Relationship between interleukin-13 and transferrin receptor-1 responses in the pathogenesis of asthma

Conclusion: We show a critical role for IL-13-mediated increases in TFR1 responses in the pathogenesis of asthma, highlighting the potential to target TFR1 in other diseases associated with altered iron metabolism such as COPD, idiopathic pulmonary fibrosis & cystic fibrosis.Grant Support: University of Newcastle, HMRI

Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pillar, A., Brown, A., Mayall, J., Weaver, J., Essilfie, A., Hoefel, G., Ali, M. K., Kim, R., Donovan, C., Gomez, H., Vanka, K. S., Tay, H., Kermani, N., Guo, Y., Mumby, S., Adcock, I., Anderson, G., Frazer, D., Johnstone, D., Milward, E., Hansbro, P., Wa Tags: 05.03 - Allergy and immunology Source Type: research