A., Dungwa, J., Pham, T., Mccrae, C., Singh, D. Tags: 05.03 - Allergy and immunology Source Type: research
Relationship between interleukin-13 and transferrin receptor-1 responses in the pathogenesis of asthma
Conclusion: We show a critical role for IL-13-mediated increases in TFR1 responses in the pathogenesis of asthma, highlighting the potential to target TFR1 in other diseases associated with altered iron metabolism such as COPD, idiopathic pulmonary fibrosis & cystic fibrosis.Grant Support: University of Newcastle, HMRI
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pillar, A., Brown, A., Mayall, J., Weaver, J., Essilfie, A., Hoefel, G., Ali, M. K., Kim, R., Donovan, C., Gomez, H., Vanka, K. S., Tay, H., Kermani, N., Guo, Y., Mumby, S., Adcock, I., Anderson, G., Frazer, D., Johnstone, D., Milward, E., Hansbro, P., Wa Tags: 05.03 - Allergy and immunology Source Type: research
Birch pollen-induced seasonal allergic rhinitis and bronchial asthma: implication for allergen-specific immunotherapy in adults.
Conclusion: In common practice, it is much easier to assess the circumstances of the birch pollen SAR than the influence of this allergen on asthma. The above findings may facilitate asthmologist to determine the share of birch pollen allergy on asthma and support the referral of patients to birch allergen AIT.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Nevrlka, J., Selingerova, I., Nevrlkova, Z., Ditetova, K., Zdrazilova-Dubska, L. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research
Oral microbiome associated with asthma and COPD in a multicenter study
Oral bacteria may affect respiratory disease, but few studies have explored this in general population samples from different geographical regions. We aimed to explore the association between oral microbial community composition with asthma and COPD in the ECRHS3.Metagenomic sequencing (2x150 bp paired-end sequencing on Illumina platform) was performed on subgingival samples from 330 ECRHS participants in Bergen (NO), Melbourne (AU) and Tartu (EE) (median age: 53 years [range: 40-65] and 50% men). Alpha and beta diversity group differences were tested by Wilcoxon and PERMANOVA tests, respectively, for study centre, age, se...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Drengenes, C., Abramson, M., Jogi, O., Lodge, C., Real, F. G., Bertelsen, R. Tags: 05.03 - Allergy and immunology Source Type: research
Population PK/PD modelling of the anti-IL-33 antibody tozorakimab to predict pulmonary target engagement in patients with COPD
Conclusions: Our PK/PD model reliably predicts systemic target engagement by tozorakimab and can predict pulmonary target engagement. The model will help determine optimal tozorakimab dosing in future clinical trials.Reference1. Scott IC et al. Eur Respir J 2019 54:PA4072.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Sadiq, M. W., Yu, H., Astrand, M., Scott, I. C., Williams, A., Hewitt, L., White, N., Killick, H., Gavala, M., Reid, F., Kell, C., Pandya, H., Jimenez, E. Tags: 05.03 - Allergy and immunology Source Type: research
Three clinical phenotypes of COPD with each a characteristic immunological profile
Conclusion: Cluster analysis differentiated COPD in three clinical phenotypes with each a characteristic immunological profile, which may have relevance for development of targeted therapy strategies.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: van Zelst, C., In'T Veen, J., De Bruijn, M., Van Nimwegen, M., Van Der Ploeg, E., Krabbendam, L., Van Uden, D., Stadhouders, R., Hendriks, R., Braunstahl, G. Tags: 05.03 - Allergy and immunology Source Type: research
Differences in Innate Lymphoid Cell profiles between COPD, asthma, smoking controls and non-smoking healthy controls
Conclusion: Analyses of our patient cohorts reveal significant differences in the ILC-profiles of COPD patients compared to asthma patients and (smoking) controls, indicating that ILC-subsets in peripheral blood can discriminate between COPD inflammation and smoking exposure.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: van Zelst, C., In'T Veen, J., De Boer, G., De Bruijn, M., Van Nimwegen, M., Van Der Ploeg, E., Krabbendam, L., Van Uden, D., Stadhouders, R., Tramper-Stranders, G., Braunstahl, G., Hendriks, R. Tags: 05.03 - Allergy and immunology Source Type: research
ADAM17 and CD62L in BAL fluid as a measure of leukocyte transmigration in COPD, asthma, and healthy individuals
