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Condition: Polyps

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Surgical management of rhinosinusitis for the allergist-immunologist
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease characterized by inflammation of the sinus, with or without nasal passage inflammation, occurring for more than 12 weeks at a time. CRS has historically been classified in 2 categories: CRS without nasal polyps or CRS with nasal polyps (25%-30% of cases). The mainstay of treatment for CRS with or without nasal polyps is medical management, and options may include a combination of saline irrigation, nasal steroids, allergy medications, antibiotics, oral steroids, and treatment with targeted monoclonal antibodies.
Source: Annals of Allergy, Asthma and Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Galit Almosnino, Ryan E Little Tags: Review Source Type: research

Distinct eicosanoid patterns in severe recalcitrant nasal polyposis
ConclusionElevated nasal LTE4, 12-month post-surgery, in NP recurrent subjects suggests that postoperative LTE4 measurements may indicate rapid NP regrowth. A distinct nasal eicosanoid profile may be used for the identification of the most severe recalcitrant patients in need of targeted immunomodulatory therapies.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - May 14, 2023 Category: Allergy & Immunology Authors: Axel Nordstr öm, Mattias Jangard, Marie Svedberg, Michael Ryott, Maria Kumlin Tags: ORIGINAL ARTICLE Source Type: research

The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.PMID:37160729 | DOI:10.1177/19458924231173205
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Jin-A Park Hyunkyung Cha Seung Koo Yang Hyun Tae Ryu Do Won Kim Seung-No Hong Min Suk Yang Dae Woo Kim Source Type: research

Histopathological Differences in Adult and Elderly Patients With Chronic Rhinosinusitis
CONCLUSION: Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.LEVEL OF EVIDENCE: 2.SHORT SUMMARY: Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.PMID:37160727 | DOI:10.1177/19458924231172078
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Hannah J Brown Ali M Baird Sarah Khalife Pedro Escobedo Peter Filip Peter Papagiannopoulos Paolo Gattuso Pete Batra Bobby A Tajudeen Source Type: research

The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.PMID:37160729 | DOI:10.1177/19458924231173205
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Jin-A Park Hyunkyung Cha Seung Koo Yang Hyun Tae Ryu Do Won Kim Seung-No Hong Min Suk Yang Dae Woo Kim Source Type: research

Histopathological Differences in Adult and Elderly Patients With Chronic Rhinosinusitis
CONCLUSION: Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.LEVEL OF EVIDENCE: 2.SHORT SUMMARY: Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.PMID:37160727 | DOI:10.1177/19458924231172078
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Hannah J Brown Ali M Baird Sarah Khalife Pedro Escobedo Peter Filip Peter Papagiannopoulos Paolo Gattuso Pete Batra Bobby A Tajudeen Source Type: research

The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.PMID:37160729 | DOI:10.1177/19458924231173205
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Jin-A Park Hyunkyung Cha Seung Koo Yang Hyun Tae Ryu Do Won Kim Seung-No Hong Min Suk Yang Dae Woo Kim Source Type: research

Histopathological Differences in Adult and Elderly Patients With Chronic Rhinosinusitis
CONCLUSION: Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.LEVEL OF EVIDENCE: 2.SHORT SUMMARY: Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.PMID:37160727 | DOI:10.1177/19458924231172078
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Hannah J Brown Ali M Baird Sarah Khalife Pedro Escobedo Peter Filip Peter Papagiannopoulos Paolo Gattuso Pete Batra Bobby A Tajudeen Source Type: research

The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.PMID:37160729 | DOI:10.1177/19458924231173205
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Jin-A Park Hyunkyung Cha Seung Koo Yang Hyun Tae Ryu Do Won Kim Seung-No Hong Min Suk Yang Dae Woo Kim Source Type: research

Histopathological Differences in Adult and Elderly Patients With Chronic Rhinosinusitis
CONCLUSION: Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.LEVEL OF EVIDENCE: 2.SHORT SUMMARY: Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.PMID:37160727 | DOI:10.1177/19458924231172078
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Hannah J Brown Ali M Baird Sarah Khalife Pedro Escobedo Peter Filip Peter Papagiannopoulos Paolo Gattuso Pete Batra Bobby A Tajudeen Source Type: research

Predictive Significance of Claudin-3 for Epithelial Barrier Dysfunction in Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: In this study, we suggest that claudin-3 could be a valuable biomarker for predicting nasal epithelial barrier defects and disease severity in CRSwNP.PMID:37153980
Source: Allergy, Asthma and Immunology Research - May 8, 2023 Category: Allergy & Immunology Authors: Zhi-Qun Huang Jing Ye Jing Liu Li-Ying Sun Hsiao Hui Ong Yong-Hao Wei Shu-Cai Fu Xiao-Xun Hu Yu Xu De-Yun Wang Source Type: research