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Total 2492 results found since Jan 2013.

Dupilumab Improves Outcomes in Patients with Chronic Rhinosinusitis with Nasal Polyps and Coexisting Asthma Irrespective of Baseline Asthma Characteristics
Source: Journal of Asthma and Allergy - April 18, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

Determinants of physician assessment of chronic rhinosinusitis disease control using EPOS 2020 criteria and the importance of incorporating patient perspectives of disease control
Conclusions: This study directly demonstrates the importance of patient-reported CRS control as a dominant influence on rhinologists ’ CRS control assessment. Knowledge of patient-reported CRS control may better align rhinologists’ CRS control assessments and treatment decisions with patients’ perspectives.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - April 13, 2023 Category: Allergy & Immunology Authors: Ahmad R. Sedaghat, David S. Caradonna, Rakesh K. Chandra, Christine Franzese, Stacey T. Gray, Ashleigh A. Halderman, Claire Hopkins, Edward C. Kuan, Jivianne T. Lee, Edward D. McCoul, Erin K. O'Brien, Steven D. Pletcher, Melissa A. Pynnonen, Tags: ORIGINAL ARTICLE Source Type: research

Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice
Allergic asthma is a chronic disease generally characterized by increased production of type 2 cytokines (eg, IL-4, IL-5, and IL-13) and accumulation of lymphocytes and eosinophils into the airway.1 Group 2 innate lymphoid cells (ILC2s) have been identified as critical upstream mediators of type 2 inflammation and the induced airway eosinophilia in translational models of allergic asthma.2-4 In humans, their numbers and activation state are increased in subgroups of people with asthma5-8 and chronic rhinosinusitis with nasal polyps.
Source: Journal of Allergy and Clinical Immunology - April 5, 2023 Category: Allergy & Immunology Authors: William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen Source Type: research

Use of patient-reported outcome measures and inflammatory biomarkers to differentiate chronic rhinosinusitis with nasal polyp endotypes: Is it feasible?
Ann Allergy Asthma Immunol. 2023 Apr;130(4):409-410. doi: 10.1016/j.anai.2023.01.004.NO ABSTRACTPMID:37005049 | DOI:10.1016/j.anai.2023.01.004
Source: Annals of Allergy, Asthma and Immunology - April 2, 2023 Category: Allergy & Immunology Authors: Jonathan A Bernstein Source Type: research

EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023
Rhinology. 2023 Mar 31. doi: 10.4193/Rhin22.489. Online ahead of print.ABSTRACTSevere chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a significant impact on the quality of life (QoL). It is typically characterized by a type 2 inflammatory reaction and by comorbidities such as asthma, allergies and NSAID-Exacerbated Respiratory Disease (N-ERD). Here, the European Forum for Research and Education in Allergy and Airway diseases discusses practical guidelines for patients on biologic treatment. Criteria for the selection of patients who would benefit from biologics were updated. Guidelines are...
Source: Rhinology - March 31, 2023 Category: ENT & OMF Authors: W J Fokkens A-S Viskens V Backer D Conti E De Corso P Gevaert G K Scadding M Wagemann M Bernal-Sprekelsen A Chaker E Heffler J K Han E Van Staeyen C Hopkins J Mullol A Peters S Reitsma B A Senior P W Hellings Source Type: research

Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SINUS-52 Studies
Source: Journal of Asthma and Allergy - March 31, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

Evaluation of the Clinical Features and Laboratory Data of Patients with Severe Eosinophilic Asthma Classified as Super-Responders, Partial Responders, or Nonresponders to Mepolizumab Treatment: A Real-Life Study
Conclusion: Baseline eosinophil count, eosinophil/lymphocyte ratio, and FEV1 (%) were found to be important predictors of response to mepolizumab treatment. Further studies are needed to define the characterization of mepolizumab responders in the real world.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - March 30, 2023 Category: Allergy & Immunology Source Type: research