Leukocyte transmigration in and out of the airways is poorly understood in respiratory diseases. The role of a disintegrin and metalloprotease (ADAM) family is a controversial topic as to whether it helps or hinders leukocyte transmigration in asthma and chronic obstructive pulmonary disease (COPD). CD62L plays a prominent role for leukocyte migration as is cleaved by ADAM17 before transmigration. Therefore, we aimed to assess the levels of CD62L and ADAM17 present in airway samples from healthy individuals, asthmatics, and COPD patients.Bronchoalveolar lavage fluid (BALF) was collected from healthy (n=42, 10 smokers), COP...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Larsson, C., Van Der Burg, N., Ankerst, J., Bjermer, L., Tufvesson, E. Tags: 05.03 - Allergy and immunology Source Type: research
Soluble epoxide hydrolase inhibition alleviates inflammation in cigarette smoke-induced experimental COPD irrespective of dietary fat content
Conclusion: Both amount and composition of dietary fats impact disease features in COPD. Inhibition of sEH reduced airway inflammation and may prove useful as a therapeutic strategy.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Rehman, S. F., Budden, K. F., Quaranta, A., Fuchs, D., Shukla, S. D., Brown, A., Alemao, C., Balachandra, L., Gomez, H., Kumar, V., Idrees, S., Horvat, J., Wood, L. G., Wheelock, C., Hansbro, P. M. Tags: 05.03 - Allergy and immunology Source Type: research
A pilot trial of belimumab for atherosclerosis associated autoimmunity in COPD patients
Conclusion: Treatment with belimumab in COPD is safe and reduces anti-GRP78 levels, an autoantibody linked with CVD in this population.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mkorombindo, T., Wade, R. C., Yuan, K., Robison, S. W., Christenson, A. E., Wells, J. M., Dransfield, M. T., Duncan, S. R. Tags: 05.03 - Allergy and immunology Source Type: research
Enhanced early T cell activation and protection from hyper-inflammation in smoke exposed Cox4i2-/- infected mice with influenza
Respiratory virus infections are a major cause of concern in chronic obstructive pulmonary disease (COPD). Mitochondrial reactive oxygen species (mtROS) play an important role in immune function and increased mtROS levels may have an effect in COPD. Cox4i2 regulates ROS production at complex III and has been shown implicated in the development of emphysema.We hypothesize that Cox4i2–/– mice are protected from smoke-induced hyper-inflammation but also exhibit impaired T cell activation and antiviral immunity.We analyzed T cell subsets, BAL Albumin leakage and virus load via qPCR. C57BL/6 (WT) and Cox4i2–/&...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Berger, T., Garcia Castro, C. F., Lakshmi, V., Völkel, S., Sommer, N., Skevaki, C. Tags: 05.03 - Allergy and immunology Source Type: research
How consistent are blood eosinophil counts in a general population?
Conclusion: In the GP and in a HSP the overall proportion of high EOSb is small. Also, the longitudinal consistency of EOSb values is high, which may strengthen the value of a single measurement of EOSb as a biomarker.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Hartl, S., Breyer, M. K., Burghuber, O., Schiffers, C., Puchhammer, P., Ofenheimer, A., Breyer-Kohansal, R. Tags: 05.02 - Monitoring airway disease Source Type: research
Asthma chronic obstructive pulmonary disease and lower respiratory disorders
The Global Initiative for Asthma Strategy 2021 is an international guideline for the evaluation and management of asthma, and its recently published executive summary highlights some key changes.1 One of the new major guideline recommendations is the preferred use of as-needed inhaled corticosteroid-formoterol for step 1 and step 2 asthma in adults and adolescence. This strategy is often called single maintenance and reliever therapy. The Global Initiative for Asthma guideline also recommends long-acting muscarinic antagonists for severe asthma, along with consideration of daily azithromycin.
Source: Annals of Allergy, Asthma and Immunology - November 30, 2022 Category: Allergy & Immunology Authors: James T. Li Tags: Editorial Source Type: research
Low-Dose Morphine Not Helpful for COPD Patients With Chronic Dyspnea
(MedPage Today) -- Among patients with chronic obstructive pulmonary disease (COPD) and severe chronic breathlessness, short-term daily treatment with low doses of extended-release morphine did not significantly reduce the intensity of worst breathlessness...
Source: MedPage Today Allergy - November 22, 2022 Category: Allergy & Immunology Source Type: news
