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Condition: Polyps

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Total 2492 results found since Jan 2013.

Biological sex as a modulator in rhinologic anatomy, physiology, and pathology: A scoping review
ConclusionsAlthough many sex-based differences exist in rhinology, further research is necessary to offer evidence-based treatment guidelines. Gonadal hormones should be studied as a therapeutic in rhinologic pathology as baseline physiologic differences exist such as those found in nasal mucosa receptor density.
Source: International Forum of Allergy and Rhinology - February 16, 2023 Category: Allergy & Immunology Authors: Shreya P. Ramkumar, Tripti Brar, Lisa Marks, Michael J. Marino, Devyani Lal Tags: REVIEW ARTICLE Source Type: research

Genetics and epigenetics of chronic rhinosinusitis
Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize outcomes through early diagnostics, personalized and novel therapeutics, and early prognostication. CRS associated with cystic fibrosis and primary ciliary dyskinesia has well-characterized genetic mutations. Most CRS subjects, however, do not exhibit identifiable monogenic alterations. Clustering in related individuals is seen in CRS with nasal polyps. Spouses of subjects with CRS without nasal polyps also may be at increased risk of the same disease.
Source: Journal of Allergy and Clinical Immunology - February 14, 2023 Category: Allergy & Immunology Authors: Devyani Lal, Tripti Brar, Shreya Pusapadi Ramkumar, Jingyun Li, Atsushi Kato, Luo Zhang Tags: Review article Source Type: research

Pheno-Endotyping Antrochoanal Nasal Polyposis
This article reviews the current knowledge of the etiology, inflammatory parameters, and microscopic findings of ACP.Recent FindingsThe inflammatory pattern of ACP appears to center around a neutrophilic inflammation T1-dominant endotype. Apart from the inflammatory component of ACP, at the microscopic level, the presence of tissue remodeling, mostly fibrin deposition and edema, and cysts in the epithelium and lamina propria has been described. Although the origin of this T1-dominant endotype immune response of ACPs is not entirely clear, it could be related to a lymphatic obstruction mechanism.SummaryThis review serves to...
Source: Current Allergy and Asthma Reports - February 11, 2023 Category: Allergy & Immunology Source Type: research

Doxycycline Improves Quality of Life and Anosmia in Chronic Rhinosinusitis With Nasal Polyposis: A Randomized Controlled Trial
CONCLUSION: Doxycycline improves the quality of life in patients with CRSwNP. It also has temporarily beneficial effects in improving the sense of smell. The levels of eosinophil in the blood and nasal secretions do not affect the response to treatment. Hence, doxycycline can be used in both eosinophilic and non-eosinophilic nasal polyps.This study was registered at Iranian Registry of Clinical Trials. https://www.irct.ir/ IRCTID: IRCT20210403050817N1.PMID:36740870 | DOI:10.1177/19458924231154066
Source: American Journal of Rhinology and Allergy - February 6, 2023 Category: ENT & OMF Authors: Mohammad Nabavi Saba Arshi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Sofia Sabouri Fatima Moosavian Javad Nazari Vahid Bakrani Fatemeh Atashrazm Source Type: research

Relationship between Eosinophilic and Neutrophilic Inflammation in Chinese Chronic Rhinosinusitis with Nasal Polyps
Conclusion: Tissue neutrophils might have a potential interaction and mutual promotion effect with eosinophils in CRSwNP. However, tissue neutrophilia would not pose significant risk for poor disease control after ESS. Further larger, prospective studies are needed to confirm our findings.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - February 6, 2023 Category: Allergy & Immunology Source Type: research

Analysis of Nasal Polyp Neutrophils by Single Cell RNA-Sequencing
In this study, we aimed to reveal the characteristics of NP neutrophils by single cell RNA-Sequencing (scRNA-Seq).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Naruhito Iwasaki, Julie Poposki, Aiko Klingler, James Norton, Lydia Suh, Whitney Stevens, Bruce Tan, Anju Peters, Leslie Grammer, Kevin Welch, Stephanie Smith, David Conley, Robert Kern, Robert Schleimer, Atsushi Kato Source Type: research